ClinVar Miner

Variants in gene PALB2 with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
2824 688 0 133 121 10 12 248

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor
pathogenic 0 63 3 0 0 10
likely pathogenic 63 0 10 0 0 0
uncertain significance 3 10 0 108 28 0
likely benign 0 0 108 0 70 0
benign 0 0 28 70 0 0
risk factor 10 0 0 0 0 0

All variants with conflicting interpretations #

Total variants: 248
Download table as spreadsheet
HGVS dbSNP
NM_024675.3(PALB2):c.-5G>T rs730881875
NM_024675.3(PALB2):c.1000T>G (p.Tyr334Asp) rs202241382
NM_024675.3(PALB2):c.1001A>G (p.Tyr334Cys) rs200620434
NM_024675.3(PALB2):c.1010T>C (p.Leu337Ser) rs45494092
NM_024675.3(PALB2):c.1027C>T (p.Gln343Ter) rs180177097
NM_024675.3(PALB2):c.1042C>A (p.Gln348Lys) rs375699023
NM_024675.3(PALB2):c.1054G>C (p.Glu352Gln) rs201035780
NM_024675.3(PALB2):c.1103A>G (p.Asn368Ser) rs1060502799
NM_024675.3(PALB2):c.1108C>T (p.Gln370Ter) rs587776411
NM_024675.3(PALB2):c.1110G>A (p.Gln370=) rs756002989
NM_024675.3(PALB2):c.1165C>G (p.Leu389Val) rs1555461427
NM_024675.3(PALB2):c.1189A>T (p.Thr397Ser) rs367578415
NM_024675.3(PALB2):c.1192G>A (p.Val398Met) rs769097541
NM_024675.3(PALB2):c.1194G>A (p.Val398=) rs61755173
NM_024675.3(PALB2):c.11C>T (p.Pro4Leu) rs45619737
NM_024675.3(PALB2):c.1227T>C (p.Tyr409=) rs1555461386
NM_024675.3(PALB2):c.1273G>A (p.Val425Met) rs576081828
NM_024675.3(PALB2):c.1285A>G (p.Ile429Val) rs1555461360
NM_024675.3(PALB2):c.1288C>T (p.Gln430Ter) rs1555461358
NM_024675.3(PALB2):c.12T>C (p.Pro4=) rs567706422
NM_024675.3(PALB2):c.1317G>A (p.Gly439=) rs515726066
NM_024675.3(PALB2):c.1366G>T (p.Glu456Ter) rs1060502785
NM_024675.3(PALB2):c.1376A>G (p.Asp459Gly) rs1031787378
NM_024675.3(PALB2):c.1380A>G (p.Gln460=) rs372641262
NM_024675.3(PALB2):c.13C>T (p.Pro5Ser) rs377085677
NM_024675.3(PALB2):c.1400G>A (p.Gly467Asp) rs730881906
NM_024675.3(PALB2):c.1419A>C (p.Pro473=) rs62625275
NM_024675.3(PALB2):c.1431C>T (p.Thr477=) rs515726068
NM_024675.3(PALB2):c.1470C>T (p.Pro490=) rs45612837
NM_024675.3(PALB2):c.1478C>T (p.Pro493Leu) rs770965402
NM_024675.3(PALB2):c.1485del (p.Asp496fs) rs1555461256
NM_024675.3(PALB2):c.1490del (p.Asn497fs) rs1555461253
NM_024675.3(PALB2):c.1492G>T (p.Asp498Tyr) rs75023630
NM_024675.3(PALB2):c.149A>C (p.Lys50Thr) rs763598472
NM_024675.3(PALB2):c.1506G>C (p.Lys502Asn) rs371142570
NM_024675.3(PALB2):c.1564C>T (p.Pro522Ser) rs373876101
NM_024675.3(PALB2):c.1572A>G (p.Ser524=) rs45472400
NM_024675.3(PALB2):c.1592del (p.Leu531fs) rs180177102
NM_024675.3(PALB2):c.1606C>T (p.Leu536=) rs151162255
NM_024675.3(PALB2):c.1610C>T (p.Ser537Leu) rs142103232
NM_024675.3(PALB2):c.161A>G (p.Glu54Gly) rs730881898
NM_024675.3(PALB2):c.1623G>A (p.Arg541=) rs745665968
