ClinVar Miner

Variants studied for hereditary gastric cancer

Included ClinVar conditions (13):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
533 155 2119 1484 1142 20 4710

Gene and significance breakdown #

Total genes and gene combinations: 9
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
CDH1 455 138 1974 1323 747 18 3916
CTNNA1 54 10 4 147 389 0 603
APC 15 6 130 11 2 2 166
CDH1, LOC130059290 2 1 5 3 4 0 12
CDH1, LOC112486201, LOC128772402, LOC128772403, LOC128772404, LOC128772405, LOC128772406, LOC128772407, LOC128772408, LOC128772409, LOC128772410, LOC128772411, LOC128772412, LOC128772413, LOC128772414, LOC128822933, LOC128849170, LOC130059290, LOC130059291, LOC130059292, LOC130059293, LOC130059294, LOC130059295, LOC130059296, LOC130059297, LOC130059298 3 0 2 0 0 0 5
APC, LOC129994371 3 0 0 0 0 0 3
CDH1, CDH3 0 0 2 0 0 0 2
KRAS 1 0 1 0 0 0 2
CDH1, LOC128772407, LOC128849170 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 48
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 285 47 1732 1174 70 0 3308
Myriad Genetics, Inc. 270 83 86 424 1060 0 1923
European Reference Network on Genetic Tumour Risk Syndromes (ERN-GENTURIS), i3s - Instituto de Investigação e Inovação em Saúde, University of Porto 84 12 227 35 33 0 391
Fulgent Genetics, Fulgent Genetics 15 8 173 20 4 0 220
Counsyl 4 8 91 41 2 0 146
Illumina Laboratory Services, Illumina 0 0 46 23 41 0 110
Mendelics 3 2 26 19 15 0 65
KCCC/NGS Laboratory, Kuwait Cancer Control Center 1 0 6 0 28 0 35
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 18 3 3 0 24
OMIM 19 0 0 0 0 0 19
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 12 5 0 0 0 0 17
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 13 13
Department of Pathology and Laboratory Medicine, Sinai Health System 1 0 5 5 0 0 11
MGZ Medical Genetics Center 3 1 4 0 0 0 8
Pathway Genomics 4 0 2 1 1 0 8
Juno Genomics, Hangzhou Juno Genomics, Inc 5 3 0 0 0 0 8
Institute of Human Genetics, University of Leipzig Medical Center 2 0 3 1 0 0 6
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 2 3 0 0 0 0 5
GenomeConnect, ClinGen 0 0 0 0 0 5 5
GenomeConnect - No Stomach For Cancer 0 0 0 0 0 4 4
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 1 1 2 0 0 0 4
CSER _CC_NCGL, University of Washington 1 0 2 0 0 0 3
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 0 3 0 0 0 3
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 3 0 0 0 0 0 3
University of Washington Department of Laboratory Medicine, University of Washington 0 0 0 3 0 0 3
Genome-Nilou Lab 0 0 0 0 3 0 3
Department of Human Genetics, Hannover Medical School 0 0 3 0 0 0 3
King Laboratory, University of Washington 2 0 0 0 0 0 2
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 0 0 2 0 0 0 2
Laboratório de Genética Humana e Médica, Universidade Federal do Pará 1 0 0 0 0 1 2
Immunopatologia e Biomarcatori Oncologici/Bio-proteomics facility, Centro di Riferimento Oncologico 2 0 0 0 0 0 2
Pittsburgh Clinical Genomics Laboratory, University of Pittsburgh Medical Center 0 0 2 0 0 0 2
Baylor Genetics 0 0 1 0 0 0 1
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 0 1 0 0 0 1
Fundacion Rioja Salud, Center for Biomedical Research (CIBIR) 1 0 0 0 0 0 1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 1 0 0 0 0 1
Undiagnosed Diseases Network, NIH 0 1 0 0 0 0 1
Familial Cancer Clinical Unit, Spanish National Cancer Research Centre (CNIO) 1 0 0 0 0 0 1
GeneID Lab - Advanced Molecular Diagnostics 0 1 0 0 0 0 1
Cancer Variant Interpretation Group UK, Institute of Cancer Research, London 0 0 1 0 0 0 1
ClinGen CDH1 Variant Curation Expert Panel 0 0 0 0 1 0 1
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 0 0 1 0 0 0 1
Division of Medical Genetics, University of Washington 0 0 1 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 1 0 0 0 0 0 1
3billion, Medical Genetics 0 0 0 1 0 0 1
Human Genetics Bochum, Ruhr University Bochum 0 0 1 0 0 0 1
Institute of Immunology and Genetics Kaiserslautern 1 0 0 0 0 0 1
MVZ Medizinische Genetik Mainz 0 0 1 0 0 0 1

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