ClinVar Miner

Variants in gene SDHB with conflicting interpretations

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
693 21 2 16 4 0 1 20

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 8 1 0 0
likely pathogenic 8 0 0 0 0
uncertain significance 1 0 1 2 3
likely benign 0 0 2 0 8
benign 0 0 3 8 1

All variants with conflicting interpretations #

Total variants: 20
Download table as spreadsheet
HGVS dbSNP
NM_003000.2(SDHB):c.136C>T (p.Arg46Ter) rs74315370
NM_003000.2(SDHB):c.158G>A (p.Gly53Glu) rs34916635
NM_003000.2(SDHB):c.24C>T (p.Ser8=) rs148738139
NM_003000.2(SDHB):c.418G>T (p.Val140Phe) rs267607032
NM_003000.2(SDHB):c.424-16_424-14dup rs34261028
NM_003000.2(SDHB):c.424-37TTC[10] rs34261028
NM_003000.2(SDHB):c.541-2A>G rs786201161
NM_003000.2(SDHB):c.543C>T (p.Asp181=) rs199809975
NM_003000.2(SDHB):c.640C>T (p.Gln214Ter) rs876658461
NM_003000.2(SDHB):c.689G>A (p.Arg230His) rs587782604
NM_003000.2(SDHB):c.72+1G>T rs587782703
NM_003000.3(SDHB):c.137G>A (p.Arg46Gln) rs772551056
NM_003000.3(SDHB):c.170A>G (p.His57Arg) rs35962811
NM_003000.3(SDHB):c.287-1G>C rs397516833
NM_003000.3(SDHB):c.300T>C (p.Ser100=) rs11541235
NM_003000.3(SDHB):c.380T>G rs786201095
NM_003000.3(SDHB):c.423+20T>A rs190139590
NM_003000.3(SDHB):c.487T>C (p.Ser163Pro) rs33927012
NM_003000.3(SDHB):c.638T>C (p.Met213Thr) rs202014362
NM_003000.3(SDHB):c.8C>G (p.Ala3Gly) rs11203289

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