Variants with conflicting interpretations, by significance

Y axis minimum submission review status:		Y axis collection method:
X axis minimum submission review status:		X axis collection method:
Minimum conflict level: Report conflict between different conditions
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition	Variants with at least 2 submissions on the same condition and no conflicts	Variants with a synonymous conflict (e.g. benign vs non-pathogenic)	Variants with a confidence conflict (e.g. benign vs likely benign)	Variants with a benign or likely benign vs uncertain conflict	Variants with a category conflict (e.g. benign vs affects)	Variants with a clinically significant conflict (e.g. benign vs pathogenic)	Variants with any conflict
2637756	206332	827	71318	59478	1142	14320	134310

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	affects	association	association not found	confers sensitivity	drug response	established risk allele	likely risk allele	pathogenic, low penetrance	protective	risk factor	uncertain risk allele	other
pathogenic	214	22894	6876	500	419	77	13	2	2	80	11	17	16	4	127	7	127
likely pathogenic	22894	212	9120	521	264	36	7	2	0	42	11	10	9	4	47	8	60
uncertain significance	6876	9120	203	53204	13096	31	19	0	0	54	6	25	6	5	102	19	146
likely benign	500	521	53204	63	48470	12	18	0	0	61	2	6	0	7	73	7	103
benign	419	264	13096	48470	135	23	39	0	3	71	4	9	3	17	119	7	61
affects	77	36	31	12	23	0	3	0	0	0	0	0	0	0	4	0	1
association	13	7	19	18	39	3	0	0	1	4	2	1	0	1	8	0	2
association not found	2	2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
confers sensitivity	2	0	0	0	3	0	1	0	0	0	0	0	0	0	0	0	1
drug response	80	42	54	61	71	0	4	0	0	0	0	0	0	1	22	1	23
established risk allele	11	11	6	2	4	0	2	0	0	0	0	1	1	0	5	0	1
likely risk allele	17	10	25	6	9	0	1	0	0	0	1	0	0	0	5	0	0
pathogenic, low penetrance	16	9	6	0	3	0	0	0	0	0	1	0	0	0	2	0	0
protective	4	4	5	7	17	0	1	0	0	1	0	0	0	0	2	1	1
risk factor	127	47	102	73	119	4	8	0	0	22	5	5	2	2	0	1	3
uncertain risk allele	7	8	19	7	7	0	0	0	0	1	0	0	0	1	1	0	0
other	127	60	146	103	61	1	2	0	1	23	1	0	0	1	3	0	0

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