ClinVar Miner

Variants in gene LZTR1 with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic) 		Variants with a confidence conflict
(e.g. benign vs likely benign) 		Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects) 		Variants with a clinically significant conflict
(e.g. benign vs pathogenic) 		Variants with any conflict
3178 411 0 129 51 0 41 205

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 66 18 1 0
likely pathogenic 66 0 32 0 0
uncertain significance 18 32 0 50 7
likely benign 1 0 50 0 63
benign 0 0 7 63 0

All variants with conflicting interpretations #

Total variants: 205
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_006767.4(LZTR1):c.2219+13C>T rs144005025 0.00972
NM_006767.4(LZTR1):c.1209C>T (p.Phe403=) rs145833752 0.00550
NM_006767.4(LZTR1):c.201-8C>T rs183476594 0.00520
NM_006767.4(LZTR1):c.2007C>T (p.Ile669=) rs138664443 0.00386
NM_006767.4(LZTR1):c.2373C>T (p.His791=) rs148993324 0.00299
NM_006767.4(LZTR1):c.2187C>T (p.Tyr729=) rs117346988 0.00222
NM_006767.4(LZTR1):c.741C>T (p.Ser247=) rs114458679 0.00183
NM_006767.4(LZTR1):c.1530C>T (p.His510=) rs190714197 0.00155
NM_006767.4(LZTR1):c.666C>T (p.Gly222=) rs35767542 0.00122
NM_006767.4(LZTR1):c.1395G>A (p.Ala465=) rs142418387 0.00108
NM_006767.4(LZTR1):c.-11G>A rs370616172 0.00097
NM_006767.4(LZTR1):c.1719C>T (p.Ser573=) rs150897932 0.00097
NM_006767.4(LZTR1):c.906G>A (p.Ala302=) rs143128466 0.00090
NM_006767.4(LZTR1):c.1904C>T (p.Pro635Leu) rs148677674 0.00077
NM_006767.4(LZTR1):c.1990G>A (p.Ala664Thr) rs140874089 0.00072
NM_006767.4(LZTR1):c.453C>T (p.Asp151=) rs142421078 0.00069
NM_006767.4(LZTR1):c.1353+8C>G rs75959644 0.00065
NM_006767.4(LZTR1):c.543G>A (p.Thr181=) rs151294009 0.00063
NM_006767.4(LZTR1):c.1723G>A (p.Asp575Asn) rs139368531 0.00061
NM_006767.4(LZTR1):c.652-10C>A rs200169897 0.00049
NM_006767.4(LZTR1):c.2316C>T (p.Asn772=) rs140327903 0.00047
NM_006767.4(LZTR1):c.1531G>A (p.Val511Met) rs200062851 0.00046
NM_006767.4(LZTR1):c.2022C>T (p.Asp674=) rs145303406 0.00044
NM_006767.4(LZTR1):c.855C>T (p.Tyr285=) rs140612093 0.00043
NM_006767.4(LZTR1):c.2511C>T (p.Gly837=) rs202072955 0.00036
NM_006767.4(LZTR1):c.2190C>T (p.Gly730=) rs144092577 0.00034
NM_006767.4(LZTR1):c.1939A>G (p.Ile647Val) rs148916790 0.00025
NM_006767.4(LZTR1):c.1333G>A (p.Val445Met) rs201070853 0.00024
NM_006767.4(LZTR1):c.1412G>A (p.Arg471His) rs139031749 0.00021
NM_006767.4(LZTR1):c.2301C>T (p.Asn767=) rs112615858 0.00021
NM_006767.4(LZTR1):c.678A>T (p.Pro226=) rs200001328 0.00021
NM_006767.4(LZTR1):c.264-13G>A rs587777176 0.00017
NM_006767.4(LZTR1):c.945C>T (p.Asp315=) rs559942119 0.00016
NM_006767.4(LZTR1):c.1449+18C>G rs369921461 0.00014
NM_006767.4(LZTR1):c.2407-18G>A rs542841506 0.00014
NM_006767.4(LZTR1):c.488C>T (p.Thr163Met) rs200806641 0.00014
NM_006767.4(LZTR1):c.1563C>T (p.Phe521=) rs145974096 0.00012
NM_006767.4(LZTR1):c.264-14C>T rs199963374 0.00012
