ClinVar Miner

Variants in gene ALK with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
1860 104 4 16 24 4 3 45

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic uncertain significance likely benign benign risk factor
pathogenic 4 3 1 0 4
uncertain significance 3 0 24 0 1
likely benign 1 24 0 16 1
benign 0 0 16 0 0
risk factor 4 1 1 0 0

All variants with conflicting interpretations #

Total variants: 45
Download table as spreadsheet
HGVS dbSNP
NM_004304.5(ALK):c.-5G>A rs56270786
NM_004304.5(ALK):c.1044C>T (p.Ala348=) rs200293454
NM_004304.5(ALK):c.1183C>T (p.Arg395Cys) rs779282861
NM_004304.5(ALK):c.1234C>T (p.Arg412Cys) rs147102592
NM_004304.5(ALK):c.1550A>G (p.His517Arg) rs367674546
NM_004304.5(ALK):c.2039C>T (p.Thr680Ile) rs35228363
NM_004304.5(ALK):c.2073C>T (p.Ser691=) rs370435082
NM_004304.5(ALK):c.2149G>A (p.Glu717Lys) rs147858673
NM_004304.5(ALK):c.2304T>C (p.Asp768=) rs758649392
NM_004304.5(ALK):c.2451C>T (p.Gly817=) rs183314518
NM_004304.5(ALK):c.2478C>T (p.Tyr826=) rs142126984
NM_004304.5(ALK):c.2632+8G>A rs199653862
NM_004304.5(ALK):c.2901C>A (p.Thr967=) rs886055930
NM_004304.5(ALK):c.2928C>T (p.His976=) rs75895956
NM_004304.5(ALK):c.3057C>A (p.Val1019=) rs138406372
NM_004304.5(ALK):c.310C>T (p.Pro104Ser) rs576431612
NM_004304.5(ALK):c.3173-11C>T rs79339096
NM_004304.5(ALK):c.3260C>T (p.Thr1087Ile) rs113994090
NM_004304.5(ALK):c.3291C>T (p.Cys1097=) rs370170353
NM_004304.5(ALK):c.3383G>C (p.Gly1128Ala) rs113994088
NM_004304.5(ALK):c.3452C>T (p.Thr1151Met) rs113994091
NM_004304.5(ALK):c.3520T>G (p.Phe1174Val) rs281864719
NM_004304.5(ALK):c.3575G>C (p.Arg1192Pro) rs113994089
NM_004304.5(ALK):c.3594C>T (p.Leu1198=) rs56071005
NM_004304.5(ALK):c.3749T>C (p.Ile1250Thr) rs113994092
NM_004304.5(ALK):c.3824G>A (p.Arg1275Gln) rs113994087
NM_004304.5(ALK):c.3837-9_3837-7dup rs373764155
NM_004304.5(ALK):c.386G>T (p.Gly129Val) rs760041708
NM_004304.5(ALK):c.3939-9C>T rs749848775
NM_004304.5(ALK):c.4275G>A (p.Leu1425=) rs749418931
NM_004304.5(ALK):c.4297GAG[2] (p.Glu1435del) rs138827116
NM_004304.5(ALK):c.4344C>T (p.Ser1448=) rs886055929
NM_004304.5(ALK):c.4375G>T (p.Ala1459Ser) rs372612147
NM_004304.5(ALK):c.4425C>T (p.His1475=) rs139039449
NM_004304.5(ALK):c.4473G>A (p.Lys1491=) rs148987382
NM_004304.5(ALK):c.4608G>A (p.Glu1536=) rs147241767
NM_004304.5(ALK):c.469C>T (p.Pro157Ser) rs74774946
NM_004304.5(ALK):c.4785C>T (p.Ala1595=) rs76150405
NM_004304.5(ALK):c.4795C>T (p.Pro1599Ser) rs373037272
NM_004304.5(ALK):c.4796C>A (p.Pro1599His) rs1881423
NM_004304.5(ALK):c.4809T>C (p.His1603=) rs758502850
NM_004304.5(ALK):c.597C>T (p.Gly199=) rs200868013
NM_004304.5(ALK):c.615C>A (p.Ser205=)
NM_004304.5(ALK):c.615C>G (p.Ser205=) rs567498111
NM_004304.5(ALK):c.872G>A (p.Arg291His) rs572340007

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.