Variants with conflicting interpretations, by significance

Y axis minimum submission review status:		Y axis collection method:
X axis minimum submission review status:		X axis collection method:
Minimum conflict level: Report conflict between different conditions
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition	Variants with at least 2 submissions on the same condition and no conflicts	Variants with a synonymous conflict (e.g. benign vs non-pathogenic)	Variants with a confidence conflict (e.g. benign vs likely benign)	Variants with a benign or likely benign vs uncertain conflict	Variants with a category conflict (e.g. benign vs affects)	Variants with a clinically significant conflict (e.g. benign vs pathogenic)	Variants with any conflict
2990320	305367	866	82263	67889	1188	16451	154499

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	affects	association	association not found	confers sensitivity	drug response	established risk allele	likely pathogenic, low penetrance	likely risk allele	pathogenic, low penetrance	protective	risk factor	uncertain risk allele	other
pathogenic	215	27130	7622	535	416	79	13	3	2	81	11	4	18	17	4	121	7	129
likely pathogenic	27130	233	10870	577	304	42	7	1	0	41	13	3	12	11	3	54	8	67
uncertain significance	7622	10870	210	60770	14680	33	20	0	0	56	7	1	27	5	5	102	19	175
likely benign	535	577	60770	67	55186	12	19	0	0	58	2	0	8	0	7	72	7	104
benign	416	304	14680	55186	141	25	40	0	4	74	3	0	12	3	20	110	8	63
affects	79	42	33	12	25	0	3	0	0	0	0	0	0	0	0	2	0	1
association	13	7	20	19	40	3	0	0	1	4	2	0	2	0	1	6	0	2
association not found	3	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
confers sensitivity	2	0	0	0	4	0	1	0	0	0	0	0	0	0	0	0	0	1
drug response	81	41	56	58	74	0	4	0	0	0	0	0	0	0	0	21	1	23
established risk allele	11	13	7	2	3	0	2	0	0	0	0	0	1	1	0	5	0	1
likely pathogenic, low penetrance	4	3	1	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0
likely risk allele	18	12	27	8	12	0	2	0	0	0	1	0	0	0	0	5	0	0
pathogenic, low penetrance	17	11	5	0	3	0	0	0	0	0	1	1	0	0	0	2	0	0
protective	4	3	5	7	20	0	1	0	0	0	0	0	0	0	0	2	1	1
risk factor	121	54	102	72	110	2	6	0	0	21	5	0	5	2	2	0	1	3
uncertain risk allele	7	8	19	7	8	0	0	0	0	1	0	0	0	0	1	1	0	0
other	129	67	175	104	63	1	2	0	1	23	1	0	0	0	1	3	0	0

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.