NM_006767.4(LZTR1):c.351C>T (p.Pro117=) rs202066345 0.00012
NM_006767.4(LZTR1):c.2205G>A (p.Pro735=) rs368690209 0.00011
NM_006767.4(LZTR1):c.263+7G>A rs185749722 0.00010
NM_006767.4(LZTR1):c.1377C>T (p.His459=) rs752985853 0.00009
NM_006767.4(LZTR1):c.1943-256C>T rs761685529 0.00009
NM_006767.4(LZTR1):c.2428C>T (p.Arg810Trp) rs776893978 0.00009
NM_006767.4(LZTR1):c.366G>A (p.Ser122=) rs367767120 0.00009
NM_006767.4(LZTR1):c.1548C>T (p.Ala516=) rs545065457 0.00008
NM_006767.4(LZTR1):c.369C>T (p.Ala123=) rs773126123 0.00008
NM_006767.4(LZTR1):c.1084C>T (p.Arg362Ter) rs189150283 0.00007
NM_006767.4(LZTR1):c.1354A>G (p.Lys452Glu) rs200296313 0.00006
NM_006767.4(LZTR1):c.1396C>T (p.Arg466Trp) rs550922200 0.00006
NM_006767.4(LZTR1):c.1397G>A (p.Arg466Gln) rs587777180 0.00006
NM_006767.4(LZTR1):c.2062C>T (p.Arg688Cys) rs587777178 0.00006
NM_006767.4(LZTR1):c.2232G>A (p.Ala744=) rs139261473 0.00006
NM_006767.4(LZTR1):c.2325+17G>A rs570834637 0.00006
NM_006767.4(LZTR1):c.372C>T (p.Val124=) rs371891909 0.00006
NM_006767.4(LZTR1):c.593+11G>A rs200649588 0.00006
NM_006767.4(LZTR1):c.1018C>T (p.Arg340Ter) rs149850248 0.00005
NM_006767.4(LZTR1):c.1354-4G>A rs747750987 0.00005
NM_006767.4(LZTR1):c.1416G>A (p.Arg472=) rs367740343 0.00005
NM_006767.4(LZTR1):c.1785+19G>A rs777075178 0.00005
NM_006767.4(LZTR1):c.2514C>T (p.Ala838=) rs772037780 0.00005
NM_006767.4(LZTR1):c.1019G>A (p.Arg340Gln) rs368589786 0.00004
NM_006767.4(LZTR1):c.1260+16G>A rs376876059 0.00004
NM_006767.4(LZTR1):c.1353+16C>T rs143592070 0.00004
NM_006767.4(LZTR1):c.1394C>T (p.Ala465Val) rs753757778 0.00004
NM_006767.4(LZTR1):c.1450-14C>T rs767640622 0.00004
NM_006767.4(LZTR1):c.1710C>T (p.Ile570=) rs779730131 0.00004
NM_006767.4(LZTR1):c.1943-4C>G rs368391573 0.00004
NM_006767.4(LZTR1):c.2220-6C>T rs751178858 0.00004
NM_006767.4(LZTR1):c.2247C>T (p.Tyr749=) rs779077819 0.00004
NM_006767.4(LZTR1):c.2274G>A (p.Ala758=) rs144870586 0.00004
NM_006767.4(LZTR1):c.2317G>A (p.Val773Met) rs199586863 0.00004
NM_006767.4(LZTR1):c.2355A>G (p.Ala785=) rs751681487 0.00004
NM_006767.4(LZTR1):c.400+10C>T rs375186405 0.00004
NM_006767.4(LZTR1):c.651+9C>T rs754627103 0.00004
NM_006767.4(LZTR1):c.1402C>T (p.Arg468Cys) rs374741798 0.00003
NM_006767.4(LZTR1):c.842C>T (p.Pro281Leu) rs1390048261 0.00003
NM_006767.4(LZTR1):c.1615+4C>T rs551144605 0.00002
NM_006767.4(LZTR1):c.1749C>T (p.Cys583=) rs758399311 0.00002
NM_006767.4(LZTR1):c.1794C>A (p.Cys598Ter) rs982944299 0.00002
NM_006767.4(LZTR1):c.2265G>T (p.Arg755=) rs370009707 0.00002
NM_006767.4(LZTR1):c.2326-6T>C rs199965510 0.00002
NM_006767.4(LZTR1):c.2463dup (p.Asp822fs) rs781251567 0.00002
NM_006767.4(LZTR1):c.264-9G>T rs377233316 0.00002
NM_006767.4(LZTR1):c.353G>A (p.Arg118His) rs769001939 0.00002
NM_006767.4(LZTR1):c.1048C>T (p.Leu350=) rs199565862 0.00001
NM_006767.4(LZTR1):c.1149+3A>G rs542715642 0.00001
NM_006767.4(LZTR1):c.1251C>G (p.Tyr417Ter) rs1924657431 0.00001