NM_024675.3(PALB2):c.1641C>T (p.Thr547=) rs564514783
NM_024675.3(PALB2):c.1646A>G (p.His549Arg) rs1597095334
NM_024675.3(PALB2):c.1653T>A (p.Tyr551Ter) rs118203997
NM_024675.3(PALB2):c.1676A>G (p.Gln559Arg) rs152451
NM_024675.3(PALB2):c.1697G>A (p.Arg566His) rs144617793
NM_024675.3(PALB2):c.1699C>T (p.His567Tyr) rs370422990
NM_024675.3(PALB2):c.1756G>A (p.Asp586Asn) rs587781954
NM_024675.3(PALB2):c.1794G>A (p.Leu598=) rs182494675
NM_024675.3(PALB2):c.1810C>T (p.Leu604=) rs144015319
NM_024675.3(PALB2):c.1881G>A (p.Val627=) rs139362268
NM_024675.3(PALB2):c.1881G>T (p.Val627=) rs139362268
NM_024675.3(PALB2):c.1923A>G (p.Lys641=) rs775283927
NM_024675.3(PALB2):c.1924del (p.Met642fs) rs730881865
NM_024675.3(PALB2):c.1941T>C (p.His647=) rs745467835
NM_024675.3(PALB2):c.1947dup (p.Glu650fs) rs515726075
NM_024675.3(PALB2):c.1955G>A (p.Ser652Asn) rs587781818
NM_024675.3(PALB2):c.195G>A (p.Pro65=) rs751176316
NM_024675.3(PALB2):c.196C>T (p.Gln66Ter) rs180177083
NM_024675.3(PALB2):c.2027T>C (p.Ile676Thr) rs200875161
NM_024675.3(PALB2):c.2066C>T (p.Ser689Leu) rs749602688
NM_024675.3(PALB2):c.2067G>A (p.Ser689=) rs371149159
NM_024675.3(PALB2):c.2100A>T (p.Ser700=) rs757145884
NM_024675.3(PALB2):c.212-2A>C rs730881879
NM_024675.3(PALB2):c.212-2A>G rs730881879
NM_024675.3(PALB2):c.2130G>A (p.Thr710=) rs774049060
NM_024675.3(PALB2):c.2192T>G (p.Leu731Ter) rs1567217898
NM_024675.3(PALB2):c.2204C>T (p.Pro735Leu) rs199743500
NM_024675.3(PALB2):c.2228A>G (p.Tyr743Cys) rs141749524
NM_024675.3(PALB2):c.2230G>A (p.Glu744Lys) rs62625278
NM_024675.3(PALB2):c.223A>T (p.Lys75Ter) rs1555461875
NM_024675.3(PALB2):c.2244A>G (p.Thr748=) rs750048627
NM_024675.3(PALB2):c.2256A>G (p.Gly752=) rs147120218
NM_024675.3(PALB2):c.226del (p.Ile76fs) rs587782443
NM_024675.3(PALB2):c.2277A>G (p.Gln759=) rs786202524
NM_024675.3(PALB2):c.2288_2291del (p.His762_Leu763insTer) rs876659571
NM_024675.3(PALB2):c.2289G>C (p.Leu763Phe) rs373478248
NM_024675.3(PALB2):c.2323C>T (p.Gln775Ter) rs180177111
NM_024675.3(PALB2):c.2329G>A (p.Asp777Asn) rs148026749
NM_024675.3(PALB2):c.232G>A (p.Val78Ile) rs515726085
NM_024675.3(PALB2):c.2336C>G (p.Ser779Ter) rs764509489
NM_024675.3(PALB2):c.2360C>T (p.Thr787Ile) rs201042302
NM_024675.3(PALB2):c.2365C>T (p.Leu789=) rs145805054
NM_024675.3(PALB2):c.2368C>T (p.Gln790Ter) rs886039480
NM_024675.3(PALB2):c.2386G>T (p.Gly796Ter) rs180177112
NM_024675.3(PALB2):c.2391del (p.Gln797fs) rs1555460360
NM_024675.3(PALB2):c.2417C>T (p.Pro806Leu) rs45464991
NM_024675.3(PALB2):c.2418G>A (p.Pro806=) rs577076372
NM_024675.3(PALB2):c.2418G>T (p.Pro806=) rs577076372
NM_024675.3(PALB2):c.243G>A (p.Lys81=) rs1060502775
NM_024675.3(PALB2):c.2442G>A (p.Glu814=) rs140776736
NM_024675.3(PALB2):c.2456_2463del (p.Lys819fs) rs1555460325
