Variants with conflicting interpretations, by significance

Y axis minimum submission review status:		Y axis collection method:
X axis minimum submission review status:		X axis collection method:
Minimum conflict level: Report conflict between different conditions
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition	Variants with at least 2 submissions on the same condition and no conflicts	Variants with a synonymous conflict (e.g. benign vs non-pathogenic)	Variants with a confidence conflict (e.g. benign vs likely benign)	Variants with a benign or likely benign vs uncertain conflict	Variants with a category conflict (e.g. benign vs affects)	Variants with a clinically significant conflict (e.g. benign vs pathogenic)	Variants with any conflict
2667316	287973	836	76257	62832	1174	15097	142914

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	affects	association	association not found	confers sensitivity	drug response	established risk allele	likely pathogenic, low penetrance	likely risk allele	pathogenic, low penetrance	protective	risk factor	uncertain risk allele	other
pathogenic	213	24164	7094	519	422	78	13	2	2	81	11	4	17	16	4	130	7	128
likely pathogenic	24164	214	9756	550	286	42	7	2	0	43	12	3	11	9	4	51	8	65
uncertain significance	7094	9756	206	56334	13577	33	20	0	0	55	6	1	25	5	5	103	19	154
likely benign	519	550	56334	66	52140	12	19	0	0	58	2	0	8	0	7	74	7	103
benign	422	286	13577	52140	137	24	40	0	4	73	3	0	11	3	20	115	8	62
affects	78	42	33	12	24	0	3	0	0	0	0	0	0	0	0	4	0	1
association	13	7	20	19	40	3	0	0	1	4	2	0	1	0	1	8	0	2
association not found	2	2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
confers sensitivity	2	0	0	0	4	0	1	0	0	0	0	0	0	0	0	0	0	1
drug response	81	43	55	58	73	0	4	0	0	0	0	0	0	0	1	22	1	23
established risk allele	11	12	6	2	3	0	2	0	0	0	0	0	1	1	0	5	0	1
likely pathogenic, low penetrance	4	3	1	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0
likely risk allele	17	11	25	8	11	0	1	0	0	0	1	0	0	0	0	5	0	0
pathogenic, low penetrance	16	9	5	0	3	0	0	0	0	0	1	1	0	0	0	2	0	0
protective	4	4	5	7	20	0	1	0	0	1	0	0	0	0	0	2	1	1
risk factor	130	51	103	74	115	4	8	0	0	22	5	0	5	2	2	0	1	3
uncertain risk allele	7	8	19	7	8	0	0	0	0	1	0	0	0	0	1	1	0	0
other	128	65	154	103	62	1	2	0	1	23	1	0	0	0	1	3	0	0

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