Variants studied for lymphoid neoplasm

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	association	risk factor	not provided	total
98	340	110	17	32	2	3	5	590

Gene and significance breakdown #

Total genes and gene combinations: 121

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Gene or gene combination	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	association	risk factor	not provided	total
TP53	8	99	0	0	0	0	0	0	105
NBN	8	11	39	10	20	0	0	2	85
PRF1	2	2	13	1	9	0	0	0	27
BRAF	3	25	0	0	0	0	0	0	25
IKZF1	1	6	10	0	0	2	0	0	19
PAX5	1	13	2	0	0	0	0	0	15
LIG4	2	0	12	0	0	0	0	0	14
NRAS	0	14	0	0	0	0	0	0	14
HRAS, LRRC56	0	13	0	0	0	0	0	0	13
BCL10	11	0	1	0	0	0	0	0	12
FBXW7	0	10	0	0	0	0	0	0	10
PTPN11	2	7	0	0	0	0	0	0	9
MYC	4	3	1	0	0	0	0	0	8
EZH2	0	7	0	0	0	0	0	0	7
B2M	1	5	0	0	0	0	0	0	6
CASP10	3	0	3	0	0	0	0	0	6
GNB1	2	2	0	2	0	0	0	0	6
HAVCR2	1	1	3	0	1	0	3	0	6
IDH1	0	5	1	0	0	0	0	0	6
KRAS	1	4	1	0	0	0	0	0	6
PIK3CA	0	6	0	0	0	0	0	0	6
RHOA	0	6	0	0	0	0	0	0	6
SF3B1	0	6	0	0	0	0	0	0	6
ATM	4	1	0	0	0	0	0	0	5
ERG	0	0	5	0	0	0	0	0	5
INSL6, JAK2	4	0	0	0	0	0	0	1	5
JAK3	0	5	0	0	0	0	0	0	5
TET2	0	2	3	0	0	0	0	0	5
ATM, C11orf65	4	0	0	0	0	0	0	0	4
BCR	0	0	3	1	0	0	0	0	4
CDK4	0	4	0	0	0	0	0	0	4
CDKN2A	0	2	2	0	0	0	0	0	4
FGFR3	3	1	1	0	0	0	0	0	4
FLT3	3	1	0	0	0	0	0	0	4
RAD54L	1	1	1	1	0	0	0	0	4
ABL1	1	2	0	0	0	0	0	0	3
DNMT3A	2	1	0	0	0	0	0	0	3
IDH2	0	3	0	0	0	0	0	0	3
JAK1, LOC126805749	0	3	0	0	0	0	0	0	3
KMT2D	0	3	0	0	0	0	0	0	3
LOC126860438, NBN	1	0	0	1	2	0	0	0	3
NF1	0	2	1	0	0	0	0	0	3
PLCG2	0	3	0	0	0	0	0	0	3
PTEN	3	0	0	0	0	0	0	0	3
XPO1	0	3	0	0	0	0	0	0	3
BAX	2	0	0	0	0	0	0	0	2
BRCA2	1	1	0	0	0	0	0	0	2
BTK	1	0	0	0	0	0	0	1	2
CREBBP	1	1	0	0	0	0	0	0	2
ETV6	1	1	0	0	0	0	0	0	2
FAT1	0	2	0	0	0	0	0	0	2
FGFR1	0	2	0	0	0	0	0	0	2
IL7R	0	2	0	0	0	0	0	0	2
KMT2C	0	2	0	0	0	0	0	0	2
LOC105376032, PAX5	0	1	1	0	0	0	0	0	2
MAP2K1	0	2	0	0	0	0	0	0	2
PMS2	2	0	0	0	0	0	0	0	2
SF3B2	0	2	0	0	0	0	0	0	2
TBL1XR1	0	2	0	0	0	0	0	0	2
ARID4A	0	1	0	0	0	0	0	0	1
AURKA	0	1	0	0	0	0	0	0	1
BAP1	0	1	0	0	0	0	0	0	1
BARD1	0	1	0	0	0	0	0	0	1
BCORL1	0	1	0	0	0	0	0	0	1
BRCA1	0	0	1	0	0	0	0	0	1
CBL	0	0	1	0	0	0	0	0	1
CD79B, GH-LCR	0	1	0	0	0	0	0	0	1
CDKN2B, LOC130001608	0	0	1	0	0	0	0	0	1
CDKN2C	0	1	0	0	0	0	0	0	1
CHEK2	0	1	0	0	0	0	0	0	1
CRBN, TRNT1	0	1	0	0	0	0	0	0	1
CRLF2	1	0	0	0	0	0	0	0	1
CSF3R	1	0	0	0	0	0	0	0	1
CYLD	0	1	0	0	0	0	0	0	1
DIS3	0	1	0	0	0	0	0	0	1
EIF1AX	0	1	0	0	0	0	0	0	1
ERCC4	1	0	0	0	0	0	0	0	1
ERF	0	1	0	0	0	0	0	0	1
ETV6, LOC126861452	1	0	0	0	0	0	0	0	1
FGFR4	0	0	0	1	0	0	0	0	1
FOXO1	1	0	0	0	0	0	0	0	1
H1-4	0	1	0	0	0	0	0	0	1
H2AC16	0	1	0	0	0	0	0	0	1
H2AC17	0	1	0	0	0	0	0	0	1
H3C1	0	1	0	0	0	0	0	0	1
HDAC4	0	1	0	0	0	0	0	0	1
JAK2, ZBTB20	0	1	0	0	0	0	0	0	1
KDM5C, LOC130068308	0	1	0	0	0	0	0	0	1
KIT	1	0	0	0	0	0	0	0	1
KLHDC8B	1	0	0	0	0	0	0	0	1
LATS1	0	1	0	0	0	0	0	0	1
LOC107982234, WT1	0	1	0	0	0	0	0	0	1
LOC130063979, PIK3R2	0	1	0	0	0	0	0	0	1
LRRC41, RAD54L	0	0	1	0	0	0	0	0	1
MET	0	0	1	0	0	0	0	0	1
MGA	0	1	0	0	0	0	0	0	1
MST1R	0	1	0	0	0	0	0	0	1
MYD88	1	1	0	0	0	0	0	0	1
NCOR2	0	1	0	0	0	0	0	0	1
NKX2-1, SFTA3	0	1	0	0	0	0	0	0	1
NOTCH1	1	0	0	0	0	0	0	0	1
NSD2	0	0	1	0	0	0	0	0	1
NT5C2	0	0	0	0	0	0	0	1	1
P2RY8	0	1	0	0	0	0	0	0	1
PALB2	1	0	0	0	0	0	0	0	1
PIK3R2	0	1	0	0	0	0	0	0	1
RAD54B	1	0	0	0	0	0	0	0	1
RECQL4	0	1	0	0	0	0	0	0	1
RXRA	0	1	0	0	0	0	0	0	1
SAMHD1	0	1	0	0	0	0	0	0	1
SDHA	0	0	1	0	0	0	0	0	1
SETBP1	0	1	0	0	0	0	0	0	1
SF3A1	1	0	0	0	0	0	0	0	1
SGK1	0	1	0	0	0	0	0	0	1
SH2B3	0	1	0	0	0	0	0	0	1
SOCS1	1	0	0	0	0	0	0	0	1
STAT3	1	0	0	0	0	0	0	0	1
TCF3	0	1	0	0	0	0	0	0	1
TET3	0	1	0	0	0	0	0	0	1
TRAF5	0	1	0	0	0	0	0	0	1
YAP1	0	1	0	0	0	0	0	0	1

