ClinVar Miner

Variants in gene VCAN with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
1748 211 0 29 17 0 0 44

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

uncertain significance likely benign benign
uncertain significance 0 14 5
likely benign 14 0 29
benign 5 29 0

All variants with conflicting interpretations #

Total variants: 44
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_004385.5(VCAN):c.6237G>A (p.Lys2079=) rs80200229 0.01278
NM_004385.5(VCAN):c.8622G>A (p.Ala2874=) rs3096171 0.01237
NM_004385.5(VCAN):c.7419C>T (p.Ser2473=) rs61754536 0.00819
NM_004385.5(VCAN):c.4604A>G (p.Glu1535Gly) rs61749614 0.00315
NM_004385.5(VCAN):c.5187G>A (p.Glu1729=) rs35648048 0.00302
NM_004385.5(VCAN):c.1523T>A (p.Ile508Asn) rs143368552 0.00271
NM_004385.5(VCAN):c.9234G>A (p.Glu3078=) rs139453864 0.00270
NM_004385.5(VCAN):c.5750A>T (p.Tyr1917Phe) rs141477510 0.00225
NM_004385.5(VCAN):c.2159T>C (p.Val720Ala) rs76418670 0.00222
NM_004385.5(VCAN):c.2666C>T (p.Thr889Ile) rs149153726 0.00128
NM_004385.5(VCAN):c.1243A>G (p.Ile415Val) rs141268824 0.00127
NM_004385.5(VCAN):c.2028A>G (p.Leu676=) rs147286274 0.00127
NM_004385.5(VCAN):c.2668G>T (p.Gly890Cys) rs146527005 0.00088
NM_004385.5(VCAN):c.6767T>C (p.Leu2256Pro) rs146630369 0.00072
NM_004385.5(VCAN):c.8067G>A (p.Thr2689=) rs113287237 0.00069
NM_004385.5(VCAN):c.1931C>T (p.Pro644Leu) rs148104757 0.00051
NM_004385.5(VCAN):c.7489A>G (p.Lys2497Glu) rs140606678 0.00044
NM_004385.5(VCAN):c.9380-4T>A rs139854446 0.00038
NM_004385.5(VCAN):c.5859G>T (p.Thr1953=) rs80028865 0.00035
NM_004385.5(VCAN):c.3957C>A (p.His1319Gln) rs143393049 0.00032
NM_004385.5(VCAN):c.4762C>A (p.Pro1588Thr) rs151102598 0.00028
NM_004385.5(VCAN):c.9758A>G (p.Asn3253Ser) rs141195210 0.00022
NM_004385.5(VCAN):c.7715C>T (p.Ser2572Leu) rs149032014 0.00019
NM_004385.5(VCAN):c.2234A>C (p.Lys745Thr) rs144502710 0.00018
NM_004385.5(VCAN):c.6322C>G (p.Gln2108Glu) rs62364883 0.00017
NM_004385.5(VCAN):c.221A>G (p.Asn74Ser) rs144766017 0.00016
NM_004385.5(VCAN):c.7065C>T (p.Ile2355=) rs727504214 0.00016
NM_004385.5(VCAN):c.1369G>A (p.Glu457Lys) rs145029761 0.00015
NM_004385.5(VCAN):c.3076A>G (p.Ile1026Val) rs570423677 0.00015
NM_004385.5(VCAN):c.8621C>T (p.Ala2874Val) rs147798761 0.00015
NM_004385.5(VCAN):c.7638C>T (p.Asp2546=) rs144914004 0.00014
NM_004385.5(VCAN):c.7581C>T (p.Phe2527=) rs149880697 0.00013
NM_004385.5(VCAN):c.5489C>T (p.Ser1830Phe) rs141725839 0.00011
NM_004385.5(VCAN):c.2542G>A (p.Glu848Lys) rs188853533 0.00009
NM_004385.5(VCAN):c.9454C>G (p.Leu3152Val) rs183984308 0.00007
NM_004385.5(VCAN):c.2618T>G (p.Ile873Arg) rs150395515 0.00006
NM_004385.5(VCAN):c.1775C>T (p.Thr592Ile) rs536252273 0.00001
NM_004385.5(VCAN):c.5902C>G (p.Gln1968Glu) rs775630677 0.00001
NM_004385.5(VCAN):c.1400C>T (p.Ser467Phe) rs115336789
NM_004385.5(VCAN):c.1458G>T (p.Ser486=) rs150735474
NM_004385.5(VCAN):c.3188T>C (p.Leu1063Pro) rs61754532
NM_004385.5(VCAN):c.6902T>G (p.Phe2301Cys) rs160278
NM_004385.5(VCAN):c.849C>T (p.Leu283=) rs142777690
NM_004385.5(VCAN):c.927T>C (p.Thr309=) rs536465380

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