If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.
pathogenic | likely pathogenic | uncertain significance | likely benign | benign | not provided | total |
---|---|---|---|---|---|---|
11 | 10 | 15 | 10 | 2 | 4 | 49 |
Gene and significance breakdown #
Gene or gene combination | pathogenic | likely pathogenic | uncertain significance | likely benign | benign | not provided | total |
---|---|---|---|---|---|---|---|
NSDHL | 10 | 5 | 9 | 10 | 2 | 4 | 37 |
CTNNB1, LOC126806658 | 0 | 4 | 0 | 0 | 0 | 0 | 4 |
TSC1 | 0 | 0 | 2 | 0 | 0 | 0 | 2 |
APC | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
ERCC2 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
LOC130002133, PTCH1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
NF1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
PTCH1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
SUFU | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Submitter and significance breakdown #
Submitter | pathogenic | likely pathogenic | uncertain significance | likely benign | benign | not provided | total |
---|---|---|---|---|---|---|---|
Fulgent Genetics, Fulgent Genetics | 0 | 0 | 6 | 9 | 0 | 0 | 15 |
St. Jude Molecular Pathology, St. Jude Children's Research Hospital | 1 | 1 | 6 | 0 | 0 | 0 | 8 |
Genetic Services Laboratory, University of Chicago | 4 | 3 | 0 | 0 | 0 | 0 | 7 |
OMIM | 6 | 0 | 0 | 0 | 0 | 0 | 6 |
GeneReviews | 0 | 0 | 0 | 0 | 0 | 4 | 4 |
Database of Curated Mutations (DoCM) | 0 | 4 | 0 | 0 | 0 | 0 | 4 |
Baylor Genetics | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Mendelics | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Biochemical Molecular Genetic Laboratory, King Abdulaziz Medical City | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
New York Genome Center | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Genome-Nilou Lab | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
3billion | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Molecular Genetics, Royal Melbourne Hospital | 0 | 0 | 1 | 0 | 0 | 0 | 1 |