ClinVar Miner

Variants in gene MLH3 with conflicting interpretations

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Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
495 24 0 21 14 0 1 35

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic uncertain significance likely benign benign
pathogenic 0 1 0 0
uncertain significance 1 0 7 8
likely benign 0 7 0 21
benign 0 8 21 0

All variants with conflicting interpretations #

Total variants: 35
Download table as spreadsheet
HGVS dbSNP
NM_001040108.1(MLH3):c.1258G>A (p.Val420Ile) rs28756982
NM_001040108.1(MLH3):c.149T>A (p.Phe50Tyr) rs148409389
NM_001040108.1(MLH3):c.1870G>C (p.Glu624Gln) rs28756986
NM_001040108.1(MLH3):c.1939C>T (p.Arg647Cys) rs28756987
NM_001040108.1(MLH3):c.2159A>G (p.Tyr720Cys) rs28756988
NM_001040108.1(MLH3):c.2167G>A (p.Val723Ile) rs28756989
NM_001040108.1(MLH3):c.2425A>G (p.Met809Val) rs61752722
NM_001040108.1(MLH3):c.2490T>G (p.Phe830Leu) rs114015611
NM_001040108.1(MLH3):c.2533A>G (p.Ser845Gly) rs28756992
NM_001040108.1(MLH3):c.2825C>T (p.Thr942Ile) rs17102999
NM_001040108.1(MLH3):c.2838C>A (p.Ser946=) rs181990057
NM_001040108.1(MLH3):c.2896T>C (p.Ser966Pro) rs17782839
NM_001040108.1(MLH3):c.2911G>A (p.Val971Ile) rs41555714
NM_001040108.1(MLH3):c.2924A>G (p.Asn975Ser) rs141066164
NM_001040108.1(MLH3):c.3020A>G (p.Asn1007Ser) rs776639203
NM_001040108.1(MLH3):c.3217G>A (p.Asp1073Asn) rs28756993
NM_001040108.1(MLH3):c.3312C>T (p.Ser1104=) rs149369905
NM_001040108.1(MLH3):c.3315C>A (p.Asp1105Glu) rs28757008
NM_001040108.1(MLH3):c.3384T>C (p.Thr1128=) rs370951929
NM_001040108.1(MLH3):c.3440A>T (p.Asn1147Ile) rs142124529
NM_001040108.1(MLH3):c.3576C>T (p.Leu1192=) rs376981545
NM_001040108.1(MLH3):c.3746C>T (p.Ser1249Phe) rs139265757
NM_001040108.1(MLH3):c.3784C>T (p.Pro1262Ser) rs372912259
NM_001040108.1(MLH3):c.3826T>C (p.Trp1276Arg) rs121908439
NM_001040108.1(MLH3):c.4032C>T (p.Gly1344=) rs565238806
NM_001040108.1(MLH3):c.408T>C (p.Asp136=) rs61755655
NM_001040108.1(MLH3):c.423C>T (p.Ser141=) rs142179277
NM_001040108.1(MLH3):c.4242+13C>G rs77157930
NM_001040108.1(MLH3):c.429G>A (p.Gly143=) rs138943686
NM_001040108.1(MLH3):c.4351G>A (p.Glu1451Lys) rs28939071
NM_001040108.1(MLH3):c.666G>A (p.Lys222=) rs28756980
NM_001040108.1(MLH3):c.691A>C (p.Lys231Gln) rs28756981
NM_001040108.1(MLH3):c.713A>C (p.Tyr238Ser) rs144707485
NM_001040108.1(MLH3):c.837C>T (p.Cys279=) rs149962294
NM_001040108.1(MLH3):c.8A>G (p.Lys3Arg) rs114829239

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