NM_024675.3(PALB2):c.2474G>C (p.Arg825Thr) rs146218439
NM_024675.3(PALB2):c.2484C>T (p.Cys828=) rs875989798
NM_024675.3(PALB2):c.2505C>T (p.Ser835=) rs756502783
NM_024675.3(PALB2):c.2509G>A (p.Glu837Lys) rs587778587
NM_024675.3(PALB2):c.2514+3dup rs587781602
NM_024675.3(PALB2):c.2515-1G>C rs587776417
NM_024675.3(PALB2):c.2559C>T (p.Gly853=) rs180177115
NM_024675.3(PALB2):c.2561A>G (p.Asn854Ser) rs146455175
NM_024675.3(PALB2):c.2566C>T (p.Gln856Ter) rs770996884
NM_024675.3(PALB2):c.2571G>A (p.Leu857=) rs587780821
NM_024675.3(PALB2):c.2576C>A (p.Ser859Ter) rs1057517539
NM_024675.3(PALB2):c.2586+10A>G rs373321719
NM_024675.3(PALB2):c.2590C>T (p.Pro864Ser) rs45568339
NM_024675.3(PALB2):c.2607C>A (p.Ser869=) rs45542234
NM_024675.3(PALB2):c.2607C>T (p.Ser869=) rs45542234
NM_024675.3(PALB2):c.2608G>A (p.Val870Ile) rs376641234
NM_024675.3(PALB2):c.2616G>T (p.Val872=) rs1567215519
NM_024675.3(PALB2):c.2673C>T (p.Cys891=) rs78179744
NM_024675.3(PALB2):c.2674G>A (p.Glu892Lys) rs45476495
NM_024675.3(PALB2):c.2677G>T (p.Asp893Tyr) rs765077104
NM_024675.3(PALB2):c.2725C>G (p.Leu909Val) rs1060502739
NM_024675.3(PALB2):c.2742C>T (p.Phe914=) rs115759702
NM_024675.3(PALB2):c.2747_2748+4del rs786203892
NM_024675.3(PALB2):c.2748+1G>T rs753153576
NM_024675.3(PALB2):c.2749-18C>T rs182194007
NM_024675.3(PALB2):c.2752C>T (p.Pro918Ser) rs515726094
NM_024675.3(PALB2):c.2773G>C (p.Val925Leu) rs180177125
NM_024675.3(PALB2):c.2784G>A (p.Val928=) rs763411245
NM_024675.3(PALB2):c.2794G>A (p.Val932Met) rs45624036
NM_024675.3(PALB2):c.2834+18A>T rs114491776
NM_024675.3(PALB2):c.2834+1G>T rs587776419
NM_024675.3(PALB2):c.2835-1G>C rs515726099
NM_024675.3(PALB2):c.2851T>C (p.Ser951Pro) rs149522412
NM_024675.3(PALB2):c.2852C>T (p.Ser951Phe) rs587782889
NM_024675.3(PALB2):c.2881C>T (p.Leu961=) rs61755166
NM_024675.3(PALB2):c.2903C>G (p.Ala968Gly) rs369132015
NM_024675.3(PALB2):c.292A>G (p.Ile98Val) rs587782831
NM_024675.3(PALB2):c.2959_2966dup (p.Glu990fs) rs875989792
NM_024675.3(PALB2):c.2962C>T (p.Gln988Ter) rs118203999
NM_024675.3(PALB2):c.2964A>G (p.Gln988=) rs777244673
NM_024675.3(PALB2):c.2974_2975dup (p.Met992fs) rs1555459520
NM_024675.3(PALB2):c.2982dup (p.Ala995fs) rs180177127
NM_024675.3(PALB2):c.298C>T (p.Leu100Phe) rs61756147
NM_024675.3(PALB2):c.2993G>A (p.Gly998Glu) rs45551636
NM_024675.3(PALB2):c.2996+9del rs769414858
NM_024675.3(PALB2):c.2997-9T>C rs765733708
NM_024675.3(PALB2):c.3017del (p.Phe1005_Leu1006insTer) rs886039683
NM_024675.3(PALB2):c.3053A>C (p.Glu1018Ala) rs1567212910
NM_024675.3(PALB2):c.3054G>C (p.Glu1018Asp) rs183489969
NM_024675.3(PALB2):c.3103A>G (p.Ile1035Val) rs863224783
NM_024675.3(PALB2):c.3113+5G>C rs876659463
NM_024675.3(PALB2):c.3113G>A (p.Trp1038Ter) rs180177132
