ClinVar Miner

Variants studied for benign neoplasm of adrenal gland

Included ClinVar conditions (23):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
297 103 1323 653 152 2 2495

Gene and significance breakdown #

Total genes and gene combinations: 35
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
SDHB 161 46 508 315 19 1 1040
SDHD 67 20 263 147 12 0 502
RET 12 3 203 78 53 0 346
TMEM127 7 19 93 15 26 0 152
LOC126861339, SDHD 17 3 43 34 2 0 98
MAX 0 1 37 9 19 0 63
LOC129929542, SDHB 6 0 27 26 0 0 59
KIF1B 0 0 37 4 6 0 47
VHL 3 2 27 2 0 0 34
LOC129934333, TMEM127 1 5 20 0 3 1 28
LOC107303340, VHL 4 4 15 4 0 0 27
SDHC 0 0 21 2 2 0 25
LOC129929541, SDHB 2 0 1 9 0 0 12
LOC106736614, RET 0 0 7 2 2 0 11
LOC130055850, MAX 0 0 5 1 5 0 11
SDHAF2 0 0 6 0 0 0 6
SDHA 1 0 2 2 0 0 5
ALG9, BTG4, C11orf52, CFAP68, CRYAB, DIXDC1, DLAT, FDXACB1, HOATZ, HSPB2, LAYN, MIR34B, MIR34BHG, MIR34C, NKAPD1, PIH1D2, POU2AF1, POU2AF3, PPP2R1B, SDHD, SIK2, TIMM8B 3 0 1 0 0 0 4
LOC129929541, LOC129929542, SDHB 2 0 2 0 0 0 4
ATP1A1 3 0 0 0 0 0 3
ATP2B3 3 0 0 0 0 0 3
KIF1B, LOC129388446 0 0 1 1 0 0 2
LOC100506321, MAX 1 0 1 0 0 0 2
MPZ, SDHC 0 0 0 0 2 0 2
ADRA2B, ASTL, DUSP2, GPAT2, STARD7, TMEM127 0 0 1 0 0 0 1
CFAP126, SDHC 0 0 0 0 1 0 1
CHURC1-FNTB, FNTB, LOC126861966, MAX 0 0 0 1 0 0 1
DDX46 0 0 1 0 0 0 1
KIF1B, LOC126805614 0 0 1 0 0 0 1
KIF1B, LOC129929363 0 0 0 1 0 0 1
LOC129929541, LOC129929542, LOC129929543, PADI2, SDHB 1 0 0 0 0 0 1
LOC129929542, LOC129929543, SDHB 1 0 0 0 0 0 1
MEN1 1 0 0 0 0 0 1
NF1 1 0 0 0 0 0 1
SDHD, TIMM8B 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 42
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 258 58 836 521 27 0 1699
Illumina Laboratory Services, Illumina 0 0 232 55 113 0 400
Fulgent Genetics, Fulgent Genetics 15 3 189 71 2 0 280
Baylor Genetics 6 1 57 0 0 0 64
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 20 1 0 0 21
Familial Cancer Clinic, Veneto Institute of Oncology 0 19 0 0 0 0 19
OMIM 15 0 0 0 0 0 15
Genome-Nilou Lab 0 0 0 0 15 0 15
Endocrinology Clinic, Seth G.S. Medical College 0 10 0 0 0 0 10
KCCC/NGS Laboratory, Kuwait Cancer Control Center 1 0 2 0 5 0 8
CSER _CC_NCGL, University of Washington 0 0 4 3 0 0 7
MGZ Medical Genetics Center 2 3 1 0 0 0 6
Institute of Human Genetics Munich, Klinikum Rechts Der Isar, TU München 6 0 0 0 0 0 6
deCODE genetics, Amgen 0 4 0 0 0 0 4
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 2 2 0 0 0 0 4
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 1 2 0 0 3
Mendelics 1 0 1 1 0 0 3
Institute of Human Genetics, University of Leipzig Medical Center 2 1 0 0 0 0 3
Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University 2 0 1 0 0 0 3
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 1 0 0 0 1 0 2
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 2 0 0 0 2
Cancer Variant Interpretation Group UK, Institute of Cancer Research, London 1 0 0 1 1 0 2
New York Genome Center 1 1 0 0 0 0 2
3billion 0 0 2 0 0 0 2
Division of Human Genetics, National Health Laboratory Service/University of the Witwatersrand 0 1 1 0 0 0 2
Genetic Services Laboratory, University of Chicago 1 0 0 0 0 0 1
Institute of Human Genetics, University of Goettingen 0 0 1 0 0 0 1
Institute of Human Genetics, Cologne University 0 0 1 0 0 0 1
Centogene AG - the Rare Disease Company 0 0 1 0 0 0 1
Clinical Genomics Laboratory, Washington University in St. Louis 0 1 0 0 0 0 1
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 0 0 1 0 0 0 1
Center of Genomic medicine, Geneva, University Hospital of Geneva 1 0 0 0 0 0 1
Department of Pediatrics, Memorial Sloan Kettering Cancer Center 1 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 1 1
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 1 0 0 1
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota 1 0 0 0 0 0 1
Department of Medicine, University of Texas Health Science Center at San Antonio 1 0 0 0 0 0 1
Division of Medical Genetics, University of Washington 1 0 0 0 0 0 1
Beijing Key Laboratry for Genetics of Birth Defects, Beijing Children's Hospital 1 0 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 1 1
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn 0 1 0 0 0 0 1
Neuberg Centre For Genomic Medicine, NCGM 1 0 0 0 0 0 1

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