ClinVar Miner

Variants in gene DPYD with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
235 23 0 10 4 3 7 18

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign drug response other
pathogenic 0 6 4 0 0 3 1
likely pathogenic 6 0 5 0 0 0 0
uncertain significance 4 5 0 3 2 0 0
likely benign 0 0 3 0 4 0 0
benign 0 0 2 4 0 0 0
drug response 3 0 0 0 0 0 1
other 1 0 0 0 0 1 0

All variants with conflicting interpretations #

Total variants: 18
Download table as spreadsheet
NM_000110.3(DPYD):c.1475C>T (p.Ser492Leu) rs72549304
NM_000110.3(DPYD):c.1774C>T (p.Arg592Trp) rs59086055
NM_000110.3(DPYD):c.2275C>T (p.Arg759Ter) rs759372918
NM_000110.3(DPYD):c.2303C>A (p.Thr768Lys) rs56005131
NM_000110.3(DPYD):c.2657G>A (p.Arg886His) rs1801267
NM_000110.3(DPYD):c.661G>T (p.Glu221Ter) rs146170505
NM_000110.3(DPYD):c.763-2A>G rs1300669537
NM_000110.3(DPYD):c.775A>G (p.Lys259Glu) rs45589337
NM_000110.4(DPYD):c.1601G>A (p.Ser534Asn) rs1801158
NM_000110.4(DPYD):c.1679T>G (p.Ile560Ser) rs55886062
NM_000110.4(DPYD):c.1905+1G>A rs3918290
NM_000110.4(DPYD):c.2180-3T>C rs74104343
NM_000110.4(DPYD):c.2846A>T (p.Asp949Val) rs67376798
NM_000110.4(DPYD):c.557A>G (p.Tyr186Cys) rs115232898
NM_001160301.1(DPYD):c.187A>G (p.Lys63Glu) rs367619008
NM_001160301.1(DPYD):c.208C>T (p.Arg70Ter) rs141597515
NM_001160301.1(DPYD):c.220C>T (p.Arg74Ter) rs189768576
NM_001160301.1(DPYD):c.451A>G (p.Asn151Asp) rs200562975

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