ClinVar Miner

Variants with conflicting interpretations, by significance

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
2495693 190353 814 68716 55102 1124 13585 127067

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign affects association association not found confers sensitivity drug response established risk allele likely risk allele pathogenic, low penetrance protective risk factor uncertain risk allele other
pathogenic 212 21728 6577 500 431 76 12 2 2 81 11 17 16 4 127 3 124
likely pathogenic 21728 207 8531 504 266 36 7 2 0 41 10 10 8 4 46 5 57
uncertain significance 6577 8531 197 49216 12357 30 18 0 0 50 6 23 6 5 98 17 148
likely benign 500 504 49216 63 47035 11 17 0 0 62 2 6 0 7 70 7 102
benign 431 266 12357 47035 135 23 40 0 3 74 3 9 2 17 122 7 61
affects 76 36 30 11 23 0 3 0 0 0 0 0 0 0 4 0 1
association 12 7 18 17 40 3 0 0 1 4 2 1 0 1 8 0 2
association not found 2 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
confers sensitivity 2 0 0 0 3 0 1 0 0 0 0 0 0 0 0 0 1
drug response 81 41 50 62 74 0 4 0 0 0 0 0 0 1 24 1 24
established risk allele 11 10 6 2 3 0 2 0 0 0 0 1 1 0 5 0 1
likely risk allele 17 10 23 6 9 0 1 0 0 0 1 0 0 0 5 0 0
pathogenic, low penetrance 16 8 6 0 2 0 0 0 0 0 1 0 0 0 2 0 0
protective 4 4 5 7 17 0 1 0 0 1 0 0 0 0 2 1 1
risk factor 127 46 98 70 122 4 8 0 0 24 5 5 2 2 0 1 3
uncertain risk allele 3 5 17 7 7 0 0 0 0 1 0 0 0 1 1 0 0
other 124 57 148 102 61 1 2 0 1 24 1 0 0 1 3 0 0

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