ClinVar Miner

Variants in gene PRDM16 with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic) 		Variants with a confidence conflict
(e.g. benign vs likely benign) 		Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects) 		Variants with a clinically significant conflict
(e.g. benign vs pathogenic) 		Variants with any conflict
1066 102 0 58 21 0 2 77

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic uncertain significance likely benign benign
pathogenic 0 2 0 0
uncertain significance 2 0 20 5
likely benign 0 20 0 58
benign 0 5 58 0

All variants with conflicting interpretations #

Total variants: 77
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_022114.4(PRDM16):c.1898C>T (p.Pro633Leu) rs2493292 0.14386
NM_022114.4(PRDM16):c.1212G>A (p.Thr404=) rs139129844 0.00438
NM_022114.4(PRDM16):c.3130C>T (p.Leu1044Phe) rs187400273 0.00386
NM_022114.4(PRDM16):c.100G>A (p.Ala34Thr) rs187194973 0.00252
NM_022114.4(PRDM16):c.2506G>A (p.Gly836Ser) rs114204766 0.00168
NM_022114.4(PRDM16):c.1188T>C (p.Cys396=) rs201309284 0.00167
NM_022114.4(PRDM16):c.2452G>A (p.Gly818Ser) rs201904226 0.00160
NM_022114.4(PRDM16):c.1684G>A (p.Val562Ile) rs150395260 0.00159
NM_022114.4(PRDM16):c.201G>A (p.Pro67=) rs199614349 0.00153
NM_022114.4(PRDM16):c.3102C>T (p.Asn1034=) rs199853370 0.00144
NM_022114.4(PRDM16):c.3687T>C (p.Ala1229=) rs188634763 0.00137
NM_022114.4(PRDM16):c.49G>A (p.Val17Ile) rs183153140 0.00137
NM_022114.4(PRDM16):c.1426C>T (p.Pro476Ser) rs188908415 0.00131
NM_022114.4(PRDM16):c.2290G>A (p.Val764Met) rs149333409 0.00117
NM_022114.4(PRDM16):c.3621A>T (p.Glu1207Asp) rs199972068 0.00117
NM_022114.4(PRDM16):c.2130G>A (p.Gly710=) rs193118666 0.00112
NM_022114.4(PRDM16):c.573+17A>G rs370287328 0.00091
NM_022114.4(PRDM16):c.429C>T (p.Cys143=) rs150097149 0.00084
NM_022114.4(PRDM16):c.2634C>T (p.Pro878=) rs201338158 0.00065
NM_022114.4(PRDM16):c.2406G>A (p.Pro802=) rs368750536 0.00063
NM_022114.4(PRDM16):c.2786C>A (p.Pro929His) rs145632008 0.00063
NM_022114.4(PRDM16):c.934G>A (p.Asp312Asn) rs191798831 0.00060
NM_022114.4(PRDM16):c.1599G>A (p.Ser533=) rs373205864 0.00059
NM_022114.4(PRDM16):c.2603+6C>T rs374549827 0.00058
NM_022114.4(PRDM16):c.38-14G>A rs368409902 0.00058
NM_022114.4(PRDM16):c.2449G>A (p.Gly817Ser) rs375308440 0.00057
NM_022114.4(PRDM16):c.553A>G (p.Met185Val) rs376567517 0.00053
NM_022114.4(PRDM16):c.142G>A (p.Val48Met) rs199968728 0.00051
NM_022114.4(PRDM16):c.481A>G (p.Asn161Asp) rs374664141 0.00048
NM_022114.4(PRDM16):c.3110-4G>A rs201495178 0.00046
NM_022114.4(PRDM16):c.2576C>T (p.Ser859Leu) rs370046582 0.00045
NM_022114.4(PRDM16):c.342G>A (p.Val114=) rs35186069 0.00042
NM_022114.4(PRDM16):c.2142G>A (p.Lys714=) rs200167919 0.00041
