Variants with conflicting interpretations, by significance

Y axis minimum submission review status:		Y axis collection method:
X axis minimum submission review status:		X axis collection method:
Minimum conflict level: Report conflict between different conditions
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition	Variants with at least 2 submissions on the same condition and no conflicts	Variants with a synonymous conflict (e.g. benign vs non-pathogenic)	Variants with a confidence conflict (e.g. benign vs likely benign)	Variants with a benign or likely benign vs uncertain conflict	Variants with a category conflict (e.g. benign vs affects)	Variants with a clinically significant conflict (e.g. benign vs pathogenic)	Variants with any conflict
3110616	314309	873	85308	70188	1200	16907	159875

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	affects	association	association not found	confers sensitivity	drug response	established risk allele	likely pathogenic, low penetrance	likely risk allele	pathogenic, low penetrance	protective	risk factor	uncertain risk allele	other
pathogenic	217	28177	7686	540	423	53	12	3	2	81	11	4	20	17	4	123	7	131
likely pathogenic	28177	236	11356	594	311	30	7	1	0	44	13	3	20	12	3	61	11	71
uncertain significance	7686	11356	211	62969	14982	31	24	0	1	58	7	2	32	5	5	108	22	180
likely benign	540	594	62969	67	57189	12	19	0	0	59	2	0	8	0	7	72	8	110
benign	423	311	14982	57189	142	25	40	0	4	80	3	0	14	3	20	109	8	63
affects	53	30	31	12	25	0	3	0	0	0	0	0	0	0	0	2	0	1
association	12	7	24	19	40	3	0	0	1	4	2	0	2	0	1	6	0	3
association not found	3	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
confers sensitivity	2	0	1	0	4	0	1	0	0	0	0	0	0	0	0	0	0	1
drug response	81	44	58	59	80	0	4	0	0	0	0	0	0	0	0	21	1	23
established risk allele	11	13	7	2	3	0	2	0	0	0	0	0	4	1	0	5	0	1
likely pathogenic, low penetrance	4	3	2	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0
likely risk allele	20	20	32	8	14	0	2	0	0	0	4	0	0	0	0	5	0	0
pathogenic, low penetrance	17	12	5	0	3	0	0	0	0	0	1	1	0	0	0	2	0	0
protective	4	3	5	7	20	0	1	0	0	0	0	0	0	0	0	2	1	1
risk factor	123	61	108	72	109	2	6	0	0	21	5	0	5	2	2	0	1	3
uncertain risk allele	7	11	22	8	8	0	0	0	0	1	0	0	0	0	1	1	0	0
other	131	71	180	110	63	1	3	0	1	23	1	0	0	0	1	3	0	0

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