Submitter and significance breakdown #

Total submitters: 37

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Submitter	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	association	risk factor	not provided	total
Database of Curated Mutations (DoCM)	5	238	0	0	0	0	0	3	246
Fulgent Genetics, Fulgent Genetics	12	8	56	10	2	0	0	0	88
Xiao lab, Department of Pathology, Memorial Sloan Kettering Cancer Center	1	55	2	0	0	0	0	0	58
OMIM	45	0	0	0	0	0	3	0	48
Genomic Diagnostics Laboratory, National Institute of Medical Genomics	1	22	12	0	0	0	0	0	35
KCCC/NGS Laboratory, Kuwait Cancer Control Center	0	0	0	4	31	0	0	0	35
St. Jude Molecular Pathology, St. Jude Children's Research Hospital	5	2	10	0	0	0	0	0	17
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago	1	1	13	1	0	0	0	0	16
Department Of Pathology & Laboratory Medicine, University Of Pennsylvania	12	2	0	0	0	0	0	0	14
Wasik Lab, Fox Chase Cancer Center	3	5	1	0	0	0	0	0	9
Mendelics	3	0	2	1	0	0	0	0	6
Pathology Department, Puerta del Mar University Hospital	0	0	4	1	0	0	0	0	5
Center for Advanced Molecular Diagnostics, Cytogenetics Laboratory, Brigham and Women's Hospital	4	0	0	0	0	0	0	0	4
University Health Network, Princess Margaret Cancer Centre	4	0	0	0	0	0	0	0	4
Molecular Diagnostics Laboratory, University of Rochester Medical Center	0	0	3	0	0	0	0	0	3
Baylor Genetics	0	1	1	0	0	0	0	0	2
Revvity Omics, Revvity	0	0	2	0	0	0	0	0	2
Diagnostic Molecular Genetics Laboratory, Memorial Sloan Kettering Cancer Center	2	0	0	0	0	0	0	0	2
Juno Genomics, Hangzhou Juno Genomics, Inc	0	2	0	0	0	0	0	0	2
Laboratorios de Investigación en Biología Molecular e Inmunología, Universidad Autónoma de Nayarit	0	0	0	0	0	2	0	0	2
Biotechnology, Institute of Science, Nirma University	1	1	0	0	0	0	0	0	2
Genetic Services Laboratory, University of Chicago	0	1	0	0	0	0	0	0	1
Institute for Genomic Medicine (IGM) Clinical Laboratory, Nationwide Children's Hospital	0	1	0	0	0	0	0	0	1
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center	0	1	0	0	0	0	0	0	1
Genomic Research Center, Shahid Beheshti University of Medical Sciences	0	0	1	0	0	0	0	0	1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center	0	0	1	0	0	0	0	0	1
Centre for Mendelian Genomics, University Medical Centre Ljubljana	0	0	1	0	0	0	0	0	1
Institute of Human Genetics, University of Leipzig Medical Center	0	1	0	0	0	0	0	0	1
Department of Pathology and Laboratory Medicine, Sinai Health System	0	0	1	0	0	0	0	0	1
GenomeConnect, ClinGen	0	0	0	0	0	0	0	1	1
Pele Pequeno Principe Research Institute, Faculdades Pequeno Principe	0	0	1	0	0	0	0	0	1
Mayo Clinic Genomics Laboratory, Mayo Clinic	1	0	0	0	0	0	0	0	1
Genome-Nilou Lab	0	0	0	0	1	0	0	0	1
Molecular Genetics Lab, CHRU Brest	0	1	0	0	0	0	0	0	1
3billion	0	0	1	0	0	0	0	0	1
GenomeConnect - Invitae Patient Insights Network	0	0	0	0	0	0	0	1	1
Solve-RD Consortium	0	1	0	0	0	0	0	0	1

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