ClinVar Miner

Variants in gene BRAF with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
366 51 4 35 10 2 11 58

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign drug response
pathogenic 0 19 6 0 0 1
likely pathogenic 19 0 5 0 0 0
uncertain significance 6 5 0 7 4 2
likely benign 0 0 7 0 16 0
benign 0 0 4 16 4 0
drug response 1 0 2 0 0 0

All variants with conflicting interpretations #

Total variants: 58
Download table as spreadsheet
HGVS dbSNP
NM_001374258.1(BRAF):c.-19C>T rs71645935
NM_001374258.1(BRAF):c.1068A>G (p.Gln356=) rs143335467
NM_001374258.1(BRAF):c.111G>A (p.Ser37=) rs727502906
NM_001374258.1(BRAF):c.1452G>A (p.Arg484=) rs56101602
NM_001374258.1(BRAF):c.1503A>G (p.Gln501=) rs56216404
NM_001374258.1(BRAF):c.1511G>A (p.Gly504Glu) rs121913348
NM_001374258.1(BRAF):c.1517G>T (p.Gly506Val) rs121913351
NM_001374258.1(BRAF):c.1529C>G (p.Thr510Arg) rs397516891
NM_001374258.1(BRAF):c.1553-19A>G rs369635503
NM_001374258.1(BRAF):c.1621G>A (p.Glu541Lys) rs180177038
NM_001374258.1(BRAF):c.1715G>A (p.Cys572Tyr) rs397507479
NM_001374258.1(BRAF):c.1720G>C (p.Gly574Arg) rs180177041
NM_001374258.1(BRAF):c.1814+14G>A rs184144181
NM_001374258.1(BRAF):c.1900G>A (p.Asp634Asn) rs397516896
NM_001374258.1(BRAF):c.1901A>G (p.Asp634Gly) rs121913338
NM_001374258.1(BRAF):c.1903T>C (p.Phe635Leu) rs794729219
NM_001374258.1(BRAF):c.1910T>A (p.Leu637Gln) rs121913366
NM_001374258.1(BRAF):c.1919T>A (p.Val640Glu) rs113488022
NM_001374258.1(BRAF):c.2247+3A>G rs371976102
NM_001374258.1(BRAF):c.2248-5del rs373442098
NM_001374258.1(BRAF):c.2256C>T (p.Ala752=) rs377165711
NM_001374258.1(BRAF):c.2355A>G (p.Leu785=) rs56046546
NM_001374258.1(BRAF):c.375T>G (p.Ser125=) rs201507202
NM_001374258.1(BRAF):c.483G>C (p.Leu161=) rs61730029
NM_001374258.1(BRAF):c.622A>G (p.Ile208Val) rs727504571
NM_001374258.1(BRAF):c.64G>A (p.Asp22Asn) rs397507456
NM_001374258.1(BRAF):c.708C>T (p.Asn236=) rs138333692
NM_001374258.1(BRAF):c.721A>C (p.Thr241Pro) rs387906661
NM_001374258.1(BRAF):c.722C>A (p.Thr241Lys) rs387906660
NM_001374258.1(BRAF):c.722C>T (p.Thr241Met) rs387906660
NM_001374258.1(BRAF):c.735A>C (p.Leu245Phe) rs397507466
NM_001374258.1(BRAF):c.735A>T (p.Leu245Phe) rs397507466
NM_001374258.1(BRAF):c.739T>G (p.Phe247Val) rs397516903
NM_001374258.1(BRAF):c.78G>T (p.Glu26Asp) rs371877084
NM_001374258.1(BRAF):c.793G>C (p.Gly265Arg) rs397516905
NM_001374258.1(BRAF):c.83GCGCCG[4] (p.28GA[4]) rs397507458
NM_001374258.1(BRAF):c.92C>G (p.Ala31Gly) rs397516906
NM_001374258.1(BRAF):c.968C>T (p.Ser323Leu) rs397516907
NM_004333.6(BRAF):c.-5A>G rs71645936
NM_004333.6(BRAF):c.1150A>G (p.Arg384Gly) rs545495379
NM_004333.6(BRAF):c.1207C>G (p.Pro403Ala) rs749792302
NM_004333.6(BRAF):c.138+17C>G rs756400234
NM_004333.6(BRAF):c.1495A>G (p.Lys499Glu) rs180177037
NM_004333.6(BRAF):c.1497A>C (p.Lys499Asn) rs397507476
NM_004333.6(BRAF):c.1574T>C (p.Leu525Pro) rs869025340
NM_004333.6(BRAF):c.1780G>C (p.Asp594His) rs397516896
NM_004333.6(BRAF):c.1781A>T (p.Asp594Val) rs121913338
NM_004333.6(BRAF):c.1790T>G (p.Leu597Arg) rs121913366
NM_004333.6(BRAF):c.1794_1796dup (p.Thr599dup) rs727502902
NM_004333.6(BRAF):c.1798_1799delinsAA (p.Val600Lys) rs121913227
NM_004333.6(BRAF):c.1799T>G (p.Val600Gly) rs113488022
NM_004333.6(BRAF):c.1860+16A>G rs368859030
NM_004333.6(BRAF):c.36G>A (p.Ala12=) rs397507454
NM_004333.6(BRAF):c.399A>G (p.Ser133=) rs397507463
NM_004333.6(BRAF):c.755G>C (p.Arg252Pro) rs1325951163
NM_004333.6(BRAF):c.826G>C (p.Val276Leu) rs1057518105
NM_004333.6(BRAF):c.918C>G (p.Ser306=) rs794727865
NM_004333.6(BRAF):c.976A>G (p.Ile326Val) rs775040765

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