Variants with conflicting interpretations, by significance

Y axis minimum submission review status:		Y axis collection method:
X axis minimum submission review status:		X axis collection method:
Minimum conflict level: Report conflict between different conditions
Show significances as they were submitted (without aggregation into standard terms)
		ClinVar version:

If a variant has more than two submissions, it may have multiple conflicts and therefore be counted in more than one conflict column. If this is the case, the "Variants with any kind of conflict" cell will be less than the sum of the conflicted variants cells to its left.

Variants with only 1 submission per condition	Variants with at least 2 submissions on the same condition and no conflicts	Variants with a synonymous conflict (e.g. benign vs non-pathogenic)	Variants with a confidence conflict (e.g. benign vs likely benign)	Variants with a benign or likely benign vs uncertain conflict	Variants with a category conflict (e.g. benign vs affects)	Variants with a clinically significant conflict (e.g. benign vs pathogenic)	Variants with any conflict
2852814	299921	865	80876	66010	1160	16045	150979

Significance breakdown #

In the table below, cells that correspond to a term paired with itself represent synonymous conflicts, i.e. variants that have been annotated with different terms that map to the same standard term. To compare the terms that were actually submitted, check the box in the filters section at the top of this page.

	pathogenic	likely pathogenic	uncertain significance	likely benign	benign	affects	association	association not found	confers sensitivity	drug response	established risk allele	likely pathogenic, low penetrance	likely risk allele	pathogenic, low penetrance	protective	risk factor	uncertain risk allele	other
pathogenic	214	26336	7326	528	420	52	13	2	2	81	11	4	18	16	4	129	7	128
likely pathogenic	26336	233	10682	567	299	29	7	2	0	41	13	3	12	10	4	53	8	66
uncertain significance	7326	10682	210	59279	14118	27	20	0	0	56	6	1	27	5	5	104	19	173
likely benign	528	567	59279	67	54591	12	19	0	0	56	2	0	8	0	7	72	7	103
benign	420	299	14118	54591	141	24	40	0	4	72	3	0	12	3	20	111	8	62
affects	52	29	27	12	24	0	3	0	0	0	0	0	0	0	0	2	0	1
association	13	7	20	19	40	3	0	0	1	4	2	0	2	0	1	6	0	2
association not found	2	2	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
confers sensitivity	2	0	0	0	4	0	1	0	0	0	0	0	0	0	0	0	0	1
drug response	81	41	56	56	72	0	4	0	0	0	0	0	0	0	1	21	1	23
established risk allele	11	13	6	2	3	0	2	0	0	0	0	0	1	1	0	5	0	1
likely pathogenic, low penetrance	4	3	1	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0
likely risk allele	18	12	27	8	12	0	2	0	0	0	1	0	0	0	0	5	0	0
pathogenic, low penetrance	16	10	5	0	3	0	0	0	0	0	1	1	0	0	0	2	0	0
protective	4	4	5	7	20	0	1	0	0	1	0	0	0	0	0	2	1	1
risk factor	129	53	104	72	111	2	6	0	0	21	5	0	5	2	2	0	1	3
uncertain risk allele	7	8	19	7	8	0	0	0	0	1	0	0	0	0	1	1	0	0
other	128	66	173	103	62	1	2	0	1	23	1	0	0	0	1	3	0	0

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