ClinVar Miner

Variants in gene LAMC3 with conflicting interpretations

See also:
Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
1300 135 0 58 40 0 3 93

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign
pathogenic 0 3 3 0 0
likely pathogenic 3 0 1 0 0
uncertain significance 3 1 0 40 6
likely benign 0 0 40 0 55
benign 0 0 6 55 0

All variants with conflicting interpretations #

Total variants: 93
Download table as spreadsheet
HGVS dbSNP gnomAD frequency
NM_006059.4(LAMC3):c.219T>G (p.His73Gln) rs3739512 0.56936
NM_006059.4(LAMC3):c.1932C>T (p.Ser644=) rs12349966 0.48282
NM_006059.4(LAMC3):c.963C>T (p.Ala321=) rs2275131 0.40359
NM_006059.4(LAMC3):c.4378-4A>G rs4740413 0.38051
NM_006059.4(LAMC3):c.3114C>G (p.Leu1038=) rs10901345 0.33677
NM_006059.4(LAMC3):c.3108G>A (p.Gly1036=) rs10901344 0.33663
NM_006059.4(LAMC3):c.521C>A (p.Pro174His) rs2275137 0.29468
NM_006059.4(LAMC3):c.4298C>T (p.Thr1433Met) rs7024108 0.28739
NM_006059.4(LAMC3):c.1564C>T (p.Pro522Ser) rs869457 0.28273
NM_006059.4(LAMC3):c.4231-10C>T rs4740411 0.20977
NM_006059.4(LAMC3):c.4376G>A (p.Arg1459Gln) rs4740412 0.20674
NM_006059.4(LAMC3):c.1218G>A (p.Thr406=) rs2293518 0.20549
NM_006059.4(LAMC3):c.3507C>T (p.Thr1169=) rs3818800 0.14515
NM_006059.4(LAMC3):c.75C>T (p.Cys25=) rs13286358 0.10217
NM_006059.4(LAMC3):c.1047C>T (p.Gly349=) rs45603838 0.06722
NM_006059.4(LAMC3):c.3790C>T (p.Arg1264Trp) rs11244275 0.04427
NM_006059.4(LAMC3):c.92G>T (p.Arg31Leu) rs116259120 0.02047
NM_006059.4(LAMC3):c.2559C>T (p.Ser853=) rs34652877 0.01902
NM_006059.4(LAMC3):c.-2C>T rs137883250 0.01424
NM_006059.4(LAMC3):c.4561T>G (p.Ser1521Ala) rs117361076 0.01275
NM_006059.4(LAMC3):c.454C>T (p.Arg152Cys) rs45628035 0.00975
NM_006059.4(LAMC3):c.2516C>T (p.Thr839Met) rs57816762 0.00893
NM_006059.4(LAMC3):c.2039C>T (p.Thr680Met) rs73658916 0.00851
NM_006059.4(LAMC3):c.3371C>T (p.Ser1124Phe) rs113259170 0.00738
NM_006059.4(LAMC3):c.2352G>A (p.Arg784=) rs35654564 0.00652
NM_006059.4(LAMC3):c.146A>G (p.Gln49Arg) rs201962705 0.00645
NM_006059.4(LAMC3):c.2438G>A (p.Ser813Asn) rs55741126 0.00598
NM_006059.4(LAMC3):c.786G>A (p.Val262=) rs2275133 0.00543
NM_006059.4(LAMC3):c.517C>T (p.Arg173Trp) rs145775274 0.00378
NM_006059.4(LAMC3):c.4092C>T (p.Ser1364=) rs141724499 0.00360
NM_006059.4(LAMC3):c.2891-8C>T rs199535979 0.00339
NM_006059.4(LAMC3):c.2517G>A (p.Thr839=) rs140540789 0.00292
NM_006059.4(LAMC3):c.368G>T (p.Arg123Leu) rs140461419 0.00284
NM_006059.4(LAMC3):c.4160C>T (p.Ala1387Val) rs141497885 0.00258
NM_006059.4(LAMC3):c.3927+8C>G rs148008251 0.00228
NM_006059.4(LAMC3):c.3347C>G (p.Ala1116Gly) rs36028197 0.00226
NM_006059.4(LAMC3):c.4130C>T (p.Thr1377Ile) rs144662546 0.00189
NM_006059.4(LAMC3):c.1630+5C>G rs184221540 0.00178
NM_006059.4(LAMC3):c.1520-6G>A rs192031352 0.00175
NM_006059.4(LAMC3):c.4477+9G>T rs201360815 0.00141
NM_006059.4(LAMC3):c.2066C>T (p.Pro689Leu) rs113443891 0.00123
NM_006059.4(LAMC3):c.1283+15C>T rs369184450 0.00108
NM_006059.4(LAMC3):c.558C>T (p.Arg186=) rs2275135 0.00105
