Variants from University Health Network, Princess Margaret Cancer Centre

Minimum submission review status:		Collection method:
Minimum conflict level: Report conflict between different conditions
Gene type: Distinguish antisense genes from sense genes
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic	likely pathogenic	uncertain significance	likely benign	benign	total
25	2	2	0	0	29

Gene and significance breakdown #

Total genes and gene combinations: 9

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Gene or gene combination	pathogenic	likely pathogenic	uncertain significance	total
TP53	17	1	0	18
APC	2	0	0	2
BRCA1	2	0	0	2
CHEK2	0	1	1	2
PTEN	2	0	0	2
ARID1A, LOC129929837	0	0	1	1
ATM	1	0	0	1
ATM, C11orf65	1	0	0	1
KRAS	1	0	0	1

Condition and significance breakdown #

Total conditions: 14

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Condition	pathogenic	likely pathogenic	uncertain significance	total
Neoplasm of ovary	9	1	0	10
Familial cancer of breast	6	1	0	7
B-cell chronic lymphocytic leukemia	2	0	0	2
Colorectal cancer	2	0	0	2
Familial cancer of breast; Neoplasm of ovary; Lung cancer	1	0	1	2
PTEN hamartoma tumor syndrome	2	0	0	2
Primary low grade serous adenocarcinoma of ovary	1	0	1	2
Acquired polycythemia vera; Endometrial serous adenocarcinoma	1	0	0	1
Ductal carcinoma in situ	1	0	0	1
Familial cancer of breast; Classic Hodgkin lymphoma; Neoplasm of ovary; Thyroid cancer, nonmedullary, 1	1	0	0	1
Familial cancer of breast; Neoplasm of ovary	1	0	0	1
Malignant tumor of prostate	1	0	0	1
Multiple myeloma; Colorectal cancer	1	0	0	1
not specified	1	0	0	1

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