ClinVar Miner

Variants studied for gastric cancer

Included ClinVar conditions (19):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
1042 512 1976 1184 125 20 4591

Gene and significance breakdown #

Total genes and gene combinations: 70
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
CDH1 437 134 1865 1141 117 18 3461
TP53 14 158 0 0 0 0 165
BRCA2 90 0 0 0 0 0 90
APC 23 3 44 11 2 2 85
CTNNA1 51 7 0 2 0 0 60
ATM 55 0 0 0 0 0 55
MUTYH 29 4 19 3 1 0 55
FGFR2 5 5 25 16 1 0 51
PIK3CA 4 43 1 0 0 0 45
BRCA1 31 0 0 0 0 0 31
MSH6 29 0 0 0 0 0 29
ATM, C11orf65 28 0 0 0 0 0 28
BRIP1 26 0 0 0 0 0 26
PALB2 26 0 0 0 0 0 26
CTNNB1, LOC126806658 0 21 0 0 0 0 21
NF1 20 0 0 0 0 0 20
BARD1 19 0 0 0 0 0 19
CHEK2 19 0 0 0 0 0 19
KRAS 4 2 5 6 0 0 16
ERBB2 1 14 0 0 0 0 14
FBXW7 0 14 0 0 0 0 14
MSH2 14 0 0 0 0 0 14
NRAS 0 14 0 0 0 0 14
PTEN 9 5 0 0 0 0 14
EPCAM 13 0 0 0 0 0 13
HRAS, LRRC56 0 13 0 0 0 0 13
NBN 13 0 0 0 0 0 13
RAD51D, RAD51L3-RFFL 13 0 0 0 0 0 13
CDH1, LOC130059290 2 1 5 3 4 0 12
MLH1 11 1 0 0 0 0 12
RAD51C 11 0 0 0 0 0 11
SMAD4 2 9 0 0 0 0 11
PMS2 10 0 0 0 0 0 10
BRCA1, LOC126862571 8 0 0 0 0 0 8
CDKN2A 1 7 0 0 0 0 8
RHOA 0 8 0 0 0 0 8
HOXB13 6 0 0 0 0 0 6
B2M 0 5 0 0 0 0 5
CASP10 2 0 3 0 0 0 5
CDH1, LOC112486201, LOC128772402, LOC128772403, LOC128772404, LOC128772405, LOC128772406, LOC128772407, LOC128772408, LOC128772409, LOC128772410, LOC128772411, LOC128772412, LOC128772413, LOC128772414, LOC128822933, LOC128849170, LOC130059290, LOC130059291, LOC130059292, LOC130059293, LOC130059294, LOC130059295, LOC130059296, LOC130059297, LOC130059298 3 0 2 0 0 0 5
ERBB3 0 5 0 0 0 0 5
IL1RN 0 0 3 2 0 0 5
MAP2K1 0 5 0 0 0 0 5
CREBBP 0 4 0 0 0 0 4
MUTYH, TOE1 3 0 1 0 0 0 4
APC, LOC129994371 3 0 0 0 0 0 3
BRAF 0 3 0 0 0 0 3
FGFR1 0 3 0 0 0 0 3
GNAS 0 3 0 0 0 0 3
PPP2R1A 0 3 0 0 0 0 3
ACVR1 0 2 0 0 0 0 2
CDH1, CDH3 0 0 2 0 0 0 2
CNOT9 0 2 0 0 0 0 2
KIT 0 2 0 0 0 0 2
MAP2K2 0 2 0 0 0 0 2
MED12 0 2 0 0 0 0 2
MTOR 0 2 0 0 0 0 2
RAF1 0 2 0 0 0 0 2
AKT1 0 1 0 0 0 0 1
CDH1, LOC128772407, LOC128849170 0 0 1 0 0 0 1
CDK4 1 0 0 0 0 0 1
CDKN2A, LOC130001603 1 0 0 0 0 0 1
FANCI 0 1 0 0 0 0 1
IRF1 1 0 0 0 0 0 1
KLF6 1 0 0 0 0 0 1
LOC126860438, NBN 1 0 0 0 0 0 1
LOC130062899, STK11 1 0 0 0 0 0 1
POLE 0 1 0 0 0 0 1
PTPN11 0 1 0 0 0 0 1
STK11 1 0 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 54
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Labcorp Genetics (formerly Invitae), Labcorp 265 52 1622 1095 69 0 3103
Laboratory for Genotyping Development, RIKEN 518 0 0 0 0 0 518
Myriad Genetics, Inc. 262 78 87 17 19 0 463
European Reference Network on Genetic Tumour Risk Syndromes (ERN-GENTURIS), i3s - Instituto de Investigação e Inovação em Saúde, University of Porto 84 12 227 35 33 0 391
Database of Curated Mutations (DoCM) 0 360 0 0 0 0 360
Fulgent Genetics, Fulgent Genetics 27 5 109 47 6 0 194
Counsyl 4 8 91 41 2 0 146
Illumina Laboratory Services, Illumina 0 0 46 23 41 0 110
Mendelics 3 2 26 19 15 0 65
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 0 0 13 3 3 0 19