NM_006767.4(LZTR1):c.1260+11T>A rs1298556569 0.00001
NM_006767.4(LZTR1):c.1261-2A>G rs759240190 0.00001
NM_006767.4(LZTR1):c.1330G>A (p.Asp444Asn) rs775051211 0.00001
NM_006767.4(LZTR1):c.1729C>T (p.Gln577Ter) rs1390034681 0.00001
NM_006767.4(LZTR1):c.1733_1734del (p.Asn578fs) rs1460026299 0.00001
NM_006767.4(LZTR1):c.1785+1G>A rs145594158 0.00001
NM_006767.4(LZTR1):c.2070-8G>T rs768003361 0.00001
NM_006767.4(LZTR1):c.2309T>C (p.Val770Ala) rs752880731 0.00001
NM_006767.4(LZTR1):c.2310G>A (p.Val770=) rs1226268646 0.00001
NM_006767.4(LZTR1):c.2407-2A>G rs1158550690 0.00001
NM_006767.4(LZTR1):c.2462T>C (p.Ile821Thr) rs1275511136 0.00001
NM_006767.4(LZTR1):c.263+1G>A rs761241914 0.00001
NM_006767.4(LZTR1):c.365C>T (p.Ser122Leu) rs587777177 0.00001
NM_006767.4(LZTR1):c.401-2A>G rs1222197005 0.00001
NM_006767.4(LZTR1):c.509G>A (p.Arg170Gln) rs781431741 0.00001
NM_006767.4(LZTR1):c.522T>G (p.Ala174=) rs745514794 0.00001
NM_006767.4(LZTR1):c.594-2A>G rs1374011263 0.00001
NM_006767.4(LZTR1):c.651+1G>T rs1450044732 0.00001
NM_006767.4(LZTR1):c.671dup (p.Ser227fs) rs1351226319 0.00001
NM_006767.4(LZTR1):c.848G>A (p.Arg283Gln) rs1223430276 0.00001
NM_006767.4(LZTR1):c.850C>T (p.Arg284Cys) rs797045165 0.00001
NM_006767.4(LZTR1):c.955C>T (p.Gln319Ter) rs1924617179 0.00001
NM_006767.4(LZTR1):c.993+1G>A rs770368435 0.00001
NM_006767.4(LZTR1):c.994-7T>G rs778889665 0.00001
NM_006767.4(LZTR1):c.1005_1012del (p.Glu336fs) rs753474547
NM_006767.4(LZTR1):c.1033G>T (p.Glu345Ter) rs761956867
NM_006767.4(LZTR1):c.1149+1G>A rs767191322
NM_006767.4(LZTR1):c.1199T>C (p.Met400Thr)
NM_006767.4(LZTR1):c.1214G>C (p.Gly405Ala)
NM_006767.4(LZTR1):c.1234C>T (p.Arg412Cys) rs747430075
NM_006767.4(LZTR1):c.1235G>A (p.Arg412His) rs935736801
NM_006767.4(LZTR1):c.1243G>T (p.Glu415Ter)
NM_006767.4(LZTR1):c.1250A>C (p.Tyr417Ser) rs1057524046
NM_006767.4(LZTR1):c.1314G>A (p.Glu438=)
NM_006767.4(LZTR1):c.1317_1323dup (p.Phe442fs) rs1131691862
NM_006767.4(LZTR1):c.1339T>G (p.Phe447Val) rs1312334046
NM_006767.4(LZTR1):c.1353+1G>T
NM_006767.4(LZTR1):c.1354-6G>C
NM_006767.4(LZTR1):c.1373dup (p.His459fs) rs1924703709
NM_006767.4(LZTR1):c.1447C>T (p.Gln483Ter) rs752547717
NM_006767.4(LZTR1):c.1449+9C>G rs756813850
NM_006767.4(LZTR1):c.1449G>A (p.Gln483=)
NM_006767.4(LZTR1):c.150_151del (p.Val51fs) rs1194536394
NM_006767.4(LZTR1):c.1590C>T (p.Thr530=)
NM_006767.4(LZTR1):c.1602A>G (p.Lys534=) rs1230203913
NM_006767.4(LZTR1):c.1605C>A (p.Tyr535Ter) rs753347937
NM_006767.4(LZTR1):c.1616-4del
NM_006767.4(LZTR1):c.1620T>C (p.His540=) rs141610191
NM_006767.4(LZTR1):c.1687G>C (p.Glu563Gln) rs1374240053
NM_006767.4(LZTR1):c.1698C>A (p.Cys566Ter)
NM_006767.4(LZTR1):c.1700G>A (p.Arg567His) rs372417941
NM_006767.4(LZTR1):c.1702C>T (p.Gln568Ter)
NM_006767.4(LZTR1):c.1785+13_1785+33dup
NM_006767.4(LZTR1):c.1785+4T>G rs1924762620
NM_006767.4(LZTR1):c.1870C>T (p.Leu624=)
NM_006767.4(LZTR1):c.1887_1888insAG (p.Arg630fs) rs1924776706