NM_024675.3(PALB2):c.3114-5C>T rs753307725
NM_024675.3(PALB2):c.3116del (p.Asn1039fs) rs180177133
NM_024675.3(PALB2):c.3130C>T (p.Gln1044Ter) rs766394024
NM_024675.3(PALB2):c.3201+1G>C rs587776423
NM_024675.3(PALB2):c.3202-1G>A rs515726111
NM_024675.3(PALB2):c.3202-8G>A rs367979106
NM_024675.3(PALB2):c.3202-8G>T rs367979106
NM_024675.3(PALB2):c.3249G>C (p.Glu1083Asp) rs147045425
NM_024675.3(PALB2):c.3251C>T (p.Ser1084Leu) rs62625271
NM_024675.3(PALB2):c.3256C>G (p.Arg1086Gly) rs587776527
NM_024675.3(PALB2):c.3256C>T (p.Arg1086Ter) rs587776527
NM_024675.3(PALB2):c.3256del (p.Arg1086fs) rs1057517600
NM_024675.3(PALB2):c.3297G>C (p.Thr1099=) rs45565738
NM_024675.3(PALB2):c.3300T>G (p.Thr1100=) rs45516100
NM_024675.3(PALB2):c.3307G>A (p.Val1103Met) rs201657283
NM_024675.3(PALB2):c.3324C>G (p.Tyr1108Ter) rs1218512317
NM_024675.3(PALB2):c.3342G>C (p.Gln1114His) rs1567206753
NM_024675.3(PALB2):c.3350+4A>G rs180177136
NM_024675.3(PALB2):c.3362del (p.Gly1121fs) rs515726117
NM_024675.3(PALB2):c.3425del (p.Leu1142fs) rs1057517563
NM_024675.3(PALB2):c.344G>T (p.Gly115Val) rs145598272
NM_024675.3(PALB2):c.3492G>A (p.Trp1164Ter) rs587782217
NM_024675.3(PALB2):c.3495G>A (p.Ser1165=) rs45439097
NM_024675.3(PALB2):c.3500C>T (p.Thr1167Ile) rs1308784980
NM_024675.3(PALB2):c.3508C>T (p.His1170Tyr) rs200283306
NM_024675.3(PALB2):c.3549C>G (p.Tyr1183Ter) rs118203998
NM_024675.3(PALB2):c.400G>A (p.Asp134Asn) rs139555085
NM_024675.3(PALB2):c.444del (p.Lys149fs) rs1555461796
NM_024675.3(PALB2):c.459G>A (p.Arg153=) rs876658633
NM_024675.3(PALB2):c.475G>T (p.Glu159Ter) rs1555461788
NM_024675.3(PALB2):c.48+5C>T rs1555462488
NM_024675.3(PALB2):c.48+7G>C rs190626072
NM_024675.3(PALB2):c.48G>A (p.Lys16=) rs587776405
NM_024675.3(PALB2):c.49-2A>T rs786203245
NM_024675.3(PALB2):c.495C>T (p.Gly165=) rs200937538
NM_024675.3(PALB2):c.503C>A (p.Ser168Ter) rs515726122
NM_024675.3(PALB2):c.508A>G (p.Arg170Gly) rs864622622
NM_024675.3(PALB2):c.53A>G (p.Lys18Arg) rs138789658
NM_024675.3(PALB2):c.601dup (p.Ser201fs) rs886041220
NM_024675.3(PALB2):c.629C>T (p.Pro210Leu) rs57605939
NM_024675.3(PALB2):c.62T>G (p.Leu21Ter) rs769240800
NM_024675.3(PALB2):c.661G>A (p.Val221Ile) rs1060502773
NM_024675.3(PALB2):c.718C>A (p.Pro240Thr) rs757567654
NM_024675.3(PALB2):c.721A>G (p.Asn241Asp) rs113217267
NM_024675.3(PALB2):c.734C>T (p.Ala245Val) rs571063157
NM_024675.3(PALB2):c.758dup (p.Ser254fs) rs515726126
NM_024675.3(PALB2):c.759del (p.Ser254fs) rs1060499830
NM_024675.3(PALB2):c.765T>C (p.Asp255=) rs45465299
NM_024675.3(PALB2):c.769G>A (p.Gly257Ser) rs587780824
NM_024675.3(PALB2):c.820dup (p.Thr274fs) rs1555461611
NM_024675.3(PALB2):c.829G>A (p.Asp277Asn) rs778309339
NM_024675.3(PALB2):c.850A>G (p.Thr284Ala) rs1555461584