OMIM 18 0 0 0 0 0 18
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 12 5 0 0 0 0 17
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 13 13
Department of Pathology and Laboratory Medicine, Sinai Health System 1 0 5 5 0 0 11
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 4 0 5 0 0 0 9
MGZ Medical Genetics Center 3 1 4 0 0 0 8
Pathway Genomics 4 0 2 1 1 0 8
Institute of Human Genetics, University of Leipzig Medical Center 2 0 2 1 0 0 5
GenomeConnect, ClinGen 0 0 0 0 0 5 5
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 5 0 0 0 5
GenomeConnect - No Stomach For Cancer 0 0 0 0 0 4 4
Laboratorio de Genetica e Diagnostico Molecular, Hospital Israelita Albert Einstein 1 1 2 0 0 0 4
CSER _CC_NCGL, University of Washington 1 0 2 0 0 0 3
Knight Diagnostic Laboratories, Oregon Health and Sciences University 0 0 3 0 0 0 3
University of Washington Department of Laboratory Medicine, University of Washington 0 0 0 3 0 0 3
Genome-Nilou Lab 0 0 0 0 3 0 3
Department of Human Genetics, Hannover Medical School 0 0 3 0 0 0 3
Baylor Genetics 0 1 1 0 0 0 2
King Laboratory, University of Washington 2 0 0 0 0 0 2
Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center 0 0 2 0 0 0 2
Laboratório de Genética Humana e Médica, Universidade Federal do Pará 1 0 0 0 0 1 2
Immunopatologia e Biomarcatori Oncologici/Bio-proteomics facility, Centro di Riferimento Oncologico 2 0 0 0 0 0 2
Pittsburgh Clinical Genomics Laboratory, University of Pittsburgh Medical Center 0 0 2 0 0 0 2
Solve-RD Consortium 0 2 0 0 0 0 2
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 0 1 0 0 0 1
Fundacion Rioja Salud, Center for Biomedical Research (CIBIR) 1 0 0 0 0 0 1
Soonchunhyang University Bucheon Hospital, Soonchunhyang University Medical Center 0 1 0 0 0 0 1
Undiagnosed Diseases Network, NIH 0 1 0 0 0 0 1
Leiden Open Variation Database 0 1 0 0 0 0 1
Familial Cancer Clinical Unit, Spanish National Cancer Research Centre (CNIO) 1 0 0 0 0 0 1
GeneID Lab - Advanced Molecular Diagnostics 0 1 0 0 0 0 1
3DMed Clinical Laboratory Inc 0 0 1 0 0 0 1
Cancer Variant Interpretation Group UK, Institute of Cancer Research, London 0 0 1 0 0 0 1
ClinGen CDH1 Variant Curation Expert Panel 0 0 0 0 1 0 1
Diagnostics Services (NGS), CSIR - Centre For Cellular And Molecular Biology 0 0 1 0 0 0 1
Division of Medical Genetics, University of Washington 0 0 1 0 0 0 1
Dr. med. U. Finckh, Human Genetics, Eurofins MVZ 1 0 0 0 0 0 1
3billion 0 0 0 1 0 0 1
Medical Genetics Laboratory, Umraniye Training and Research Hospital, University of Health Sciences 0 1 0 0 0 0 1
Clinical Genomics, Uppaluri K&H Personalized Medicine Clinic 0 1 0 0 0 0 1
Human Genetics Bochum, Ruhr University Bochum 0 0 1 0 0 0 1
Institute of Immunology and Genetics Kaiserslautern 1 0 0 0 0 0 1
Molecular Genetics and NGS Laboratory, Hospital Fundacion Valle Del Lili 0 1 0 0 0 0 1
MVZ Medizinische Genetik Mainz 0 0 1 0 0 0 1

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