NM_022114.4(PRDM16):c.1093G>T (p.Ala365Ser) rs200562747 0.00035
NM_022114.4(PRDM16):c.1566G>T (p.Leu522Phe) rs554705536 0.00034
NM_022114.4(PRDM16):c.1632C>T (p.Asp544=) rs199499877 0.00034
NM_022114.4(PRDM16):c.2281G>A (p.Ala761Thr) rs200947814 0.00029
NM_022114.4(PRDM16):c.885-4G>A rs374365034 0.00029
NM_022114.4(PRDM16):c.1882G>A (p.Asp628Asn) rs199895459 0.00026
NM_022114.4(PRDM16):c.1797G>A (p.Ser599=) rs201769516 0.00021
NM_022114.4(PRDM16):c.2748G>A (p.Ala916=) rs370768364 0.00015
NM_022114.4(PRDM16):c.1187-10G>C rs201517837 0.00014
NM_022114.4(PRDM16):c.1574G>A (p.Arg525Gln) rs373011563 0.00013
NM_022114.4(PRDM16):c.1668G>A (p.Leu556=) rs372910329 0.00013
NM_022114.4(PRDM16):c.884+7C>T rs373228175 0.00013
NM_022114.4(PRDM16):c.1709C>T (p.Thr570Met) rs138655327 0.00011
NM_022114.4(PRDM16):c.1719G>A (p.Ala573=) rs374254884 0.00011
NM_022114.4(PRDM16):c.2223G>A (p.Thr741=) rs756779855 0.00010
NM_022114.4(PRDM16):c.714C>A (p.Leu238=) rs371540074 0.00010
NM_022114.4(PRDM16):c.3301G>A (p.Val1101Met) rs201654872 0.00009
NM_022114.4(PRDM16):c.*15G>A rs771401380 0.00007
NM_022114.4(PRDM16):c.2747C>T (p.Ala916Val) rs756209340 0.00006
NM_022114.4(PRDM16):c.1926C>T (p.Ser642=) rs369294573 0.00005
NM_022114.4(PRDM16):c.3405C>T (p.Ala1135=) rs765114438 0.00005
NM_022114.4(PRDM16):c.1359G>A (p.Pro453=) rs749676367 0.00004
NM_022114.4(PRDM16):c.171C>T (p.Ser57=) rs369648897 0.00004
NM_022114.4(PRDM16):c.2940-15G>A rs538723120 0.00004
NM_022114.4(PRDM16):c.3270G>A (p.Thr1090=) rs375314464 0.00004
NM_022114.4(PRDM16):c.2259C>T (p.Ala753=) rs548246861 0.00003
NM_022114.4(PRDM16):c.843C>T (p.His281=) rs201199516 0.00003
NM_022114.4(PRDM16):c.1665C>A (p.Ala555=) rs768209040 0.00002
NM_022114.4(PRDM16):c.801G>A (p.Glu267=) rs369972213 0.00002
NM_022114.4(PRDM16):c.1807G>A (p.Asp603Asn) rs199984813 0.00001
NM_022114.4(PRDM16):c.2067C>T (p.Ala689=) rs371813954 0.00001
NM_022114.4(PRDM16):c.2169G>A (p.Ser723=) rs775363690 0.00001
NM_022114.4(PRDM16):c.2447A>G (p.Asn816Ser) rs397514743 0.00001
NM_022114.4(PRDM16):c.3288G>A (p.Ala1096=) rs754951901 0.00001
NM_022114.4(PRDM16):c.3792G>A (p.Thr1264=) rs566695262 0.00001
NM_022114.4(PRDM16):c.213del (p.Val72fs) rs1569798933
NM_022114.4(PRDM16):c.2448C>T (p.Asn816=) rs372189819
NM_022114.4(PRDM16):c.2468G>C (p.Arg823Pro) rs371654192
NM_022114.4(PRDM16):c.2685C>T (p.His895=) rs1303585718
NM_022114.4(PRDM16):c.2809C>G (p.Pro937Ala) rs374972823
NM_022114.4(PRDM16):c.2815C>G (p.Leu939Val) rs150022595
NM_022114.4(PRDM16):c.3366CGA[3] (p.Asp1125dup) rs758774731
NM_022114.4(PRDM16):c.574-20_574-17del rs565661633
NM_022114.4(PRDM16):c.677-16_677-11dup rs138423019

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