ClinVar Miner

Variants in gene MRE11 with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
556 167 0 28 24 1 8 53

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign other
pathogenic 0 7 4 0 0 0
likely pathogenic 7 0 6 0 0 0
uncertain significance 4 6 0 23 7 1
likely benign 0 0 23 0 21 0
benign 0 0 7 21 0 0
other 0 0 1 0 0 0

All variants with conflicting interpretations #

Total variants: 53
Download table as spreadsheet
HGVS dbSNP
NM_005590.3(MRE11):c.1202A>G (p.His401Arg) rs146779325
NM_005590.3(MRE11):c.229G>T (p.Glu77Ter) rs779269083
NM_005591.3(MRE11):c.1002C>G (p.Ser334Arg) rs115244417
NM_005591.3(MRE11):c.1015A>T (p.Lys339Ter) rs984874083
NM_005591.3(MRE11):c.1090C>A (p.Arg364=) rs371077728
NM_005591.3(MRE11):c.120C>T (p.Leu40=) rs1805364
NM_005591.3(MRE11):c.121G>A (p.Asp41Asn) rs116679717
NM_005591.3(MRE11):c.1221A>C (p.Lys407Asn) rs587780135
NM_005591.3(MRE11):c.1222dupA (p.Thr408Asnfs) rs774440500
NM_005591.3(MRE11):c.1404T>C (p.Asp468=) rs368144567
NM_005591.3(MRE11):c.140C>T (p.Ala47Val) rs730880378
NM_005591.3(MRE11):c.1462C>T (p.Arg488Cys) rs375261439
NM_005591.3(MRE11):c.1475C>A (p.Ala492Asp) rs61749249
NM_005591.3(MRE11):c.1480G>A (p.Glu494Lys) rs104895016
NM_005591.3(MRE11):c.1491C>T (p.Ile497=) rs199634245
NM_005591.3(MRE11):c.1516G>T (p.Glu506Ter) rs587781384
NM_005591.3(MRE11):c.1714C>T (p.Arg572Ter) rs137852761
NM_005591.3(MRE11):c.1727G>A (p.Arg576Gln) rs139461096
NM_005591.3(MRE11):c.1758G>A (p.Ser586=) rs766372720
NM_005591.3(MRE11):c.1780A>G (p.Arg594Gly) rs576878377
NM_005591.3(MRE11):c.1783+5G>C rs142082313
NM_005591.3(MRE11):c.1783+7A>G rs774520952
NM_005591.3(MRE11):c.1798G>C (p.Glu600Gln) rs145415033
NM_005591.3(MRE11):c.1811G>C (p.Arg604Pro) rs148637964
NM_005591.3(MRE11):c.1868-4C>A rs768257868
NM_005591.3(MRE11):c.18A>T (p.Ala6=) rs758314845
NM_005591.3(MRE11):c.1960_1979dup20 (p.Lys661Thrfs) rs587781442
NM_005591.3(MRE11):c.1974C>T (p.Thr658=) rs772019392
NM_005591.3(MRE11):c.1994+10G>A rs1805366
NM_005591.3(MRE11):c.19C>T (p.Leu7Phe) rs73517551
NM_005591.3(MRE11):c.2007A>G (p.Thr669=) rs1554999945
NM_005591.3(MRE11):c.2070+2T>A rs786202801
NM_005591.3(MRE11):c.2071-53G>T rs13447742
NM_005591.3(MRE11):c.2092A>G (p.Met698Val) rs1805362
NM_005591.3(MRE11):c.21-6_26delATATAGTGATGA rs587780138
NM_005591.3(MRE11):c.2113A>G (p.Arg705Gly) rs755681342
NM_005591.3(MRE11):c.315-4delT rs35062043
NM_005591.3(MRE11):c.315-4dupT rs35062043
NM_005591.3(MRE11):c.350A>G (p.Asn117Ser) rs137852760
NM_005591.3(MRE11):c.37T>A (p.Phe13Ile) rs149101834
NM_005591.3(MRE11):c.403-6G>A rs535801
NM_005591.3(MRE11):c.426C>T (p.Asp142=) rs3218740
NM_005591.3(MRE11):c.469A>G (p.Met157Val) rs147771140
NM_005591.3(MRE11):c.534A>G (p.Leu178=) rs374635285
NM_005591.3(MRE11):c.659+1G>A rs759130031
NM_005591.3(MRE11):c.660-5T>G rs587781873
NM_005591.3(MRE11):c.771A>G (p.Glu257=) rs13447632
NM_005591.3(MRE11):c.77T>C (p.Met26Thr) rs372068015
NM_005591.3(MRE11):c.81G>A (p.Glu27=) rs190031653
NM_005591.3(MRE11):c.822T>C (p.Leu274=) rs137868143
NM_005591.3(MRE11):c.845+11T>C rs140145979
NM_005591.3(MRE11):c.913C>T (p.Arg305Trp) rs372000848
NM_005591.3(MRE11):c.969A>G (p.Pro323=) rs13447633

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