ClinVar Miner

Variants studied for B-cell neoplasm

Included ClinVar conditions (16):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
46 258 15 0 0 1 316

Gene and significance breakdown #

Total genes and gene combinations: 85
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Gene or gene combination pathogenic likely pathogenic uncertain significance not provided total
TP53 6 90 0 0 94
BRAF 0 25 0 0 25
LIG4 2 0 12 0 14
NRAS 0 14 0 0 14
HRAS, LRRC56 0 13 0 0 13
BCL10 9 0 1 0 10
FBXW7 0 10 0 0 10
PTPN11 0 7 0 0 7
SF3B1 0 6 0 0 6
B2M 0 5 0 0 5
IDH1 0 5 0 0 5
KRAS 1 4 0 0 5
CDK4 0 4 0 0 4
MYC 4 0 0 0 4
ATM 2 1 0 0 3
FGFR3 3 1 0 0 3
IDH2 0 3 0 0 3
JAK3 0 3 0 0 3
NF1 0 2 1 0 3
PIK3CA 0 3 0 0 3
PLCG2 0 3 0 0 3
PTEN 3 0 0 0 3
XPO1 0 3 0 0 3
ATM, C11orf65 2 0 0 0 2
BRCA2 1 1 0 0 2
BTK 1 0 0 1 2
CREBBP 1 1 0 0 2
DNMT3A 1 1 0 0 2
FAT1 0 2 0 0 2
KMT2C 0 2 0 0 2
PMS2 2 0 0 0 2
SF3B2 0 2 0 0 2
TBL1XR1 0 2 0 0 2
TET2 0 2 0 0 2
ARID4A 0 1 0 0 1
AURKA 0 1 0 0 1
BAP1 0 1 0 0 1
BARD1 0 1 0 0 1
BCORL1 0 1 0 0 1
BRCA1 0 0 1 0 1
CD79B, GH-LCR 0 1 0 0 1
CDKN2C 0 1 0 0 1
CHEK2 0 1 0 0 1
CRBN, TRNT1 0 1 0 0 1
CYLD 0 1 0 0 1
DIS3 0 1 0 0 1
EIF1AX 0 1 0 0 1
ERCC4 1 0 0 0 1
ERF 0 1 0 0 1
ETV6 0 1 0 0 1
FLT3 0 1 0 0 1
FOXO1 1 0 0 0 1
H1-4 0 1 0 0 1
H2AC16 0 1 0 0 1
H2AC17 0 1 0 0 1
H3C1 0 1 0 0 1
HDAC4 0 1 0 0 1
IL7R 0 1 0 0 1
JAK2, ZBTB20 0 1 0 0 1
KDM5C, LOC130068308 0 1 0 0 1
KMT2D 0 1 0 0 1
LATS1 0 1 0 0 1
LOC107982234, WT1 0 1 0 0 1
LOC130063979, PIK3R2 0 1 0 0 1
MGA 0 1 0 0 1
MST1R 0 1 0 0 1
MYD88 1 1 0 0 1
NBN 1 0 0 0 1
NCOR2 0 1 0 0 1
NKX2-1, SFTA3 0 1 0 0 1
P2RY8 0 1 0 0 1
PALB2 1 0 0 0 1
PIK3R2 0 1 0 0 1
RECQL4 0 1 0 0 1
RXRA 0 1 0 0 1
SAMHD1 0 1 0 0 1
SF3A1 1 0 0 0 1
SGK1 0 1 0 0 1
SH2B3 0 1 0 0 1
SOCS1 1 0 0 0 1
STAT3 1 0 0 0 1
TCF3 0 1 0 0 1
TET3 0 1 0 0 1
TRAF5 0 1 0 0 1
YAP1 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 13
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Submitter pathogenic likely pathogenic uncertain significance not provided total
Database of Curated Mutations (DoCM) 0 198 0 1 199
Xiao lab, Department of Pathology, Memorial Sloan Kettering Cancer Center 1 52 0 0 53
OMIM 21 0 0 0 21
Department Of Pathology & Laboratory Medicine, University Of Pennsylvania 12 2 0 0 14
Fulgent Genetics, Fulgent Genetics 2 0 9 0 11
Wasik Lab, Fox Chase Cancer Center 3 5 1 0 9
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 1 0 4 0 5
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 3 2 0 0 5
University Health Network, Princess Margaret Cancer Centre 3 0 0 0 3
Biotechnology, Institute of Science, Nirma University 1 1 0 0 2
Baylor Genetics 0 0 1 0 1
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital 0 1 0 0 1
Pele Pequeno Principe Research Institute, Faculdades Pequeno Principe 0 0 1 0 1

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