ClinVar Miner

Variants studied for adrenal gland neoplasm

Included ClinVar conditions (39):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign not provided total
548 269 1781 799 144 9 3399

Gene and significance breakdown #

Total genes and gene combinations: 36
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign not provided total
SDHA 25 16 368 184 19 0 587
MEN1 101 31 235 144 23 4 524
LOC107303340, VHL 92 34 160 57 13 0 342
SDHB 85 38 171 48 9 2 331
RET 55 19 174 73 12 2 301
VHL 73 24 127 48 7 0 265
SDHC 12 8 130 41 18 0 204
SDHD 47 10 104 33 8 1 196
TMEM127 11 21 106 58 10 0 193
KIF1B 1 0 91 52 8 0 152
MAX 5 0 45 36 7 0 93
SDHAF2 4 1 54 21 6 0 84
TP53 5 40 4 0 0 0 48
CLCN2 11 0 1 0 0 0 12
CTNNB1 0 11 0 0 0 0 11
LOC106736614, RET 0 0 4 1 1 0 6
LOC100506321, MAX 2 0 1 2 0 0 5
NRAS 0 5 0 0 0 0 5
USP8 5 0 0 0 0 0 5
PIK3CA 0 4 0 0 0 0 4
AIP 1 0 2 0 0 0 3
ATP1A1 3 0 0 0 0 0 3
ATP2B3 3 0 0 0 0 0 3
BRAF 0 3 0 0 0 0 3
GNAS 0 3 0 0 0 0 3
LOC110121224, TMEM127 2 0 1 0 0 0 3
BRK1, FANCD2, FANCD2OS, LOC107303338, LOC107303339, LOC107303340, VHL 1 0 1 0 0 0 2
MPZ, SDHC 0 0 0 0 2 0 2
PADI2, SDHB 2 0 0 0 0 0 2
​intergenic 1 0 0 0 0 0 1
CFAP126, SDHC 0 0 0 0 1 0 1
CHEK2 0 0 1 0 0 0 1
GNAI2 1 0 0 0 0 0 1
H3F3A 0 1 0 0 0 0 1
LOC110121502, MCS+9.7, RET 0 0 0 1 0 0 1
ZMYND11 0 0 1 0 0 0 1

Submitter and significance breakdown #

Total submitters: 46
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign not provided total
Invitae 251 67 1228 495 69 0 2110
Illumina Clinical Services Laboratory,Illumina 0 0 362 235 62 0 659
Counsyl 10 11 176 80 11 0 288
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 121 35 35 7 6 0 204
OMIM 123 0 0 0 0 0 123
Integrated Genetics/Laboratory Corporation of America 43 25 4 3 3 5 83
Section on Medical Neuroendocrinolgy,National Institutes of Health 59 13 8 0 0 0 80
Database of Curated Mutations (DoCM) 0 79 0 0 0 0 79
Fulgent Genetics 15 3 58 0 0 0 76
Mendelics 3 2 55 2 2 0 64
Center for Human Genetics, Inc 27 5 4 1 0 0 37
Laboratory for Molecular Medicine,Partners HealthCare Personalized Medicine 23 11 0 0 0 0 34
ARUP Institute,ARUP Laboratories 31 0 0 0 0 0 31
Familial Cancer Clinic,Veneto Institute of Oncology 0 19 0 0 0 0 19
CSER_CC_NCGL; University of Washington Medical Center 0 0 8 7 0 0 15
Institute of Human Genetics,Klinikum rechts der Isar 12 0 0 0 0 0 12
GeneReviews 11 0 0 0 0 0 11
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics 10 0 0 0 0 0 10
Endocrinology Clinic, Seth G.S. Medical College 0 10 0 0 0 0 10
Human Genome Sequencing Center Clinical Lab,Baylor College of Medicine 6 1 0 0 0 0 7
Equipe Genetique des Anomalies du Developpement,Université de Bourgogne 0 0 5 0 2 0 7
Ute Scholl Laboratory,Heinrich Heine University Duesseldorf 5 0 0 0 0 0 5
Clinical Molecular Genetics Laboratory,Johns Hopkins All Children's Hospital 4 0 0 0 0 0 4
Genetic Services Laboratory, University of Chicago 2 2 0 0 0 0 4
Department of Pediatrics,Memorial Sloan Kettering Cancer Center 3 0 0 0 0 0 3
GenomeConnect, ClinGen 0 0 0 0 0 3 3
UCLA Clinical Genomics Center, UCLA 2 0 0 0 0 0 2
Knight Diagnostic Laboratories,Oregon Health and Sciences University 0 0 2 0 0 0 2
Donald Williams Parsons Laboratory,Baylor College of Medicine 1 1 0 0 0 0 2
Geisinger Autism and Developmental Medicine Institute,Geisinger Health System 2 0 0 0 0 0 2
Biesecker Lab/Human Development Section,National Institutes of Health 1 0 0 0 0 0 1
PreventionGenetics 0 0 1 0 0 0 1
Institute of Human Genetics,Cologne University 1 0 0 0 0 0 1
ClinVar Staff, National Center for Biotechnology Information (NCBI) 0 0 0 0 0 1 1
HudsonAlpha Institute for Biotechnology 1 0 0 0 0 0 1
Foundation for Research in Genetics and Endocrinology,Institute of Human Genetics 0 1 0 0 0 0 1
Center of Genomic medicine, Geneva,University Hospital of Geneva 1 0 0 0 0 0 1
Center for Human Genetics,University of Leuven 0 1 0 0 0 0 1
Centre for Mendelian Genomics,University Medical Centre Ljubljana 0 0 1 0 0 0 1
Undiagnosed Diseases Network,NIH 0 0 1 0 0 0 1
Genetics,Medical University of Vienna 0 1 0 0 0 0 1
Diagnostic Laboratory, Department of Genetics,University Medical Center Groningen 0 0 0 1 0 0 1
Molecular Diagnostics Laboratory,M Health: University of Minnesota 1 0 0 0 0 0 1
Department of Genetics,Sultan Qaboos University Hospital, Oman 0 0 1 0 0 0 1
Department of Laboratory Medicine,Soonchunhyang University Seoul Hospital 1 0 0 0 0 0 1
University of Washington Department of Laboratory Medicine,University of Washington 0 0 0 0 1 0 1

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