ClinVar Miner

Variants with conflicting interpretations, by significance

Y axis minimum submission review status: Y axis collection method:
X axis minimum submission review status: X axis collection method:
Minimum conflict level:
ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition Variants with at least 2 submissions on the same condition and no conflicts Variants with a synonymous conflict
(e.g. benign vs non-pathogenic)
Variants with a confidence conflict
(e.g. benign vs likely benign)
Variants with a benign or likely benign vs uncertain conflict Variants with a category conflict
(e.g. benign vs affects)
Variants with a clinically significant conflict
(e.g. benign vs pathogenic)
Variants with any conflict
808850 68795 1723 25643 20894 741 6009 49315

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

pathogenic likely pathogenic uncertain significance likely benign benign affects association confers sensitivity drug response protective risk factor other
pathogenic 1222 8106 3180 419 364 28 17 2 72 5 105 100
likely pathogenic 8106 146 2959 238 138 9 5 0 22 2 25 30
uncertain significance 3180 2959 170 17356 6484 8 5 0 29 5 71 104
likely benign 419 238 17356 45 17563 3 8 0 30 6 49 70
benign 364 138 6484 17563 144 8 18 2 54 12 83 44
affects 28 9 8 3 8 0 3 0 0 0 5 2
association 17 5 5 8 18 3 0 1 3 1 9 1
confers sensitivity 2 0 0 0 2 0 1 0 0 0 0 0
drug response 72 22 29 30 54 0 3 0 0 2 14 24
protective 5 2 5 6 12 0 1 0 2 0 3 1
risk factor 105 25 71 49 83 5 9 0 14 3 0 7
other 100 30 104 70 44 2 1 0 24 1 7 0

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