Variants with conflicting interpretations, by significance

Y axis minimum submission review status:		Y axis collection method:
X axis minimum submission review status:		X axis collection method:
Minimum conflict level: Report conflict between different conditions
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition	Variants with at least 2 submissions on the same condition and no conflicts	Variants with a synonymous conflict (e.g. benign vs non-pathogenic)	Variants with a confidence conflict (e.g. benign vs likely benign)	Variants with a benign or likely benign vs uncertain conflict	Variants with a category conflict (e.g. benign vs affects)	Variants with a clinically significant conflict (e.g. benign vs pathogenic)	Variants with any conflict
3114294	315312	13	87038	70459	1195	17016	161474

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	affects	association	association not found	confers sensitivity	drug response	established risk allele	likely pathogenic, low penetrance	likely risk allele	pathogenic, low penetrance	protective	risk factor	uncertain risk allele	other
pathogenic	0	28295	7722	543	421	53	12	3	2	81	11	4	20	17	4	119	7	132
likely pathogenic	28295	1	11448	600	311	30	7	1	0	44	13	3	20	12	3	61	11	71
uncertain significance	7722	11448	11	63231	15085	31	24	0	1	58	7	2	32	5	5	107	22	181
likely benign	543	600	63231	1	58802	12	18	0	0	59	2	0	8	0	7	72	9	110
benign	421	311	15085	58802	0	25	38	0	4	80	3	0	14	3	20	105	9	62
affects	53	30	31	12	25	0	3	0	0	0	0	0	0	0	0	2	0	1
association	12	7	24	18	38	3	0	0	1	4	2	0	2	0	1	4	0	3
association not found	3	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
confers sensitivity	2	0	1	0	4	0	1	0	0	0	0	0	0	0	0	0	0	1
drug response	81	44	58	59	80	0	4	0	0	0	0	0	0	0	0	21	1	23
established risk allele	11	13	7	2	3	0	2	0	0	0	0	0	4	2	0	5	0	1
likely pathogenic, low penetrance	4	3	2	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0
likely risk allele	20	20	32	8	14	0	2	0	0	0	4	0	0	0	0	5	0	0
pathogenic, low penetrance	17	12	5	0	3	0	0	0	0	0	2	1	0	0	0	2	0	0
protective	4	3	5	7	20	0	1	0	0	0	0	0	0	0	0	2	1	1
risk factor	119	61	107	72	105	2	4	0	0	21	5	0	5	2	2	0	1	3
uncertain risk allele	7	11	22	9	9	0	0	0	0	1	0	0	0	0	1	1	0	0
other	132	71	181	110	62	1	3	0	1	23	1	0	0	0	1	3	0	0

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