ClinVar Miner

Variants in gene GRM1 with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
256 48 0 27 6 0 0 33

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

uncertain significance likely benign benign
uncertain significance 0 6 0
likely benign 6 0 27
benign 0 27 0

All variants with conflicting interpretations #

Total variants: 33
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_001278064.2(GRM1):c.3168T>G (p.Gly1056=) rs6923864 0.64620
NM_001278064.2(GRM1):c.2977T>C (p.Ser993Pro) rs6923492 0.56892
NM_001278064.2(GRM1):c.3495C>A (p.Pro1165=) rs9373491 0.55222
NM_001278064.2(GRM1):c.2793G>A (p.Lys931=) rs2942 0.49950
NM_001278064.2(GRM1):c.2651G>A (p.Gly884Glu) rs362936 0.01411
NM_001278064.2(GRM1):c.2185C>A (p.Pro729Thr) rs41305288 0.01244
NM_001278064.2(GRM1):c.2785G>A (p.Val929Ile) rs2941 0.01171
NM_001278064.2(GRM1):c.3107G>T (p.Gly1036Val) rs144944927 0.00751
NM_001278064.2(GRM1):c.3214C>G (p.Pro1072Ala) rs146753539 0.00646
NM_001278064.2(GRM1):c.3206C>T (p.Pro1069Leu) rs79336287 0.00337
NM_001278064.2(GRM1):c.922G>A (p.Val308Ile) rs112915383 0.00277
NM_001278064.2(GRM1):c.2859C>T (p.Thr953=) rs116471335 0.00249
NM_001278064.2(GRM1):c.3161G>A (p.Gly1054Asp) rs145764886 0.00188
NM_001278064.2(GRM1):c.2991A>G (p.Ala997=) rs140244084 0.00118
NM_001278064.2(GRM1):c.1433+10T>C rs373538200 0.00111
NM_001278064.2(GRM1):c.444C>G (p.Pro148=) rs138794480 0.00071
NM_001278064.2(GRM1):c.2922T>C (p.Pro974=) rs142409803 0.00065
NM_001278064.2(GRM1):c.2581G>A (p.Gly861Ser) rs143544032 0.00056
NM_001278064.2(GRM1):c.2725A>C (p.Met909Leu) rs138759146 0.00020
NM_001278064.2(GRM1):c.2026G>A (p.Val676Met) rs752403373 0.00003
NM_001278064.2(GRM1):c.3300C>A (p.Ser1100Arg) rs1227591846 0.00001
NM_001278064.2(GRM1):c.3381G>A (p.Glu1127=) rs77895673 0.00001
NM_001278064.2(GRM1):c.2796C>G (p.Pro932=) rs1583494731
NM_001278064.2(GRM1):c.3138G>A (p.Pro1046=)
NM_001278064.2(GRM1):c.3213T>C (p.Pro1071=) rs1047006
NM_001278064.2(GRM1):c.3213T>G (p.Pro1071=) rs1047006
NM_001278064.2(GRM1):c.669T>C (p.Asn223=)
NM_001278064.2(GRM1):c.885A>C (p.Thr295=)
NM_001278064.2(GRM1):c.950+8TC[14] rs72225459
NM_001278064.2(GRM1):c.950+8TC[17] rs72225459
NM_001278064.2(GRM1):c.950+8TC[18] rs72225459
NM_001278064.2(GRM1):c.950+8TC[20] rs72225459
NM_001278064.2(GRM1):c.950+8TC[21] rs72225459

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