ClinVar Miner

Variants with conflicting interpretations, by significance

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission Variants with at least 2 submissions and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any kind of conflict
590298 117104 2292 40436 37156 1158 8902 78292

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign affects association drug response protective risk factor other
pathogenic 1508 11340 4620 755 670 50 19 118 17 207 226
likely pathogenic 11340 181 4891 484 324 20 7 61 3 91 59
uncertain significance 4620 4891 334 31486 13755 16 10 53 5 111 124
likely benign 755 484 31486 59 29148 3 13 44 13 97 86
benign 670 324 13755 29148 217 15 28 66 19 148 70
affects 50 20 16 3 15 0 5 4 0 6 4
association 19 7 10 13 28 5 0 4 3 8 6
drug response 118 61 53 44 66 4 4 0 3 36 29
protective 17 3 5 13 19 0 3 3 0 10 2
risk factor 207 91 111 97 148 6 8 36 10 0 9
other 226 59 124 86 70 4 6 29 2 9 0

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