ClinVar Miner

Variants studied for ventricular tachycardia

Included ClinVar conditions (38):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
215 234 4600 3873 355 27 8716

Gene and significance breakdown #

Total genes and gene combinations: 62
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
RYR2 97 132 3519 2792 223 11 6316
TRDN 35 37 453 480 52 1 1031
CASQ2 52 38 232 274 33 4 589
LOC126806068, RYR2 12 12 209 132 8 1 343
LOC126806067, RYR2 0 0 101 77 6 0 166
CALM1 3 2 15 52 7 2 77
CALM1, LOC126862021 5 1 3 19 0 0 28
CASQ2, VANGL1 0 0 0 21 8 0 24
TTN 0 0 5 5 7 0 17
TECRL 6 5 4 0 0 0 14
CALM3 4 0 2 0 4 0 10
SCN5A 0 1 3 2 0 2 8
DSP 0 1 5 0 1 0 7
ACTN2, MT1HL1, MTR, RYR2 0 0 6 0 0 0 6
ANK2 0 1 2 1 0 2 6
PKP2 1 1 2 1 0 0 5
CACNA1C 0 0 4 0 0 0 4
CALM1, LOC130056272 0 0 0 4 0 0 4
KCNH2 0 0 3 0 1 0 4
AKAP9 0 0 1 2 0 0 3
HCN4 0 0 2 0 1 0 3
KCNJ2 0 0 0 0 0 3 3
MYBPC3 0 0 3 0 0 0 3
CACNB2 0 0 0 1 1 0 2
KCNQ1 0 0 1 0 0 1 2
LAMA4 0 0 1 1 0 0 2
LOC126806066, RYR2 0 0 2 0 0 0 2
MYLK2 0 0 1 1 0 0 2
TRPM4 0 0 1 1 0 0 2
ABCC9 0 0 0 0 1 0 1
ATP1A1, CASQ2, LINC01649, MAB21L3, NHLH2, SLC22A15 0 0 1 0 0 0 1
CALM1, LOC112272566 0 0 0 0 1 0 1
DMPK 0 0 1 0 0 0 1
DPP6 0 0 1 0 0 0 1
DSG2 0 0 1 0 0 0 1
DTNA 0 0 1 0 0 0 1
EYA4 0 0 0 1 0 0 1
FKTN 0 0 0 1 0 0 1
FPGT-TNNI3K, TNNI3K 0 1 0 0 0 0 1
HCN4, LOC105370890 0 0 1 0 0 0 1
KLHL8 0 0 1 0 0 0 1
LDB3 0 0 0 1 0 0 1
LMNA 0 0 1 0 0 0 1
LOC101927055, TTN 0 0 1 0 0 0 1
LOC126806067, LOC126806068, MIR4428, RYR2 0 0 1 0 0 0 1
LOC126806067, LOC126806068, RYR2 0 0 1 0 0 0 1
LOC126806422, TTN 0 0 0 0 1 0 1
LOC126806424, TTN 0 0 0 1 0 0 1
LOC126861897, MHRT, MYH7 0 0 1 0 0 0 1
LOC126861898, MYH7 0 1 0 0 0 0 1
LOC129389631, LOC129389632, LOC129389633, TRDN 0 0 1 0 0 0 1
LOC129389631, TRDN 0 0 1 0 0 0 1
MYH6 0 0 0 1 0 0 1
PRKAG2 0 0 1 0 0 0 1
PTPN11 0 1 0 0 0 0 1
RAF1 0 0 1 0 0 0 1
RBM20 0 0 1 0 0 0 1
SCN4B 0 0 1 0 0 0 1
SNTA1 0 0 0 1 0 0 1
SOS1 0 0 1 0 0 0 1
TCAP 0 0 1 0 0 0 1
VCL 0 0 0 1 0 0 1

