ClinVar Miner

Variants studied for Wilms tumor

Included ClinVar conditions (16):
Minimum submission review status: Collection method:
Minimum conflict level:
Gene type:
ClinVar version:

If a variant has more than one submission, it may be counted in more than one significance column. If this is the case, the total number of variants will be less than the sum of the other cells.

pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
176 29 1350 871 138 3 6 5 2525

Gene and significance breakdown #

Total genes and gene combinations: 22
Download table as spreadsheet
Gene or gene combination pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
GPC3 41 6 427 297 69 0 0 0 832
WT1 42 13 391 336 39 0 0 4 796
LOC107982234, WT1 18 4 444 211 12 0 0 0 673
BRCA2 65 4 70 26 17 0 0 1 183
REST 0 0 8 1 0 3 0 0 12
TRIM28 1 0 6 0 0 0 0 0 7
CTNNB1, LOC126806658 0 0 0 0 0 0 2 0 2
H19, H19-ICR, MRPL23 2 0 0 0 0 0 0 0 2
LOC106707172, LOC107982234, LOC130005479, WT1 2 0 0 0 0 0 0 0 2
LOC130065239, TRIM28 0 0 2 0 0 0 0 0 2
MED12 0 0 1 0 0 0 1 0 2
POU6F2 2 0 0 0 0 0 0 0 2
BRAF 1 0 0 0 0 0 0 0 1
CHEK2 1 0 0 0 0 0 0 0 1
CTNNB1 0 0 0 0 0 0 1 0 1
DCDC1, DNAJC24, ELP4, IMMP1L, PAX6, RCN1, WT1 1 0 0 0 0 0 0 0 1
DIS3L2 0 1 0 0 0 0 0 0 1
FZD6 0 0 0 0 0 0 1 0 1
GPC4 0 0 0 0 1 0 0 0 1
IGF2, INS-IGF2 0 1 0 0 0 0 0 0 1
SMAD4 0 0 1 0 0 0 0 0 1
TET2 0 0 0 0 0 0 1 0 1

Submitter and significance breakdown #

Total submitters: 32
Download table as spreadsheet
Submitter pathogenic likely pathogenic uncertain significance likely benign benign risk factor other not provided total
Invitae 92 15 1142 800 100 0 0 0 2149
Fulgent Genetics, Fulgent Genetics 71 5 117 56 18 0 0 0 267
All of Us Research Program, National Institutes of Health 0 2 139 84 4 0 0 0 229
Illumina Laboratory Services, Illumina 0 0 72 14 25 0 0 0 111
St. Jude Molecular Pathology, St. Jude Children's Research Hospital 3 0 24 0 0 0 0 0 27
Genome-Nilou Lab 0 0 0 0 18 0 0 0 18
OMIM 13 0 0 0 0 3 0 0 16
Mendelics 0 0 12 0 1 0 0 0 13
KCCC/NGS Laboratory, Kuwait Cancer Control Center 0 0 0 3 10 0 0 0 13
Baylor Genetics 4 2 4 0 0 0 0 0 10
Color Diagnostics, LLC DBA Color Health 0 0 0 2 8 0 0 0 10
Donald Williams Parsons Laboratory, Baylor College of Medicine 2 1 0 0 0 0 6 0 9
Athena Diagnostics Inc 0 0 0 0 3 0 0 0 3
GeneReviews 0 0 0 0 0 0 0 3 3
Molecular Genetics and NGS Laboratory, Hospital Fundacion Valle Del Lili 2 1 0 0 0 0 0 0 3
Human Genome Sequencing Center Clinical Lab, Baylor College of Medicine 0 1 1 0 0 0 0 0 2
Centre for Mendelian Genomics, University Medical Centre Ljubljana 0 0 2 0 0 0 0 0 2
Genetics and Molecular Pathology, SA Pathology 1 1 0 0 0 0 0 0 2
Institute of Human Genetics, Clinical Exome/Genome Diagnostics Group, University Hospital Bonn 2 0 0 0 0 0 0 0 2
Genomic Diagnostic Laboratory, Division of Genomic Diagnostics, Children's Hospital of Philadelphia 0 0 0 1 0 0 0 0 1
Institute of Human Genetics, Cologne University 1 0 0 0 0 0 0 0 1
Women's Health and Genetics/Laboratory Corporation of America, LabCorp 1 0 0 0 0 0 0 0 1
Institute for Human Genetics and Genomic Medicine, Uniklinik RWTH Aachen 0 1 0 0 0 0 0 0 1
GenomeConnect, ClinGen 0 0 0 0 0 0 0 1 1
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago 0 0 1 0 0 0 0 0 1
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen 1 0 0 0 0 0 0 0 1
Génétique des Maladies du Développement, Hospices Civils de Lyon 0 0 1 0 0 0 0 0 1
Johns Hopkins Genomics, Johns Hopkins University 1 0 0 0 0 0 0 0 1
Pediatric Oncology, Johns Hopkins University 1 0 0 0 0 0 0 0 1
NPCF Sunshine Lab, H. Lee Moffitt Cancer Center and Research Institute 1 0 0 0 0 0 0 0 1
GenomeConnect - Invitae Patient Insights Network 0 0 0 0 0 0 0 1 1
Laan Lab, Human Genetics Research Group, University of Tartu 0 1 0 0 0 0 0 0 1

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.