NM_006059.4(LAMC3):c.2276G>A (p.Gly759Asp) rs150859618 0.00084
NM_006059.4(LAMC3):c.2227A>G (p.Asn743Asp) rs36030184 0.00079
NM_006059.4(LAMC3):c.3374C>T (p.Ser1125Leu) rs151213335 0.00078
NM_006059.4(LAMC3):c.3674T>C (p.Val1225Ala) rs138481447 0.00068
NM_006059.4(LAMC3):c.2987G>A (p.Arg996His) rs113785045 0.00063
NM_006059.4(LAMC3):c.3319G>A (p.Gly1107Arg) rs144118534 0.00060
NM_006059.4(LAMC3):c.1547T>G (p.Val516Gly) rs549607103 0.00054
NM_006059.4(LAMC3):c.2238G>A (p.Ala746=) rs141918703 0.00044
NM_006059.4(LAMC3):c.480C>T (p.Tyr160=) rs140728983 0.00044
NM_006059.4(LAMC3):c.1019G>A (p.Arg340Gln) rs149004188 0.00037
NM_006059.4(LAMC3):c.2619G>A (p.Ser873=) rs139268056 0.00035
NM_006059.4(LAMC3):c.290A>G (p.Gln97Arg) rs141758463 0.00031
NM_006059.4(LAMC3):c.4415G>A (p.Arg1472Gln) rs137894550 0.00029
NM_006059.4(LAMC3):c.2390C>T (p.Pro797Leu) rs150965854 0.00018
NM_006059.4(LAMC3):c.2468A>G (p.Asn823Ser) rs140325029 0.00017
NM_006059.4(LAMC3):c.1051C>T (p.Arg351Cys) rs201626968 0.00014
NM_006059.4(LAMC3):c.944G>A (p.Arg315Gln) rs45444592 0.00012
NM_006059.4(LAMC3):c.4119G>A (p.Thr1373=) rs201780404 0.00011
NM_006059.4(LAMC3):c.696C>T (p.Thr232=) rs372132123 0.00009
NM_006059.4(LAMC3):c.2949C>T (p.Cys983=) rs373660982 0.00008
NM_006059.4(LAMC3):c.4068G>A (p.Ala1356=) rs377618961 0.00008
NM_006059.4(LAMC3):c.3871C>T (p.Arg1291Ter) rs201793200 0.00006
NM_006059.4(LAMC3):c.4660C>T (p.Arg1554Cys) rs375971925 0.00006
NM_006059.4(LAMC3):c.3566C>T (p.Ala1189Val) rs369839636 0.00004
NM_006059.4(LAMC3):c.686T>C (p.Val229Ala) rs149485800 0.00004
NM_006059.4(LAMC3):c.1048G>A (p.Gly350Arg) rs571785750 0.00003
NM_006059.4(LAMC3):c.4348C>T (p.Arg1450Cys) rs201785610 0.00003
NM_006059.4(LAMC3):c.4477+3A>G rs202112145 0.00003
NM_006059.4(LAMC3):c.976+1G>C rs201519274 0.00003
NM_006059.4(LAMC3):c.1130G>A (p.Arg377Gln) rs375139277 0.00002
NM_006059.4(LAMC3):c.3624G>A (p.Glu1208=) rs569440839 0.00002
NM_006059.4(LAMC3):c.1414C>A (p.His472Asn) rs145387373 0.00001
NM_006059.4(LAMC3):c.4031-10G>A rs555619019 0.00001
NM_006059.4(LAMC3):c.4031-4G>A rs765657893 0.00001
NM_006059.4(LAMC3):c.4698C>T (p.Ser1566=) rs754122699 0.00001
NM_006059.4(LAMC3):c.1939G>C (p.Gly647Arg) rs144242690
NM_006059.4(LAMC3):c.2308C>G (p.Arg770Gly) rs3739510
NM_006059.4(LAMC3):c.2438_2439delinsAG (p.Ser813Lys) rs386738959
NM_006059.4(LAMC3):c.2439C>G (p.Ser813Arg) rs61637370
NM_006059.4(LAMC3):c.3069+8G>T rs563444562
NM_006059.4(LAMC3):c.3070-18dup rs34910694
NM_006059.4(LAMC3):c.3250G>C (p.Glu1084Gln) rs146221263
NM_006059.4(LAMC3):c.3379G>A (p.Glu1127Lys) rs140955110
NM_006059.4(LAMC3):c.4146G>A (p.Arg1382=) rs147092908
NM_006059.4(LAMC3):c.4146G>C (p.Arg1382Ser) rs147092908
NM_006059.4(LAMC3):c.42_50dup (p.Pro15_Ala17dup) rs1057520165
NM_006059.4(LAMC3):c.521_522delinsAG (p.Pro174Gln) rs386738954
NM_006059.4(LAMC3):c.522C>G (p.Pro174=) rs2275136
NM_006059.4(LAMC3):c.855A>G (p.Ala285=) rs2275132
NM_006059.4(LAMC3):c.903_904del (p.Cys301_Glu302delinsTer) rs761516738

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