ClinVar Miner

Variants in gene ALK with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
650 82 6 52 17 4 2 73

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor
pathogenic 6 8 2 0 0 4
likely pathogenic 8 0 0 0 0 3
uncertain significance 2 0 0 16 2 0
likely benign 0 0 16 0 44 0
benign 0 0 2 44 0 0
risk factor 4 3 0 0 0 0

All variants with conflicting interpretations #

Total variants: 73
Download table as spreadsheet
HGVS dbSNP
NM_004304.4(ALK):c.-5G>A rs56270786
NM_004304.4(ALK):c.1110G>A (p.Glu370=) rs138784554
NM_004304.4(ALK):c.1111G>A (p.Ala371Thr) rs149968229
NM_004304.4(ALK):c.1234C>T (p.Arg412Cys) rs147102592
NM_004304.4(ALK):c.1283-5T>C rs377214413
NM_004304.4(ALK):c.1427T>C (p.Val476Ala) rs35093491
NM_004304.4(ALK):c.1464C>T (p.Gly488=) rs56165377
NM_004304.4(ALK):c.1626G>C (p.Pro542=) rs143916398
NM_004304.4(ALK):c.1719C>T (p.Thr573=) rs74830770
NM_004304.4(ALK):c.1943C>T (p.Thr648Ile) rs116202066
NM_004304.4(ALK):c.2011C>T (p.Pro671Ser) rs145780832
NM_004304.4(ALK):c.2039C>T (p.Thr680Ile) rs35228363
NM_004304.4(ALK):c.2109C>T (p.Asn703=) rs560163657
NM_004304.4(ALK):c.2127C>A (p.Asn709Lys) rs376175333
NM_004304.4(ALK):c.2133C>T (p.Ser711=) rs77102810
NM_004304.4(ALK):c.2148C>T (p.Ser716=) rs55733526
NM_004304.4(ALK):c.2149G>A (p.Glu717Lys) rs147858673
NM_004304.4(ALK):c.2175C>T (p.Ile725=) rs57881134
NM_004304.4(ALK):c.2210C>T (p.Ser737Leu) rs368581969
NM_004304.4(ALK):c.2268C>T (p.Gly756=) rs149853746
NM_004304.4(ALK):c.2430C>T (p.Ser810=) rs150292405
NM_004304.4(ALK):c.2451C>T (p.Gly817=) rs183314518
NM_004304.4(ALK):c.2526C>T (p.Ala842=) rs145271283
NM_004304.4(ALK):c.2577G>C (p.Glu859Asp) rs61754865
NM_004304.4(ALK):c.2613C>T (p.Asn871=) rs150557024
NM_004304.4(ALK):c.2676C>T (p.Ala892=) rs138668699
NM_004304.4(ALK):c.267C>A (p.Gly89=) rs192127241
NM_004304.4(ALK):c.3035C>T (p.Thr1012Met) rs35073634
NM_004304.4(ALK):c.3057C>A (p.Val1019=) rs138406372
NM_004304.4(ALK):c.310C>A (p.Pro104Thr) rs576431612
NM_004304.4(ALK):c.3173-11C>T rs79339096
NM_004304.4(ALK):c.3260C>T (p.Thr1087Ile) rs113994090
NM_004304.4(ALK):c.3271G>A (p.Asp1091Asn) rs864309584
NM_004304.4(ALK):c.3291C>T (p.Cys1097=) rs370170353
NM_004304.4(ALK):c.3336G>A (p.Pro1112=) rs146074150
NM_004304.4(ALK):c.3383G>C (p.Gly1128Ala) rs113994088
NM_004304.4(ALK):c.3408C>T (p.Ser1136=) rs56146053
NM_004304.4(ALK):c.3452C>T (p.Thr1151Met) rs113994091
NM_004304.4(ALK):c.3520T>C (p.Phe1174Leu) rs281864719
NM_004304.4(ALK):c.3520T>G (p.Phe1174Val) rs281864719
NM_004304.4(ALK):c.3522C>A (p.Phe1174Leu) rs863225281
NM_004304.4(ALK):c.3522C>G (p.Phe1174Leu) rs863225281
NM_004304.4(ALK):c.3575G>C (p.Arg1192Pro) rs113994089
NM_004304.4(ALK):c.3594C>T (p.Leu1198=) rs56071005
NM_004304.4(ALK):c.3600G>A (p.Ala1200=) rs56247462
NM_004304.4(ALK):c.3600G>C (p.Ala1200=) rs56247462
NM_004304.4(ALK):c.3633C>A (p.Thr1211=) rs144437923
NM_004304.4(ALK):c.3645G>A (p.Pro1215=) rs775768862
NM_004304.4(ALK):c.3733T>A (p.Phe1245Ile) rs281864720
NM_004304.4(ALK):c.3733T>G (p.Phe1245Val) rs281864720
NM_004304.4(ALK):c.3749T>C (p.Ile1250Thr) rs113994092
NM_004304.4(ALK):c.3824G>A (p.Arg1275Gln) rs113994087
NM_004304.4(ALK):c.3839C>T (p.Ala1280Val) rs74716434
NM_004304.4(ALK):c.384G>A (p.Lys128=) rs753267950
NM_004304.4(ALK):c.3939-8A>G rs3738869
NM_004304.4(ALK):c.4203T>C (p.Tyr1401=) rs55772745
NM_004304.4(ALK):c.4303_4305delGAG (p.Glu1435del) rs138827116
NM_004304.4(ALK):c.4338C>T (p.Thr1446=) rs56132472
NM_004304.4(ALK):c.4344C>T (p.Ser1448=) rs886055929
NM_004304.4(ALK):c.4375G>T (p.Ala1459Ser) rs372612147
NM_004304.4(ALK):c.4480G>A (p.Gly1494Arg) rs199940609
NM_004304.4(ALK):c.4573A>G (p.Lys1525Glu) rs139437088
NM_004304.4(ALK):c.4596C>T (p.Asn1532=) rs1881422
NM_004304.4(ALK):c.4785C>T (p.Ala1595=) rs76150405
NM_004304.4(ALK):c.4836G>A (p.Lys1612=) rs78174819
NM_004304.4(ALK):c.487G>T (p.Val163Leu) rs55697431
NM_004304.4(ALK):c.597C>T (p.Gly199=) rs200868013
NM_004304.4(ALK):c.645T>C (p.Leu215=) rs115392387
NM_004304.4(ALK):c.72G>A (p.Gly24=) rs756782371
NM_004304.4(ALK):c.776G>A (p.Arg259His) rs138686378
NM_004304.4(ALK):c.846C>T (p.Asp282=) rs56116528
NM_004304.4(ALK):c.932G>A (p.Arg311His) rs150966028
NM_004304.5(ALK):c.3837-9_3837-7dup rs373764155

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