ClinVar Miner

Variants with conflicting interpretations, by significance

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
376208 84160 2178 28336 20066 978 5946 50889

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign affects association drug response protective risk factor other
pathogenic 1477 8061 3038 563 358 24 14 109 16 188 211
likely pathogenic 8061 151 3237 291 152 2 7 54 1 82 45
uncertain significance 3038 3237 292 17578 6676 8 10 49 3 95 79
likely benign 563 291 17578 58 20299 7 13 21 13 89 54
benign 358 152 6676 20299 206 10 22 39 15 109 55
affects 24 2 8 7 10 0 5 4 0 5 4
association 14 7 10 13 22 5 0 3 2 8 6
drug response 109 54 49 21 39 4 3 0 2 31 24
protective 16 1 3 13 15 0 2 2 0 10 2
risk factor 188 82 95 89 109 5 8 31 10 0 6
other 211 45 79 54 55 4 6 24 2 6 0

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