ClinVar Miner

Variants in gene MRE11 with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
1001 83 0 20 24 0 8 44

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 6 4 0 0
likely pathogenic 6 0 4 0 0
uncertain significance 4 4 0 23 7
likely benign 0 0 23 0 14
benign 0 0 7 14 0

All variants with conflicting interpretations #

Total variants: 44
Download table as spreadsheet
NM_005590.4(MRE11):c.120C>T (p.Leu40=) rs1805364
NM_005590.4(MRE11):c.1516G>T (p.Glu506Ter) rs587781384
NM_005590.4(MRE11):c.229G>T (p.Glu77Ter) rs779269083
NM_005591.3(MRE11):c.121G>A (p.Asp41Asn) rs116679717
NM_005591.3(MRE11):c.1275A>C (p.Thr425=) rs749712745
NM_005591.3(MRE11):c.1404T>C (p.Asp468=) rs368144567
NM_005591.3(MRE11):c.1462C>T (p.Arg488Cys) rs375261439
NM_005591.3(MRE11):c.1491C>T (p.Ile497=) rs199634245
NM_005591.3(MRE11):c.1501-4C>G rs377584386
NM_005591.3(MRE11):c.1643T>C (p.Ile548Thr) rs373522639
NM_005591.3(MRE11):c.1667A>G (p.Asn556Ser) rs144896235
NM_005591.3(MRE11):c.1727G>A (p.Arg576Gln) rs139461096
NM_005591.3(MRE11):c.1758G>A (p.Ser586=) rs766372720
NM_005591.3(MRE11):c.1780A>G (p.Arg594Gly) rs576878377
NM_005591.3(MRE11):c.1783+10G>C rs864622589
NM_005591.3(MRE11):c.1783+5G>C rs142082313
NM_005591.3(MRE11):c.1783+7A>G rs774520952
NM_005591.3(MRE11):c.1798G>C (p.Glu600Gln) rs145415033
NM_005591.3(MRE11):c.1811G>C (p.Arg604Pro) rs148637964
NM_005591.3(MRE11):c.1868-4C>A rs768257868
NM_005591.3(MRE11):c.1974C>T (p.Thr658=) rs772019392
NM_005591.3(MRE11):c.20+8C>A rs766581183
NM_005591.3(MRE11):c.2092A>G (p.Met698Val) rs1805362
NM_005591.3(MRE11):c.21-6_26del rs587780138
NM_005591.3(MRE11):c.315-4del rs35062043
NM_005591.3(MRE11):c.426C>T (p.Asp142=) rs3218740
NM_005591.3(MRE11):c.659+1G>A rs759130031
NM_005591.3(MRE11):c.771A>G (p.Glu257=) rs13447632
NM_005591.3(MRE11):c.777G>A (p.Gln259=) rs774144789
NM_005591.3(MRE11):c.77T>C (p.Met26Thr) rs372068015
NM_005591.3(MRE11):c.822T>C (p.Leu274=) rs137868143
NM_005591.3(MRE11):c.913C>T (p.Arg305Trp) rs372000848
NM_005591.3(MRE11):c.940C>T (p.Leu314=) rs368362407
NM_005591.3(MRE11):c.969A>G (p.Pro323=) rs13447633
NM_005591.4(MRE11):c.1112dup (p.Gly372fs) rs1591681273
NM_005591.4(MRE11):c.140C>T (p.Ala47Val) rs730880378
NM_005591.4(MRE11):c.1475C>A (p.Ala492Asp) rs61749249
NM_005591.4(MRE11):c.1480G>A (p.Glu494Lys) rs104895016
NM_005591.4(MRE11):c.1714C>T (p.Arg572Ter) rs137852761
NM_005591.4(MRE11):c.1960_1979dup (p.Lys661fs) rs587781442
NM_005591.4(MRE11):c.315-14dup rs35062043
NM_005591.4(MRE11):c.350A>G (p.Asn117Ser) rs137852760
NM_005591.4(MRE11):c.403-6G>A rs535801
NM_005591.4(MRE11):c.820_821del (p.Leu274fs) rs1565228898

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