ClinVar Miner

Variants with conflicting interpretations, by significance

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
735767 62817 1683 23487 18768 693 5061 44689

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign affects association drug response protective risk factor other
pathogenic 1196 6961 2603 380 313 27 10 71 5 96 92
likely pathogenic 6961 142 2466 218 126 8 2 22 3 25 26
uncertain significance 2603 2466 161 15467 5948 7 3 23 5 64 82
likely benign 380 218 15467 44 16548 2 7 30 6 50 64
benign 313 126 5948 16548 143 8 17 53 11 82 39
affects 27 8 7 2 8 0 3 0 0 4 2
association 10 2 3 7 17 3 0 3 1 7 1
drug response 71 22 23 30 53 0 3 0 2 13 23
protective 5 3 5 6 11 0 1 2 0 3 0
risk factor 96 25 64 50 82 4 7 13 3 0 6
other 92 26 82 64 39 2 1 23 0 6 0

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