ClinVar Miner

Variants studied for Hereditary diffuse gastric adenocarcinoma

Coded as:
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
484 140 1869 1146 121 13 3526

Gene and significance breakdown #

Total genes and gene combinations: 7
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
CDH1 433 132 1859 1141 117 13 3451
CTNNA1 46 7 0 2 0 0 55
CDH1, LOC130059290 2 1 5 3 4 0 12
CDH1, LOC112486201, LOC128772402, LOC128772403, LOC128772404, LOC128772405, LOC128772406, LOC128772407, LOC128772408, LOC128772409, LOC128772410, LOC128772411, LOC128772412, LOC128772413, LOC128772414, LOC128822933, LOC128849170, LOC130059290, LOC130059291, LOC130059292, LOC130059293, LOC130059294, LOC130059295, LOC130059296, LOC130059297, LOC130059298 3 0 2 0 0 0 5
CDH1, CDH3 0 0 1 0 0 0 1
CDH1, LOC128772407, LOC128849170 0 0 1 0 0 0 1
KRAS 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 39
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 262 51 1618 1095 69 0 3095
Myriad Genetics, Inc. 256 78 87 17 19 0 457
European Reference Network on Genetic Tumour Risk Syndromes (ERN-GENTURIS), i3s - Instituto de Investigação e Inovação em Saúde, University of Porto 84 12 227 35 33 0 391
Counsyl 4 8 91 41 2 0 146
Illumina Laboratory Services, Illumina 0 0 46 23 41 0 110
Mendelics 3 2 27 19 15 0 66
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 12 3 3 0 18
OMIM 15 0 0 0 0 0 15
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 10 5 0 0 0 0 15
Department of Pathology and Laboratory Medicine, Sinai Health System 1 0 5 5 0 0 11
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 9 9
Pathway Genomics 4 0 2 1 1 0 8
MGZ Medical Genetics Center 3 1 3 0 0 0 7
Institute of Human Genetics, University of Leipzig Medical Center 2 0 2 1 0 0 5
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 4 0 0 0 4
CSER _CC_NCGL, University of Washington 1 0 2 0 0 0 3
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 0 3 0 0 0 3
GenomeConnect, ClinGen 0 0 0 0 0 3 3
University of Washington Department of Laboratory Medicine, University of Washington 0 0 0 3 0 0 3
GenomeConnect - No Stomach For Cancer 0 0 0 0 0 3 3
Genome-Nilou Lab 0 0 0 0 3 0 3
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 0 1 2 0 0 0 3
Laboratório de Genética Humana e Médica, Universidade Federal do Pará 1 0 0 0 0 1 2
Immunopatologia e Biomarcatori Oncologici/Bio-proteomics facility, Centro di Riferimento Oncologico 2 0 0 0 0 0 2
Pittsburgh Clinical Genomics Laboratory, University of Pittsburgh Medical Center 0 0 2 0 0 0 2
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center 0 0 2 0 0 0 2
Baylor Genetics 0 0 1 0 0 0 1
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 0 1 0 0 0 1
Fundacion Rioja Salud, Center for Biomedical Research (CIBIR) 1 0 0 0 0 0 1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 1 0 0 0 0 1
Undiagnosed Diseases Network, NIH 0 1 0 0 0 0 1
Familial Cancer Clinical Unit, Spanish National Cancer Research Centre (CNIO) 1 0 0 0 0 0 1
GeneID Lab - Advanced Molecular Diagnostics 0 1 0 0 0 0 1
Cancer Variant Interpretation Group UK, Institute of Cancer Research, London 0 0 1 0 0 0 1
ClinGen CDH1 Variant Curation Expert Panel 0 0 0 0 1 0 1
Division of Medical Genetics, University of Washington 0 0 1 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 1 0 0 0 0 0 1
Human Genetics Bochum, Ruhr University Bochum 0 0 1 0 0 0 1
Medizinische Genetik Mainz, Limbach Genetics GmbH 0 0 1 0 0 0 1

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