If a variant has more than one submission, it may be counted in more than one significance column. If this is the
case, the total number of variants will be less than the sum of the other cells.
pathogenic |
likely pathogenic |
uncertain significance |
likely benign |
benign |
association |
risk factor |
not provided |
total |
257
|
125
|
2552
|
3224
|
208
|
4
|
1
|
12
|
6337
|
Gene and significance breakdown #
Total genes and gene combinations: 40
Gene or gene combination |
pathogenic |
likely pathogenic |
uncertain significance |
likely benign |
benign |
association |
risk factor |
not provided |
total |
RTEL1, RTEL1-TNFRSF6B
|
121
|
56
|
1000
|
1642
|
101
|
0 |
0 |
0 |
2902
|
TERT
|
75
|
33
|
1068
|
1183
|
49
|
1
|
0 |
7
|
2398
|
PARN
|
31
|
23
|
331
|
281
|
25
|
0 |
0 |
1
|
688
|
LOC110806263, TERT
|
9
|
1
|
85
|
99
|
3
|
0 |
0 |
4
|
199
|
SFTPC
|
0 |
1
|
8
|
12
|
13
|
0 |
0 |
0 |
33
|
RTEL1
|
9
|
5
|
5
|
0 |
0 |
0 |
0 |
0 |
19
|
ABCA3
|
0 |
3
|
12
|
0 |
0 |
0 |
0 |
0 |
15
|
MUC5B
|
0 |
0 |
8
|
4
|
2
|
0 |
1
|
0 |
15
|
SFTPA2
|
5
|
3
|
4
|
0 |
4
|
0 |
0 |
0 |
15
|
BMP1, SFTPC
|
0 |
0 |
0 |
1
|
8
|
0 |
0 |
0 |
9
|
BMP1, LOC129999976, SFTPC
|
0 |
0 |
1
|
1
|
2
|
0 |
0 |
0 |
4
|
NKX2-1, SFTA3
|
0 |
0 |
4
|
0 |
0 |
0 |
0 |
0 |
4
|
AHRR, BRD9, CEP72, EXOC3, NKD2, PDCD6, SDHA, SLC12A7, SLC6A18, SLC6A19, SLC9A3, TERT, TPPP, TRIP13, ZDHHC11, ZDHHC11B
|
2
|
0 |
1
|
0 |
0 |
0 |
0 |
0 |
3
|
LOC110806263, LOC110806264, LOC123493259, TERT
|
0 |
0 |
3
|
0 |
0 |
0 |
0 |
0 |
3
|
RTEL1, TNFRSF6B
|
1
|
0 |
2
|
0 |
0 |
0 |
0 |
0 |
3
|
LOC110806264, TERT
|
0 |
0 |
0 |
1
|
1
|
0 |
0 |
0 |
2
|
TOLLIP
|
0 |
0 |
2
|
0 |
0 |
1
|
0 |
0 |
2
|
BRD9, CEP72, CLPTM1L, IRX4, LPCAT1, MRPL36, NDUFS6, NKD2, SLC12A7, SLC6A18, SLC6A19, SLC6A3, SLC9A3, TERT, TPPP, TRIP13, ZDHHC11, ZDHHC11B
|
1
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1
|
CHRNA4, EEF1A2, FNDC11, GMEB2, HELZ2, KCNQ2, PPDPF, PTK6, RTEL1, SRMS, STMN3
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
CHRNA4, EEF1A2, FNDC11, GMEB2, HELZ2, KCNQ2, PPDPF, PTK6, RTEL1, SRMS, STMN3, TNFRSF6B
|
1
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1
|
CLPTM1L, SLC6A18, SLC6A19, SLC6A3, TERT
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
CLPTM1L, SLC6A3, TERT
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
CLPTM1L, TERT
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
CTC1
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
DSP
|
0 |
0 |
0 |
0 |
0 |
1
|
0 |
0 |
1
|
DTNBP1
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
EEF1A2, FNDC11, GMEB2, HELZ2, KCNQ2, PPDPF, PTK6, RTEL1, SRMS, STMN3
|
1
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1
|
FAM13A
|
0 |
0 |
1
|
0 |
0 |
1
|
0 |
0 |
1
|
HPS4
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
IL1RN
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
LAMA3
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
LOC110806306, TERC
|
1
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1
|
LOC128772425, LOC128772426, RTEL1, RTEL1-TNFRSF6B
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
MMP1
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
MMP19
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
NKD2, SLC12A7, SLC6A18, SLC6A19, TERT, TRIP13
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
NKX2-1
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