NM_024675.3(PALB2):c.860dup (p.Ser288fs) rs864622301
NM_024675.3(PALB2):c.892G>A (p.Val298Ile) rs1060502765
NM_024675.3(PALB2):c.899C>T (p.Thr300Ile) rs528541334
NM_024675.3(PALB2):c.908T>C (p.Leu303Pro) rs774057025
NM_024675.3(PALB2):c.909C>T (p.Leu303=) rs145788619
NM_024675.3(PALB2):c.925A>G (p.Ile309Val) rs3809683
NM_024675.3(PALB2):c.928A>G (p.Ser310Gly) rs45561331
NM_024675.3(PALB2):c.940C>T (p.Gln314Ter) rs786203821
NM_024675.3(PALB2):c.94C>G (p.Leu32Val) rs151316635
NM_024675.3(PALB2):c.950C>T (p.Thr317Ile) rs45548638
NM_024675.3(PALB2):c.999C>T (p.Thr333=) rs180177096
NM_024675.4(PALB2):c.1042C>T (p.Gln348Ter) rs375699023
NM_024675.4(PALB2):c.1250C>A (p.Ser417Tyr) rs45510998
NM_024675.4(PALB2):c.1379A>G (p.Gln460Arg) rs749494645
NM_024675.4(PALB2):c.1424dup (p.Arg476fs) rs1555461294
NM_024675.4(PALB2):c.1540G>A (p.Gly514Arg) rs756778249
NM_024675.4(PALB2):c.1544A>G (p.Lys515Arg) rs515726072
NM_024675.4(PALB2):c.172_175del (p.Gln60fs) rs180177143
NM_024675.4(PALB2):c.1861C>A (p.Pro621Thr) rs756116550
NM_024675.4(PALB2):c.1917G>T (p.Glu639Asp) rs1597090787
NM_024675.4(PALB2):c.194C>T (p.Pro65Leu) rs62625272
NM_024675.4(PALB2):c.2014G>C (p.Glu672Gln) rs45532440
NM_024675.4(PALB2):c.2055A>G (p.Lys685=) rs1597090304
NM_024675.4(PALB2):c.212-10del rs766487430
NM_024675.4(PALB2):c.2135C>T (p.Ala712Val) rs141458731
NM_024675.4(PALB2):c.2218C>T (p.Gln740Ter) rs1555460445
NM_024675.4(PALB2):c.2258G>A (p.Arg753Gln) rs587778586
NM_024675.4(PALB2):c.228_229del (p.Ile76fs) rs1555461870
NM_024675.4(PALB2):c.2379C>T (p.Gly793=) rs377626805
NM_024675.4(PALB2):c.23C>T (p.Pro8Leu) rs150390726
NM_024675.4(PALB2):c.2411_2412del (p.Ser804fs) rs747148023
NM_024675.4(PALB2):c.2438T>C (p.Ile813Thr) rs763191051
NM_024675.4(PALB2):c.2506G>A (p.Val836Ile) rs536644825
NM_024675.4(PALB2):c.2587-1G>C rs761214886
NM_024675.4(PALB2):c.2816T>G (p.Leu939Trp) rs45478192
NM_024675.4(PALB2):c.2834+4T>C rs982643702
NM_024675.4(PALB2):c.2961A>G (p.Gln987=) rs1555459530
NM_024675.4(PALB2):c.2997-1G>A rs754465466
NM_024675.4(PALB2):c.3049G>A (p.Ala1017Thr)
NM_024675.4(PALB2):c.3056T>C (p.Val1019Ala) rs376619846
NM_024675.4(PALB2):c.3257G>A (p.Arg1086Gln) rs146377793
NM_024675.4(PALB2):c.3271C>T (p.Gln1091Ter) rs864622138
NM_024675.4(PALB2):c.3350+5G>A rs587782566
NM_024675.4(PALB2):c.3350G>A (p.Arg1117Lys) rs876659859
NM_024675.4(PALB2):c.3426_3429del (p.Leu1142fs) rs587776424
NM_024675.4(PALB2):c.3428T>A (p.Leu1143His) rs62625284
NM_024675.4(PALB2):c.3504C>G (p.Asp1168Glu)
NM_024675.4(PALB2):c.3507_3508del (p.His1170fs) rs587776428
NM_024675.4(PALB2):c.656A>G (p.Asp219Gly) rs45594034
NM_024675.4(PALB2):c.93dup (p.Leu32fs) rs864622498
PALB2:c.2515-1G>T rs587776417

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