ClinVar Miner

Variants in gene BRAF with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
217 58 8 64 14 0 6 83

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 2 43 2 0 0
likely pathogenic 43 0 6 0 0
uncertain significance 2 6 0 10 5
likely benign 0 0 10 0 21
benign 0 0 5 21 6

All variants with conflicting interpretations #

Total variants: 83
Download table as spreadsheet
HGVS dbSNP
NM_001354609.1(BRAF):c.1574T>C (p.Leu525Pro) rs869025340
NM_004333.4(BRAF):c.*7T>C rs727502903
NM_004333.4(BRAF):c.-19C>T rs71645935
NM_004333.4(BRAF):c.1391G>A (p.Gly464Glu) rs121913348
NM_004333.4(BRAF):c.1397G>T (p.Gly466Val) rs121913351
NM_004333.4(BRAF):c.1405G>C (p.Gly469Arg) rs121913357
NM_004333.4(BRAF):c.1406G>C (p.Gly469Ala) rs121913355
NM_004333.4(BRAF):c.1406G>T (p.Gly469Val) rs121913355
NM_004333.4(BRAF):c.1411G>T (p.Val471Phe) rs121913376
NM_004333.4(BRAF):c.1460T>G (p.Val487Gly) rs397516893
NM_004333.4(BRAF):c.1501G>A (p.Glu501Lys) rs180177038
NM_004333.4(BRAF):c.1743T>A (p.Asn581Lys) rs397516895
NM_004333.4(BRAF):c.1780G>A (p.Asp594Asn) rs397516896
NM_004333.4(BRAF):c.1780G>C (p.Asp594His) rs397516896
NM_004333.4(BRAF):c.1781A>G (p.Asp594Gly) rs121913338
NM_004333.4(BRAF):c.1786G>C (p.Gly596Arg) rs121913361
NM_004333.4(BRAF):c.1790T>G (p.Leu597Arg) rs121913366
NM_004333.4(BRAF):c.1796C>T (p.Thr599Ile) rs121913375
NM_004333.4(BRAF):c.1802A>C (p.Lys601Thr) rs397507484
NM_004333.4(BRAF):c.2128-4G>T rs956143558
NM_004333.4(BRAF):c.2128-5delT rs373442098
NM_004333.4(BRAF):c.2128-5dupT rs373442098
NM_004333.4(BRAF):c.2136C>T (p.Ala712=) rs377165711
NM_004333.4(BRAF):c.721A>C (p.Thr241Pro) rs387906661
NM_004333.4(BRAF):c.722C>T (p.Thr241Met) rs387906660
NM_004333.4(BRAF):c.723G>A (p.Thr241=) rs369182143
NM_004333.4(BRAF):c.981-14C>A rs200002171
NM_004333.5(BRAF):c.-5A>G rs71645936
NM_004333.5(BRAF):c.1024A>G (p.Ile342Val) rs201481342
NM_004333.5(BRAF):c.1068A>G (p.Gln356=) rs143335467
NM_004333.5(BRAF):c.111G>A (p.Ser37=) rs727502906
NM_004333.5(BRAF):c.1150A>G (p.Arg384Gly) rs545495379
NM_004333.5(BRAF):c.1207C>G (p.Pro403Ala) rs749792302
NM_004333.5(BRAF):c.1227A>G (p.Ser409=) rs145035762
NM_004333.5(BRAF):c.1332G>A (p.Arg444=) rs56101602
NM_004333.5(BRAF):c.1383A>G (p.Gln461=) rs56216404
NM_004333.5(BRAF):c.1390G>A (p.Gly464Arg) rs121913349
NM_004333.5(BRAF):c.1391G>T (p.Gly464Val) rs121913348
NM_004333.5(BRAF):c.1406G>A (p.Gly469Glu) rs121913355
NM_004333.5(BRAF):c.1433-19A>G rs369635503
NM_004333.5(BRAF):c.1454T>C (p.Leu485Ser) rs397507475
NM_004333.5(BRAF):c.1455G>T (p.Leu485Phe) rs180177036
NM_004333.5(BRAF):c.1495A>G (p.Lys499Glu) rs180177037
NM_004333.5(BRAF):c.1497A>C (p.Lys499Asn) rs397507476
NM_004333.5(BRAF):c.1502A>G (p.Glu501Gly) rs180177039
NM_004333.5(BRAF):c.1502A>T (p.Glu501Val) rs180177039
NM_004333.5(BRAF):c.1595G>A (p.Cys532Tyr) rs397507479
NM_004333.5(BRAF):c.1600G>C (p.Gly534Arg) rs180177041
NM_004333.5(BRAF):c.1694+14G>A rs184144181
NM_004333.5(BRAF):c.1756G>A (p.Glu586Lys) rs121913340
NM_004333.5(BRAF):c.1783T>C (p.Phe595Leu) rs794729219
NM_004333.5(BRAF):c.1785T>A (p.Phe595Leu) rs121913341
NM_004333.5(BRAF):c.1785T>G (p.Phe595Leu) rs121913341
NM_004333.5(BRAF):c.1787G>T (p.Gly596Val) rs397507483
NM_004333.5(BRAF):c.1789C>G (p.Leu597Val) rs121913369
NM_004333.5(BRAF):c.1790T>A (p.Leu597Gln) rs121913366
NM_004333.5(BRAF):c.1798G>A (p.Val600Met) rs121913378
NM_004333.5(BRAF):c.1799T>A (p.Val600Glu) rs113488022
NM_004333.5(BRAF):c.1801A>G (p.Lys601Glu) rs121913364
NM_004333.5(BRAF):c.1914T>A (p.Asp638Glu) rs180177042
NM_004333.5(BRAF):c.1992+16G>C rs3789806
NM_004333.5(BRAF):c.2127+3A>G rs371976102
NM_004333.5(BRAF):c.2235A>G (p.Leu745=) rs56046546
NM_004333.5(BRAF):c.36G>A (p.Ala12=) rs397507454
NM_004333.5(BRAF):c.375T>G (p.Ser125=) rs201507202
NM_004333.5(BRAF):c.399A>G (p.Ser133=) rs397507463
NM_004333.5(BRAF):c.483G>C (p.Leu161=) rs61730029
NM_004333.5(BRAF):c.622A>G (p.Ile208Val) rs727504571
NM_004333.5(BRAF):c.64G>A (p.Asp22Asn) rs397507456
NM_004333.5(BRAF):c.68T>A (p.Met23Lys)
NM_004333.5(BRAF):c.708C>T (p.Asn236=) rs138333692
NM_004333.5(BRAF):c.755G>C (p.Arg252Pro) rs1325951163
NM_004333.5(BRAF):c.769C>A (p.Gln257Lys) rs397507469
NM_004333.5(BRAF):c.785A>C (p.Gln262Pro) rs397516904
NM_004333.5(BRAF):c.78G>T (p.Glu26Asp) rs371877084
NM_004333.5(BRAF):c.918C>G (p.Ser306=) rs794727865
NM_004333.5(BRAF):c.92C>G (p.Ala31Gly) rs397516906
NM_004333.5(BRAF):c.95_100del (p.Gly32_Ala33del) rs397507458
NM_004333.5(BRAF):c.968C>T (p.Ser323Leu) rs397516907
NM_004333.5(BRAF):c.976A>G (p.Ile326Val) rs775040765
NM_004333.6(BRAF):c.735A>C (p.Leu245Phe) rs397507466
NM_004333.6(BRAF):c.735A>T (p.Leu245Phe) rs397507466
NM_004333.6(BRAF):c.739T>G (p.Phe247Val) rs397516903

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