ClinVar Miner

Variants in gene LAMB1 with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
172 16 0 9 5 0 0 13

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

uncertain significance likely benign benign
uncertain significance 0 5 1
likely benign 5 0 9
benign 1 9 0

All variants with conflicting interpretations #

Total variants: 13
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NM_002291.3(LAMB1):c.1422C>G (p.Ser474=) rs780369106
NM_002291.3(LAMB1):c.1590A>C (p.Ser530=) rs139481973
NM_002291.3(LAMB1):c.1736G>A (p.Arg579Gln) rs115518856
NM_002291.3(LAMB1):c.1945G>A (p.Asp649Asn) rs142386151
NM_002291.3(LAMB1):c.2113G>C (p.Val705Leu) rs34150332
NM_002291.3(LAMB1):c.2542G>C (p.Ala848Pro) rs145746791
NM_002291.3(LAMB1):c.3012G>A (p.Thr1004=) rs113725211
NM_002291.3(LAMB1):c.3124G>A (p.Gly1042Ser) rs149204722
NM_002291.3(LAMB1):c.3650G>T (p.Arg1217Leu) rs80225385
NM_002291.3(LAMB1):c.4221C>T (p.Ser1407=) rs35082294
NM_002291.3(LAMB1):c.468T>C (p.Phe156=) rs149792171
NM_002291.3(LAMB1):c.476C>G (p.Thr159Ser) rs140146478
NM_002291.3(LAMB1):c.885C>T (p.His295=) rs148587474

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