ClinVar Miner

Variants in gene AGRN with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic) 		Variants with a confidence conflict
(e.g. benign vs likely benign) 		Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects) 		Variants with a clinically significant conflict
(e.g. benign vs pathogenic) 		Variants with any conflict
1918 98 0 47 18 0 6 67

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 2 4 2 0
likely pathogenic 2 0 1 0 0
uncertain significance 4 1 0 17 4
likely benign 2 0 17 0 45
benign 0 0 4 45 0

All variants with conflicting interpretations #

Total variants: 67
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_198576.4(AGRN):c.5358T>C (p.Gly1786=) rs17160781 0.08292
NM_198576.4(AGRN):c.3516+10G>C rs76264143 0.05034
NM_198576.4(AGRN):c.4996G>A (p.Val1666Ile) rs17160775 0.04750
NM_198576.4(AGRN):c.1058A>G (p.Gln353Arg) rs150359724 0.01713
NM_198576.4(AGRN):c.4740C>T (p.Arg1580=) rs115019873 0.01570
NM_198576.4(AGRN):c.3570C>T (p.Arg1190=) rs75361935 0.01197
NM_198576.4(AGRN):c.2025C>G (p.Gly675=) rs28484890 0.01118
NM_198576.4(AGRN):c.2406C>T (p.Gly802=) rs75774767 0.01095
NM_198576.4(AGRN):c.4452C>T (p.Thr1484=) rs75767981 0.01049
NM_198576.4(AGRN):c.1528G>A (p.Gly510Ser) rs138288952 0.00834
NM_198576.4(AGRN):c.4695G>C (p.Gln1565His) rs199876002 0.00827
NM_198576.4(AGRN):c.738C>T (p.Asp246=) rs536085218 0.00811
NM_198576.4(AGRN):c.5223C>T (p.Gly1741=) rs147681220 0.00805
NM_198576.4(AGRN):c.3964C>T (p.Arg1322Trp) rs184970403 0.00799
NM_198576.4(AGRN):c.3972G>A (p.Pro1324=) rs201483077 0.00799
NM_198576.4(AGRN):c.4540G>A (p.Ala1514Thr) rs111818381 0.00781
NM_198576.4(AGRN):c.1660G>A (p.Val554Met) rs79016973 0.00706
NM_198576.4(AGRN):c.5726G>C (p.Ser1909Thr) rs74685771 0.00700
NM_198576.4(AGRN):c.1603+19G>A rs115191992 0.00697
NM_198576.4(AGRN):c.5598C>T (p.Thr1866=) rs17778478 0.00691
NM_198576.4(AGRN):c.3077C>A (p.Thr1026Asn) rs3813188 0.00690
NM_198576.4(AGRN):c.3465T>C (p.Ala1155=) rs146358566 0.00657
NM_198576.4(AGRN):c.3866C>T (p.Pro1289Leu) rs139294803 0.00637
NM_198576.4(AGRN):c.5353G>A (p.Asp1785Asn) rs144245019 0.00636
NM_198576.4(AGRN):c.3404A>G (p.Gln1135Arg) rs142416636 0.00588
NM_198576.4(AGRN):c.67G>C (p.Val23Leu) rs201073369 0.00583
NM_198576.4(AGRN):c.5352C>T (p.Phe1784=) rs112073270 0.00537
NM_198576.4(AGRN):c.5025C>T (p.Gly1675=) rs147990356 0.00536
NM_198576.4(AGRN):c.1123G>T (p.Ala375Ser) rs138031468 0.00517
NM_198576.4(AGRN):c.4352C>T (p.Pro1451Leu) rs144620006 0.00426
NM_198576.4(AGRN):c.4285C>T (p.Arg1429Cys) rs201346452 0.00327
NM_198576.4(AGRN):c.4839C>T (p.Cys1613=) rs113020870 0.00302
NM_198576.4(AGRN):c.1993G>A (p.Glu665Lys) rs143324306 0.00297
NM_198576.4(AGRN):c.2067G>A (p.Gln689=) rs139886237 0.00288
NM_198576.4(AGRN):c.4639G>A (p.Glu1547Lys) rs2799068 0.00284
NM_198576.4(AGRN):c.1434G>A (p.Thr478=) rs147346337 0.00281
NM_198576.4(AGRN):c.800C>T (p.Thr267Met) rs566673314 0.00265
NM_198576.4(AGRN):c.773C>T (p.Thr258Ile) rs200607541 0.00231
NM_198576.4(AGRN):c.4131C>T (p.Phe1377=) rs368555478 0.00225
NM_198576.4(AGRN):c.1394C>T (p.Pro465Leu) rs116586548 0.00216
NM_198576.4(AGRN):c.2690C>T (p.Ala897Val) rs116836855 0.00203
NM_198576.4(AGRN):c.1570C>T (p.Arg524Trp) rs144164397 0.00119
NM_198576.4(AGRN):c.3765G>A (p.Ala1255=) rs149490453 0.00113
NM_198576.4(AGRN):c.4840G>A (p.Glu1614Lys) rs147259096 0.00113
NM_198576.4(AGRN):c.1188G>A (p.Pro396=) rs138841641 0.00103
NM_198576.4(AGRN):c.2501G>A (p.Arg834Gln) rs146243145 0.00094
NM_198576.4(AGRN):c.2013C>T (p.Ser671=) rs141603403 0.00093
NM_198576.4(AGRN):c.2266G>A (p.Ala756Thr) rs140764403 0.00079
NM_198576.4(AGRN):c.4323G>A (p.Ala1441=) rs373287346 0.00066
NM_198576.4(AGRN):c.1198C>T (p.Arg400Trp) rs149636063 0.00032
NM_198576.4(AGRN):c.2563G>A (p.Val855Met) rs200684031 0.00027
NM_198576.4(AGRN):c.3732C>T (p.His1244=) rs536657086 0.00017
NM_198576.4(AGRN):c.1384+6C>T rs763495287 0.00013
NM_198576.4(AGRN):c.1557C>T (p.Ala519=) rs146185843 0.00012
NM_198576.4(AGRN):c.1343G>A (p.Arg448Gln) rs772102866 0.00009
NM_198576.4(AGRN):c.4735G>A (p.Gly1579Ser) rs556296275 0.00006
NM_198576.4(AGRN):c.2647G>A (p.Gly883Ser) rs145162376 0.00005
NM_198576.4(AGRN):c.4298+11A>T rs369279324 0.00005
NM_198576.4(AGRN):c.526C>T (p.Leu176=) rs544749044 0.00005
NM_198576.4(AGRN):c.4999G>A (p.Val1667Met) rs770750909 0.00003
NM_198576.4(AGRN):c.749A>C (p.Asn250Thr) rs753435616 0.00003
NM_198576.4(AGRN):c.5023G>A (p.Gly1675Ser) rs764160563 0.00001
NM_198576.4(AGRN):c.2457G>C (p.Gly819=) rs112039851
NM_198576.4(AGRN):c.3264G>C (p.Leu1088Phe) rs150132566
NM_198576.4(AGRN):c.4021G>A (p.Gly1341Arg) rs372543866
NM_198576.4(AGRN):c.4779_4793del (p.Gln1593_Cys1597del) rs769494139
NM_198576.4(AGRN):c.5011C>T (p.Arg1671Ter)

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