ClinVar Miner

Variants in gene DNMT3B with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
255 20 0 4 12 0 2 18

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

likely pathogenic uncertain significance likely benign benign
likely pathogenic 0 2 0 0
uncertain significance 2 0 10 2
likely benign 0 10 0 4
benign 0 2 4 0

All variants with conflicting interpretations #

Total variants: 18
Download table as spreadsheet
HGVS dbSNP
NM_006892.4(DNMT3B):c.1035C>T (p.Ile345=) rs150148922
NM_006892.4(DNMT3B):c.1150G>A (p.Ala384Thr) rs150682895
NM_006892.4(DNMT3B):c.1337T>C (p.Phe446Ser) rs150736372
NM_006892.4(DNMT3B):c.1359G>A (p.Gly453=) rs35216603
NM_006892.4(DNMT3B):c.143-9C>G rs377138079
NM_006892.4(DNMT3B):c.1490+9T>C rs370659978
NM_006892.4(DNMT3B):c.1760-8C>T rs2424926
NM_006892.4(DNMT3B):c.1996+7A>G rs556202476
NM_006892.4(DNMT3B):c.1996+9C>T rs143448185
NM_006892.4(DNMT3B):c.2142G>A (p.Leu714=) rs143847495
NM_006892.4(DNMT3B):c.2292G>T (p.Arg764Ser) rs759448571
NM_006892.4(DNMT3B):c.408C>T (p.Ser136=) rs111877243
NM_006892.4(DNMT3B):c.42C>T (p.Ala14=) rs730823
NM_006892.4(DNMT3B):c.608C>T (p.Pro203Leu) rs147945634
NM_006892.4(DNMT3B):c.684C>T (p.Leu228=) rs373811098
NM_006892.4(DNMT3B):c.720C>T (p.Pro240=) rs200921151
NM_006892.4(DNMT3B):c.886G>A (p.Val296Ile) rs145632647
NM_006892.4(DNMT3B):c.922-8C>T rs200508870

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