NM_006767.4(LZTR1):c.1901A>C (p.Gln634Pro) rs770312150
NM_006767.4(LZTR1):c.1941T>C (p.Ile647=)
NM_006767.4(LZTR1):c.1992G>A (p.Ala664=)
NM_006767.4(LZTR1):c.2070-15G>A rs1601722962
NM_006767.4(LZTR1):c.2090G>A (p.Arg697Gln) rs370638947
NM_006767.4(LZTR1):c.209A>G (p.Lys70Arg)
NM_006767.4(LZTR1):c.2103C>G (p.Pro701=) rs139080986
NM_006767.4(LZTR1):c.2103C>T (p.Pro701=) rs139080986
NM_006767.4(LZTR1):c.2113C>T (p.Gln705Ter) rs778396468
NM_006767.4(LZTR1):c.2127dup (p.Ile710fs)
NM_006767.4(LZTR1):c.2303dup (p.Thr769fs) rs1231204217
NM_006767.4(LZTR1):c.2326-10G>A rs778909787
NM_006767.4(LZTR1):c.2326-11T>G rs1421950903
NM_006767.4(LZTR1):c.2329del (p.Leu777fs)
NM_006767.4(LZTR1):c.2347dup (p.Thr783fs)
NM_006767.4(LZTR1):c.234T>C (p.Asp78=)
NM_006767.4(LZTR1):c.2404_2405delinsTTGG (p.Lys802fs) rs1601723893
NM_006767.4(LZTR1):c.2412dup (p.Lys805fs) rs1924895839
NM_006767.4(LZTR1):c.2443C>T (p.Gln815Ter)
NM_006767.4(LZTR1):c.263+7_263+10del rs765081424
NM_006767.4(LZTR1):c.273G>A (p.Met91Ile) rs1924362561
NM_006767.4(LZTR1):c.320+13G>A rs188924002
NM_006767.4(LZTR1):c.320+13G>C
NM_006767.4(LZTR1):c.321-2del
NM_006767.4(LZTR1):c.321-4C>T
NM_006767.4(LZTR1):c.347C>T (p.Ala116Val)
NM_006767.4(LZTR1):c.352del (p.Arg118fs) rs1486960809
NM_006767.4(LZTR1):c.352dup (p.Arg118fs) rs1486960809
NM_006767.4(LZTR1):c.370GTC[1] (p.Val125del) rs755783378
NM_006767.4(LZTR1):c.384C>T (p.Ser128=)
NM_006767.4(LZTR1):c.406T>C (p.Tyr136His) rs1601717299
NM_006767.4(LZTR1):c.438del (p.Lys147fs) rs1555927613
NM_006767.4(LZTR1):c.509+6A>G rs1024251271
NM_006767.4(LZTR1):c.509G>T (p.Arg170Leu) rs781431741
NM_006767.4(LZTR1):c.594-3C>G
NM_006767.4(LZTR1):c.604_605del (p.Met202fs)
NM_006767.4(LZTR1):c.628dup (p.Arg210fs) rs1457594219
NM_006767.4(LZTR1):c.651+10_651+46del rs541944601
NM_006767.4(LZTR1):c.651+3G>A
NM_006767.4(LZTR1):c.651+5G>A rs766055427
NM_006767.4(LZTR1):c.652-1G>C
NM_006767.4(LZTR1):c.652-2A>C
NM_006767.4(LZTR1):c.677C>T (p.Pro226Leu) rs2147964011
NM_006767.4(LZTR1):c.677del (p.Pro226fs)
NM_006767.4(LZTR1):c.677dup (p.Ser227fs) rs777054968
NM_006767.4(LZTR1):c.678A>G (p.Pro226=) rs200001328
NM_006767.4(LZTR1):c.686G>C (p.Cys229Ser) rs2147964025
NM_006767.4(LZTR1):c.736C>T (p.Gln246Ter)
NM_006767.4(LZTR1):c.742G>A (p.Gly248Arg) rs869320686
NM_006767.4(LZTR1):c.774del (p.Phe258fs) rs780267761
NM_006767.4(LZTR1):c.791+1G>A rs148031742
NM_006767.4(LZTR1):c.791+1G>C rs148031742
NM_006767.4(LZTR1):c.791+1G>T
NM_006767.4(LZTR1):c.794G>A (p.Trp265Ter)
NM_006767.4(LZTR1):c.842del (p.Pro281fs) rs1419091884
NM_006767.4(LZTR1):c.851G>A (p.Arg284His) rs768361273
NM_006767.4(LZTR1):c.890_891del (p.Tyr297fs) rs767445373
NM_006767.4(LZTR1):c.918G>A (p.Thr306=) rs367738742
NM_006767.4(LZTR1):c.955del (p.Gln319fs) rs1386054181
NM_006767.4(LZTR1):c.978_985del (p.Ser327fs)
NM_006767.4(LZTR1):c.993+1G>T rs770368435

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.