RTKN2
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
SFTPA1
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
SLC6A18, SLC6A19, TERT
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
Submitter and significance breakdown #
Submitter |
pathogenic |
likely pathogenic |
uncertain significance |
likely benign |
benign |
association |
risk factor |
not provided |
total |
Labcorp Genetics (formerly Invitae), Labcorp
|
230
|
102
|
2469
|
3204
|
167
|
0 |
0 |
0 |
6172
|
Fulgent Genetics, Fulgent Genetics
|
2
|
5
|
46
|
11
|
3
|
0 |
0 |
0 |
67
|
Illumina Laboratory Services, Illumina
|
0 |
0 |
8
|
15
|
23
|
0 |
0 |
0 |
46
|
Johns Hopkins Genomics, Johns Hopkins University
|
3
|
1
|
23
|
1
|
0 |
0 |
0 |
0 |
28
|
Genome-Nilou Lab
|
0 |
0 |
0 |
2
|
26
|
0 |
0 |
0 |
28
|
Alder lab, University of Pittsburgh
|
1
|
3
|
20
|
0 |
0 |
0 |
0 |
0 |
24
|
OMIM
|
17
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17
|
GeneReviews
|
3
|
0 |
0 |
0 |
0 |
0 |
0 |
10
|
13
|
Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
|
2
|
2
|
8
|
0 |
0 |
0 |
0 |
0 |
12
|
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago
|
0 |
2
|
9
|
0 |
0 |
0 |
0 |
0 |
11
|
Mendelics
|
0 |
1
|
4
|
2
|
2
|
0 |
0 |
0 |
9
|
University of Washington Center for Mendelian Genomics, University of Washington
|
9
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
9
|
Baylor Genetics
|
0 |
1
|
6
|
0 |
0 |
0 |
0 |
0 |
7
|
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute
|
4
|
0 |
2
|
0 |
0 |
0 |
0 |
0 |
6
|
HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas
|
0 |
0 |
3
|
0 |
0 |
4
|
0 |
0 |
5
|
Godley laboratory, The University of Chicago
|
2
|
2
|
1
|
0 |
0 |
0 |
0 |
0 |
5
|
Molecular Diagnostics Laboratory, M Health Fairview: University of Minnesota
|
0 |
3
|
0 |
0 |
0 |
0 |
0 |
0 |
3
|
Neuberg Centre For Genomic Medicine, NCGM
|
0 |
0 |
3
|
0 |
0 |
0 |
0 |
0 |
3
|
Genetics and Molecular Pathology, SA Pathology
|
0 |
0 |
2
|
0 |
0 |
0 |
0 |
0 |
2
|
GenomeConnect - Invitae Patient Insights Network
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2
|
2
|
Dept. of Cytogenetics, ICMR- National Institute of Immunohaematology
|
0 |
0 |
2
|
0 |
0 |
0 |
0 |
0 |
2
|
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine
|
0 |
0 |
0 |
0 |
0 |
0 |
1
|
0 |
1
|
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
Institute for Human Genetics and Genomic Medicine, Uniklinik RWTH Aachen
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
Undiagnosed Diseases Network, NIH
|
0 |
1
|
0 |
0 |
0 |
0 |
0 |
0 |
1
|
Juno Genomics, Hangzhou Juno Genomics, Inc
|
0 |
1
|
0 |
0 |
0 |
0 |
0 |
0 |
1
|
Genomic Medicine Lab, University of California San Francisco
|
0 |
1
|
0 |
0 |
0 |
0 |
0 |
0 |
1
|
The Laboratory of Genetics and Metabolism, Hunan Children’s Hospital
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
Department of Medical Genomics, Royal Prince Alfred Hospital
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
Pittsburgh Clinical Genomics Laboratory, University of Pittsburgh Medical Center
|
0 |
0 |
1
|
0 |
0 |
0 |
0 |
0 |
1
|
New York Genome Center
|
1
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1
|
Dept. Genetics and Cancer, Menzies Institute for Medical Research, University of Tasmania
|
0 |
1
|
0 |
0 |
0 |
0 |
0 |
0 |
1
|
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