ClinVar Miner

Variants studied for adrenal gland neoplasm

Included ClinVar conditions (41):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
624 290 2128 451 106 9 3473

Gene and significance breakdown #

Total genes and gene combinations: 37
Download table as spreadsheet
Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
SDHA 37 19 452 60 6 0 563
MEN1 125 36 296 52 10 5 512
SDHB 102 37 216 28 5 2 370
LOC107303340, VHL 104 39 172 40 13 0 352
RET 55 19 175 79 19 1 311
VHL 76 27 159 20 4 0 269
SDHC 14 10 156 21 16 0 213
SDHD 51 12 132 18 7 1 213
TMEM127 12 21 135 41 3 0 204
KIF1B 1 0 91 52 8 0 152
SDHAF2 4 2 73 10 4 0 93
MAX 6 1 50 27 7 0 91
TP53 5 40 4 0 0 0 48
CLCN2 11 0 1 0 0 0 12
CTNNB1 0 11 0 0 0 0 11
LOC100506321, MAX 3 0 3 1 0 0 7
LOC106736614, RET 0 0 4 1 1 0 6
NRAS 0 5 0 0 0 0 5
USP8 5 0 0 0 0 0 5
BRK1, FANCD2, FANCD2OS, LOC107303338, LOC107303339, LOC107303340, VHL 2 0 2 0 0 0 4
LOC110121224, TMEM127 2 0 2 0 0 0 4
PIK3CA 0 4 0 0 0 0 4
AIP 1 0 2 0 0 0 3
ATP1A1 3 0 0 0 0 0 3
ATP2B3 3 0 0 0 0 0 3
BRAF 0 3 0 0 0 0 3
GNAS 0 3 0 0 0 0 3
MPZ, SDHC 0 0 0 0 2 0 2
PADI2, SDHB 2 0 0 0 0 0 2
​intergenic 1 0 0 0 0 0 1
ADAMTS4, APOA2, ARHGAP30, B4GALT3, CD244, DEDD, F11R, FCER1G, ITLN1, ITLN2, KLHDC9, LOC101928372, LOC112543491, LY9, MIR5187, MPZ, NDUFS2, NECTIN4, NIT1, NR1I3, PCP4L1, PFDN2, PPOX, SDHC, TOMM40L, TSTD1, UFC1, USF1, USP21 0 0 1 0 0 0 1
CFAP126, SDHC 0 0 0 0 1 0 1
CHEK2 0 0 1 0 0 0 1
GNAI2 1 0 0 0 0 0 1
H3-3A 0 1 0 0 0 0 1
LOC110121502, MCS+9.7, RET 0 0 0 1 0 0 1
ZMYND11 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 50
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 335 81 1578 115 9 0 2117
Illumina Clinical Services Laboratory,Illumina 0 0 362 235 62 0 659
Counsyl 10 11 176 80 11 0 288
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 121 35 35 7 6 0 204
OMIM 126 0 0 0 0 0 126
Mendelics 6 5 65 14 14 0 104
Integrated Genetics/Laboratory Corporation of America 43 25 4 3 3 5 83
Section on Medical Neuroendocrinolgy,National Institutes of Health 59 13 8 0 0 0 80
Database of Curated Mutations (DoCM) 0 79 0 0 0 0 79
Fulgent Genetics,Fulgent Genetics 15 3 58 0 0 0 76
Laboratory for Molecular Medicine, Partners HealthCare Personalized Medicine 25 13 0 0 0 0 38
Center for Human Genetics, Inc 27 5 4 1 0 0 37
Research and Development, ARUP Laboratories 30 0 1 0 0 0 31
Familial Cancer Clinic,Veneto Institute of Oncology 0 19 0 0 0 0 19
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories 7 1 2 2 5 0 17
CSER _CC_NCGL, University of Washington 0 0 8 7 0 0 15
Institute of Human Genetics,Klinikum rechts der Isar 12 0 0 0 0 0 12
GeneReviews 11 0 0 0 0 0 11
Endocrinology Clinic, Seth G.S. Medical College 0 10 0 0 0 0 10
Human Genome Sequencing Center Clinical Lab,Baylor College of Medicine 6 1 0 0 0 0 7
Equipe Genetique des Anomalies du Developpement, Université de Bourgogne 0 0 5 0 2 0 7
Ute Scholl Laboratory,Heinrich Heine University Duesseldorf 5 0 0 0 0 0 5
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 4 0 0 0 0 0 4
Genetic Services Laboratory, University of Chicago 2 2 0 0 0 0 4
GenomeConnect, ClinGen 0 0 0 0 0 4 4
CIViC knowledgebase,Washington University School of Medicine 3 1 0 0 0 0 4
HudsonAlpha Institute for Biotechnology, HudsonAlpha Institute for Biotechnology 3 0 0 0 0 0 3
Department of Pediatrics,Memorial Sloan Kettering Cancer Center 3 0 0 0 0 0 3
Biesecker Lab/Clinical Genomics Section,National Institutes of Health 1 1 0 0 0 0 2
Institute of Human Genetics,Cologne University 1 0 1 0 0 0 2
UCLA Clinical Genomics Center, UCLA 2 0 0 0 0 0 2
Knight Diagnostic Laboratories,Oregon Health and Sciences University 0 0 2 0 0 0 2
Donald Williams Parsons Laboratory,Baylor College of Medicine 1 1 0 0 0 0 2
Geisinger Autism and Developmental Medicine Institute,Geisinger Health System 2 0 0 0 0 0 2
PreventionGenetics,PreventionGenetics 0 0 1 0 0 0 1
Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics 0 1 0 0 0 0 1
Center of Genomic medicine, Geneva,University Hospital of Geneva 1 0 0 0 0 0 1
Center for Human Genetics,University of Leuven 0 1 0 0 0 0 1
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 1 0 0 0 1
Undiagnosed Diseases Network,NIH 1 0 0 0 0 0 1
Genetics,Medical University of Vienna 0 1 0 0 0 0 1
Rady Children's Institute for Genomic Medicine, Rady Children's Hospital San Diego 1 0 0 0 0 0 1
Diagnostic Laboratory, Department of Genetics,University Medical Center Groningen 0 0 0 1 0 0 1
Biochemical Molecular Genetic Laboratory,King Abdulaziz Medical City 0 1 0 0 0 0 1
Molecular Diagnostics Laboratory, M Health: University of Minnesota 1 0 0 0 0 0 1
Department of Genetics,Sultan Qaboos University Hospital, Oman 0 0 1 0 0 0 1
Department of Laboratory Medicine,Soonchunhyang University Seoul Hospital 1 0 0 0 0 0 1
Johns Hopkins Genomics,Johns Hopkins University 1 0 0 0 0 0 1
University of Washington Department of Laboratory Medicine, University of Washington 0 0 0 0 1 0 1
Cancer medicine,Gaomi People's Hospital 1 0 0 0 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.