ClinVar Miner

Variants studied for adrenal gland cancer

Included ClinVar conditions (16):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
143 124 648 244 36 3 1157

Gene and significance breakdown #

Total genes and gene combinations: 16
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
SDHA 25 16 358 157 19 0 565
SDHB 56 22 160 40 7 1 279
RET 54 19 123 46 10 2 231
TP53 5 40 4 0 0 0 48
CTNNB1 0 11 0 0 0 0 11
NRAS 0 5 0 0 0 0 5
PIK3CA 0 4 0 0 0 0 4
BRAF 0 3 0 0 0 0 3
GNAS 0 3 0 0 0 0 3
PADI2, SDHB 2 0 0 0 0 0 2
CHEK2 0 0 1 0 0 0 1
H3F3A 0 1 0 0 0 0 1
LOC106736614, RET 0 0 1 0 0 0 1
LOC110121502, MCS+9.7, RET 0 0 0 1 0 0 1
SDHAF2 1 0 0 0 0 0 1
ZMYND11 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 27
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 72 31 501 187 26 0 817
Counsyl 9 9 134 58 8 0 218
Database of Curated Mutations (DoCM) 0 79 0 0 0 0 79
Fulgent Genetics 13 2 40 0 0 0 55
Mendelics 1 0 43 2 2 0 48
OMIM 37 0 0 0 0 0 37
ARUP Institute,ARUP Laboratories 31 0 0 0 0 0 31
Center for Human Genetics, Inc 11 1 3 0 0 0 15
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 9 0 0 0 0 0 9
Equipe Genetique des Anomalies du Developpement,Université de Bourgogne 0 0 5 0 2 0 7
Human Genome Sequencing Center Clinical Lab,Baylor College of Medicine 5 1 0 0 0 0 6
Integrated Genetics/Laboratory Corporation of America 2 0 2 0 1 0 5
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 4 0 0 0 0 0 4
GeneReviews 4 0 0 0 0 0 4
Department of Pediatrics,Memorial Sloan Kettering Cancer Center 3 0 0 0 0 0 3
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 1 0 0 0 1 0 2
GenomeConnect, ClinGen 0 0 0 0 0 2 2
Genetic Services Laboratory, University of Chicago 0 1 0 0 0 0 1
ClinVar Staff, National Center for Biotechnology Information (NCBI) 0 0 0 0 0 1 1
UCLA Clinical Genomics Center, UCLA 1 0 0 0 0 0 1
CSER_CC_NCGL; University of Washington Medical Center 0 0 1 0 0 0 1
HudsonAlpha Institute for Biotechnology 1 0 0 0 0 0 1
Foundation for Research in Genetics and Endocrinology,Institute of Human Genetics 0 1 0 0 0 0 1
Donald Williams Parsons Laboratory,Baylor College of Medicine 0 1 0 0 0 0 1
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 1 0 0 0 1
Geisinger Autism and Developmental Medicine Institute,Geisinger Health System 1 0 0 0 0 0 1
Department of Genetics,Sultan Qaboos University Hospital, Oman 0 0 1 0 0 0 1

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