ClinVar Miner

Variants studied for Wilms tumor

Included ClinVar conditions (13):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor other total
62 4 337 56 13 3 6 479

Gene and significance breakdown #

Total genes and gene combinations: 18
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Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign risk factor other total
WT1 13 1 111 32 6 0 0 162
LOC107982234, WT1 6 0 111 18 3 0 0 137
GPC3 12 2 78 6 3 0 0 101
BRCA2 22 0 33 0 1 0 0 56
CTNNB1 0 0 0 0 0 0 3 3
REST 0 0 0 0 0 3 0 3
H19 2 0 0 0 0 0 0 2
H19, H19-ICR, MRPL23 2 0 0 0 0 0 0 2
LOC106707172, LOC107982234, WT1 2 0 0 0 0 0 0 2
MED12 0 0 1 0 0 0 1 2
POU6F2 2 0 0 0 0 0 0 2
CHEK2 1 0 0 0 0 0 0 1
DIS3L2 0 1 0 0 0 0 0 1
FZD6 0 0 0 0 0 0 1 1
MSH2 0 0 1 0 0 0 0 1
SMAD4 0 0 1 0 0 0 0 1
TET2 0 0 0 0 0 0 1 1
VHL 0 0 1 0 0 0 0 1

Submitter and significance breakdown #

Total submitters: 12
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Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor other total
Invitae 25 3 236 30 3 0 0 297
Illumina Clinical Services Laboratory,Illumina 0 0 56 25 7 0 0 88
Fulgent Genetics,Fulgent Genetics 21 0 34 0 1 0 0 56
Mendelics 2 0 17 1 1 0 0 21
OMIM 15 0 0 0 0 3 0 18
Donald Williams Parsons Laboratory,Baylor College of Medicine 2 1 0 0 0 0 6 9
Clinical Genomics Lab,St. Jude Children's Research Hospital 0 0 4 0 0 0 0 4
Athena Diagnostics Inc 0 0 0 0 3 0 0 3
Division of Genomic Diagnostics,The Children's Hospital of Philadelphia 0 0 0 1 0 0 0 1
Institute of Human Genetics,Cologne University 1 0 0 0 0 0 0 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 0 1
Génétique des Maladies du Développement, Hospices Civils de Lyon 0 0 1 0 0 0 0 1

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