Submitter and significance breakdown #

Total submitters: 83
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 178 109 3239 3478 276 0 7280
All of Us Research Program, National Institutes of Health 1 0 1725 897 87 0 2710
Illumina Laboratory Services, Illumina 0 0 297 129 104 0 421
Fulgent Genetics, Fulgent Genetics 7 25 281 29 3 0 345
Genome-Nilou Lab 1 16 87 35 58 0 197
Victorian Clinical Genetics Services, Murdoch Childrens Research Institute 17 11 22 2 0 0 52
Center for Advanced Laboratory Medicine, UC San Diego Health, University of California San Diego 1 2 16 21 12 0 52
Blueprint Genetics 1 13 28 1 0 0 43
Center For Human Genetics And Laboratory Diagnostics, Dr. Klein, Dr. Rost And Colleagues 4 15 18 0 0 0 37
OMIM 28 0 0 0 0 0 28
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 0 0 9 6 13 0 28
Baylor Genetics 3 5 14 0 0 0 22
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 19 0 0 0 19
Revvity Omics, Revvity 1 8 7 0 0 0 16
Genome Diagnostics Laboratory, University Medical Center Utrecht 0 0 1 2 10 0 13
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine 2 10 0 0 0 0 12
Centre for Mendelian Genomics, University Medical Centre Ljubljana 1 2 9 0 0 0 12
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center 0 0 0 0 11 0 11
MGZ Medical Genetics Center 1 0 9 0 0 0 10
GeneReviews 0 0 0 0 0 10 10
New York Genome Center 0 0 10 0 0 0 10
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 0 0 5 1 3 0 9
Biesecker Lab/Clinical Genomics Section, National Institutes of Health 0 0 5 2 1 0 8
Mendelics 0 1 2 1 4 0 8
Cardiovascular Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust 0 0 0 0 0 8 8
Institute of Human Genetics, University of Leipzig Medical Center 1 4 2 1 0 0 8
Juno Genomics, Hangzhou Juno Genomics, Inc 0 5 3 0 0 0 8
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 2 5 0 0 0 0 7
Neuberg Centre For Genomic Medicine, NCGM 1 1 5 0 0 0 7
Cohesion Phenomics 0 0 0 7 0 0 7
Lildballe Lab, Aarhus University Hospital 0 5 2 0 0 0 7
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 0 0 6 0 0 0 6
Agnes Ginges Centre for Molecular Cardiology, Centenary Institute 1 2 2 0 1 0 6
MVZ Medizinische Genetik Mainz 0 0 6 0 0 0 6
CSER _CC_NCGL, University of Washington 0 0 4 1 0 0 5
Molecular Diagnostic Laboratory for Inherited Cardiovascular Disease, Montreal Heart Institute 0 0 5 0 0 0 5
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 5 5
Center for Medical Genetics Ghent, University of Ghent 1 3 0 0 0 0 4
Division of Human Genetics, Children's Hospital of Philadelphia 0 0 4 0 0 0 4
Center for Human Genetics, University of Leuven 0 3 1 0 0 0 4
GenomeConnect, ClinGen 0 0 0 0 0 4 4
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen 0 0 0 0 4 0 4
Molecular Genetics Laboratory, Motol Hospital 0 4 0 0 0 0 4
Molecular Genetics, Royal Melbourne Hospital 1 0 3 0 0 0 4
KardioGenetik, Herz- und Diabeteszentrum NRW 1 1 2 0 0 0 4
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 0 3 0 0 0 3
Genetics and Genomics Program, Sidra Medicine 1 0 2 0 0 0 3
Clinical Genomics Laboratory, Stanford Medicine 0 0 3 0 0 0 3
Institute of Immunology and Genetics Kaiserslautern 1 0 2 0 0 0 3
Intergen, Intergen Genetics and Rare Diseases Diagnosis Center 0 0 2 0 0 0 2
Nyegaard lab; Aarhus University 2 0 0 0 0 0 2
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 1 1 0 0 0 2
Petrovsky National Research Centre of Surgery, The Federal Agency for Scientific Organizations 0 0 2 0 0 0 2
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 0 1 1 0 0 0 2
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 0 2 0 0 0 0 2
Phosphorus, Inc. 0 0 2 0 0 0 2
SIB Swiss Institute of Bioinformatics 0 2 0 0 0 0 2
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 0 0 2 0 0 0 2
Pittsburgh Clinical Genomics Laboratory, University of Pittsburgh Medical Center 0 0 2 0 0 0 2
Clinical Genetics Laboratory, University Hospital Schleswig-Holstein 2 0 0 0 0 0 2
Institute of Human Genetics, University of Goettingen 0 0 1 0 0 0 1
Mayo Clinic Laboratories, Mayo Clinic 0 0 1 0 0 0 1
Strand Center for Genomics and Personalized Medicine, Strand Life Sciences Pvt Ltd 0 1 0 0 0 0 1
Genomic Medicine Center of Excellence, King Faisal Specialist Hospital and Research Centre 1 0 0 0 0 0 1
Genomic Research Center, Shahid Beheshti University of Medical Sciences 1 0 0 0 0 0 1
Stanford Center for Inherited Cardiovascular Disease, Stanford University 0 1 0 0 0 0 1
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 0 0 1 0 0 0 1
Center of Genomic medicine, Geneva, University Hospital of Geneva 1 0 0 0 0 0 1
Institute for Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin 1 0 0 0 0 0 1
Institute Of Molecular Biology And Genetics, Federal Almazov National Medical Research Centre 1 0 0 0 0 0 1
Royal Brompton Clinical Genetics And Genomics Laboratory, NHS South East Genomic Laboratory Hub 0 1 0 0 0 0 1
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City 1 0 0 0 0 0 1
Johns Hopkins Genomics, Johns Hopkins University 0 1 0 0 0 0 1
Medical Genetics Laboratory, West China Hospital, Sichuan University 0 0 1 0 0 0 1
Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences 0 1 0 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 0 1 0 0 0 0 1
3billion, Medical Genetics 0 1 0 0 0 0 1
Clinical Center for Gene Diagnosis and Therapy, Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University 0 1 0 0 0 0 1
Suma Genomics 0 0 1 0 0 0 1
Genomics England Pilot Project, Genomics England 0 1 0 0 0 0 1
Molecular and Cytogenetics Laboratory, Americain University of Beirut Medical Center 0 1 0 0 0 0 1
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 0 1 0 0 0 1
Razi Pathobiology & Medical Genetics 0 0 0 0 1 0 1

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