ClinVar Miner

Variants studied for mixed neoplasm

Included ClinVar conditions (19):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
256 49 1551 922 140 3 6 5 2860

Gene and significance breakdown #

Total genes and gene combinations: 23
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
GPC3 45 9 454 309 69 0 0 0 865
WT1 55 18 419 354 40 0 0 4 861
LOC107982234, WT1 21 4 468 229 13 0 0 0 713
BRCA2 124 16 147 28 17 0 0 1 333
REST 0 0 51 2 0 3 0 0 56
TRIM28 1 0 8 0 0 0 0 0 9
CTNNB1, LOC126806658 0 0 0 0 0 0 2 0 2
H19, H19-ICR, MRPL23 2 0 0 0 0 0 0 0 2
LOC106707172, LOC107982234, LOC130005479, WT1 2 0 0 0 0 0 0 0 2
LOC130065239, TRIM28 0 0 2 0 0 0 0 0 2
MED12 0 0 1 0 0 0 1 0 2
POU6F2 2 0 0 0 0 0 0 0 2
BRAF 1 0 0 0 0 0 0 0 1
CCDC160, GPC3, HPRT1, MIR106A, MIR19B2, PHF6 1 0 0 0 0 0 0 0 1
CHEK2 1 0 0 0 0 0 0 0 1
CTNNB1 0 0 0 0 0 0 1 0 1
DCDC1, DNAJC24, ELP4, IMMP1L, PAX6, RCN1, WT1 1 0 0 0 0 0 0 0 1
DIS3L2 0 1 0 0 0 0 0 0 1
FZD6 0 0 0 0 0 0 1 0 1
GPC4 0 0 0 0 1 0 0 0 1
IGF2, INS-IGF2 0 1 0 0 0 0 0 0 1
SMAD4 0 0 1 0 0 0 0 0 1
TET2 0 0 0 0 0 0 1 0 1

Submitter and significance breakdown #

Total submitters: 35
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Labcorp Genetics (formerly Invitae), Labcorp 109 19 1165 842 102 0 0 0 2237
Fulgent Genetics, Fulgent Genetics 115 11 334 58 18 0 0 0 536
All of Us Research Program, National Institutes of Health 0 2 173 100 4 0 0 0 279
Illumina Laboratory Services, Illumina 0 0 72 14 25 0 0 0 111
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 7 1 32 0 0 0 0 0 40
Juno Genomics, Hangzhou Juno Genomics, Inc 21 10 0 0 0 0 0 0 31
Genome-Nilou Lab 0 0 0 0 18 0 0 0 18
OMIM 13 0 0 0 0 3 0 0 16
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 3 10 0 0 0 13
Mendelics 0 0 11 0 1 0 0 0 12
Baylor Genetics 4 2 4 0 0 0 0 0 10
Color Diagnostics, LLC DBA Color Health 0 0 0 2 8 0 0 0 10
Donald Williams Parsons Laboratory, Baylor College of Medicine 2 1 0 0 0 0 6 0 9
GeneReviews 0 0 0 0 0 0 0 3 3
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn 3 0 0 0 0 0 0 0 3
Molecular Genetics and NGS Laboratory, Hospital Fundacion Valle Del Lili 2 1 0 0 0 0 0 0 3
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 0 1 1 0 0 0 0 0 2
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 2 0 0 0 0 0 2
Genetics and Molecular Pathology, SA Pathology 1 1 0 0 0 0 0 0 2
Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet 1 0 0 0 0 0 0 0 1
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 0 0 0 1 0 0 0 0 1
Institute of Human Genetics, Cologne University 1 0 0 0 0 0 0 0 1
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 1 0 0 0 0 0 0 0 1
Institute for Human Genetics and Genomic Medicine, Uniklinik RWTH Aachen 0 1 0 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 0 0 1 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 0 0 1
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 1 0 0 0 0 0 0 0 1
Génétique des Maladies du Développement, Hospices Civils de Lyon 0 0 1 0 0 0 0 0 1
Johns Hopkins Genomics, Johns Hopkins University 1 0 0 0 0 0 0 0 1
Pediatric Oncology, Johns Hopkins University 1 0 0 0 0 0 0 0 1
NPCF Sunshine Lab, H. Lee Moffitt Cancer Center and Research Institute 1 0 0 0 0 0 0 0 1
3billion, Medical Genetics 0 0 0 1 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 0 1 1
Laan Lab, Human Genetics Research Group, University of Tartu 0 1 0 0 0 0 0 0 1
MVZ Medizinische Genetik Mainz 1 0 0 0 0 0 0 0 1

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