ClinVar Miner

Variants in gene FLCN with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
968 65 6 15 13 0 3 30

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 2 7 2 0 0
likely pathogenic 7 0 2 0 0
uncertain significance 2 2 3 11 4
likely benign 0 0 11 0 8
benign 0 0 4 8 1

All variants with conflicting interpretations #

Total variants: 30
Download table as spreadsheet
HGVS dbSNP
NM_144997.7(FLCN):c.1149C>T (p.Leu383=) rs150752548
NM_144997.7(FLCN):c.1177-5_1177-3del rs767671406
NM_144997.7(FLCN):c.1269C>T (p.His423=) rs41464156
NM_144997.7(FLCN):c.1281C>G (p.Pro427=) rs372207262
NM_144997.7(FLCN):c.1285del (p.His429fs) rs80338682
NM_144997.7(FLCN):c.1285dup (p.His429fs) rs80338682
NM_144997.7(FLCN):c.1300+1G>A rs879255676
NM_144997.7(FLCN):c.1333G>A (p.Ala445Thr) rs41419545
NM_144997.7(FLCN):c.1428C>G (p.Asp476Glu) rs756944795
NM_144997.7(FLCN):c.1432+1G>A rs755959303
NM_144997.7(FLCN):c.1463C>T (p.Ala488Val) rs200660337
NM_144997.7(FLCN):c.1522_1524del (p.Lys508del) rs398124529
NM_144997.7(FLCN):c.1523A>G (p.Lys508Arg) rs199643834
NM_144997.7(FLCN):c.1579C>T (p.Arg527Ter) rs879255683
NM_144997.7(FLCN):c.1580G>A (p.Arg527Gln) rs777826268
NM_144997.7(FLCN):c.1597C>T (p.Gln533Ter) rs398124532
NM_144997.7(FLCN):c.1658G>A (p.Trp553Ter) rs879255684
NM_144997.7(FLCN):c.250-7T>C rs748857550
NM_144997.7(FLCN):c.268G>T (p.Ala90Ser) rs141140415
NM_144997.7(FLCN):c.3G>C (p.Met1Ile) rs879255658
NM_144997.7(FLCN):c.466TTC[1] (p.Phe157del) rs786203218
NM_144997.7(FLCN):c.580C>T (p.Arg194Trp) rs138070947
NM_144997.7(FLCN):c.592G>A (p.Asp198Asn) rs200168437
NM_144997.7(FLCN):c.708C>T (p.Asn236=) rs750394475
NM_144997.7(FLCN):c.715C>T (p.Arg239Cys) rs78683075
NM_144997.7(FLCN):c.871+16T>A rs116643153
NM_144997.7(FLCN):c.871+36G>A rs3744124
NM_144997.7(FLCN):c.871+47G>A rs142934950
NM_144997.7(FLCN):c.959G>A (p.Arg320Gln) rs143483053
NM_144997.7(FLCN):c.977C>T (p.Pro326Leu) rs138031155

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.